个人简介
1979-1983年 南开大学化学系本科
1983-1986年 南开大学高分子所硕士研究生
1986-1989年 南开大学高分子所博士研究生
1989-1992年 南开大学高分子所任讲师;
1992 年 晋升为副教授;
1996 年 晋升为教授;
2000-2004年 南开大学高分子所所长;
2000-2013年 南开大学化学学院副院长;
2013至2018 南开大学学位评定委员会高分子分委会主席;化学学院学术委员会委员
荣誉和奖励
入选教育部跨世纪优秀青年培养计划
天津市“131工程”第一层次
获中国化学会青年化学奖、天津市第三届青年科技奖、天津市科技进步二等奖,教育部科技进步三等奖、科技部杜邦科技创新奖、国家科技进步二等奖(2009),获全国先进女职工称号。
研究领域
1、吸附分离功能高分子材料研究
2、医用高分子材料研究
近期论文
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Zhi Yuan*, Convenient preparation of charge-adaptive chitosan nanomedicines for extended blood circulation and accelerated endosomal escape, Nano Research, 2018,11,8:4278-4292
Zhi Yuan**, A Conveniently Self-assembed Pt (IV) Conjugated Nanocarrier by the Character of Glycyrrhetinic Acid for Targeting Treatment of Hepatic Carcinoma, Nanomedicine: NBM,2018, Accepted
Zhi Yuan*,The Systematic Evaluation of Size-dependent Toxicity and Multi-time Biodistribution of Gold Nanoparticles,Colloids and Surfaces B: Biointerfaces. 2018, 167:260-266
Zhi Yuan*, The effects of ligand valency and density on the targeting ability of multivalent nanoparticles based on negatively charged chitosan nanoparticles, Colloids and Surfaces B: Biointerfaces, 2018, 161:508-518
Zhi Yuan*, pH-Sensitive Reversible Programmed Targeting Strategy by the Self-Assembly/Disassembly of Gold Nanoparticles, ACS Applied Materials & Interfaces, 2017,9:16767-16777
Zhi Yuan*, An Intelligent Re-Shieldable Targeting System for Enhanced Tumor Accumulation, Journal of Controlled Release, 2017,268:1–9
hi Yuan*,Facile fabrication of poly(acrylic acid) coated chitosan nanoparticles with improved stability in biological environments,European Journal of Pharmaceutics and Biopharmaceutics,2017,112:148-1544
Zhi Yuan*, The Study of a Bifunctional Aβ Aggregation Inhibitor with the Abilities of Anti-amyloid and Copper Chelation,Biomacromolecules,2016, 17 (2):661–668
Zhi Yuan*, A tripeptide GGH as the inhibitor of copper-amyloid-β-mediated redox reaction and toxicity, ACS Chemical Neuroscience, 2016, 7 (9):1255–1263
Zhi Yuan*, In Vitro Studies on Accelerating the Degradation and Clear-ance of Amyloid-β Fibrils by an Anti-amyloidogenic Peptide, ACS Macromolecules Letter, 2015, 4(3): 339-342
Zhi Yuan*, Shieldable Tumor Targeting Based on pH Responsive Self-Assembly/Disassembly of Gold Nanoparticles, ACS Applied Materials & Interfaces , 2014, 6(20), 17865–17876
Zhi Yuan*, Study on the efficiency and interaction mechanism of a decapeptide inhibitor of β-amyloid aggregation, Biomacromolecules. 2014, 15(3):931-939
Zhi Yuan*, Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy, Biomaterials, 2012, 33(7): 2187–2196
Zhi Yuan*, A New Method for Affinity Adsorbent Screening Using Gold Colloids, Langmuir, 2011, 27(18):11457–11465
Zhi Yuan*, Novel Silk Fibroin/Montmorillonite Nanocomposites: Effect of pH on the Conformational Transition and Clay Dispersion, Biomacromolecules, 2010, 11(7):1796–1801
Zhi Yuan*, Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(γ-benzyl L-glutamate) micelles for liver targeting therapy, Acta Biomaterialia, 2010, 6(10):3927-3935
Zhi Yuan*, Glycyrrhetinic acid-modified chitosan / poly(ethylene glycol) nanoparticles for liver-targeted delivery, Biomaterials, 2010, 31(17):4748-56
Zhi Yuan*, Adsorption mechanism at molecular level between polymers and uremic octapeptide by 2D 1H NMR technique,Biomacromolecules,2006, 7(6):1811-1818
Zhi Yuan* ,Endotoxin adsorbent using dimethylamine ligands, Biomaterials, 2005,26(15):2741-2747