VanNieuwenhze, Michael - Indiana University

个人简介

Michael VanNieuwenhze received is B.A. degree from Kalamazoo College in 1984 and his M.S. from Yale University in 1988. After obtaining his Ph.D. from Indiana University in 1992 while working in the laboratories of Professor William Roush, he moved to The Scripps Research Institute in La Jolla, California where he was an NIH Postdoctoral Fellow while working in the laboratories of Professor K. Barry Sharpless. In 1994, Professor VanNieuwenhze accepted a position in Discovery Chemistry Research at Eli Lilly and Company in Indianapolis. In 2002, he accepted a faculty position at the University of California, San Diego and in 2007, he returned to Indiana University as an Associate Professor in the Department of Chemistry.

研究领域

synthesis, study, and design of antibiotics that inhibit bacterial cell wall biosynthesis; peptidoglycan biosynthesis and bacterial cell morphology; development of HBV capsid-binding probes and assembly-directed antivirals; oxidized phospholipids in disease and diagnostics

近期论文

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Kuru, E.; Tekkam, S.; Hall, E.; Brun, Y. V.*; VanNieuwenhze, M. S.,"Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ," Nat. Protoc. 2015, 10, 33-52. DOI: 10.1038/nprot.2014.197. van Teeseling, M. C. F.; Mesman, R. J.; Kuru, E.; Espaillat, A.; Cava, F.; Brun, Y. V.; VanNieuwenhze, M. S.; Kartal, B.; van Niftrik, L., "Breaking a Dogma by Identifying Peptidoglycan in an Annamox Planctomycete," manuscript submitted to Nature Communications. Pasciak, E. M.; Rittichier, J. R.; Chen, C.-H.; Mubarak, M.; VanNieuwenhze, M. S.; Peters, D. G., Electroreductive Dimerization of Coumarin and Coumarin Analogues at Carbon Cathodes," J. Org. Chem. 2014, DOI: 10.1021/jo502272g (published online November 26, 2014). Fleurie, A.; Lesterlin, C.; Zhao, C.; Manuse, S.; Cluzel, C.; Campo, N.; Lavergne, J.-P.; Franz, M.; Macek, B.; Kuru, E.; VanNieuwenhze, M. S.; Brun, Y.; Sherratt, D.; Gangreasse, C., "Finding midcell: MapZ beacons the division sites and positions FtsZ-rings in streptococci," Nature 2014, 516, 259-262.DOI: 10.1038/nature13966. Gonen, A.; Hansen, L. F.; Turner, W. W.; Montano, E. N.; Que, X.; Rafia, A.; Chou, M.-Y.; Wiesner, P.; Tsiantoulas, D.; Corr, M.; VanNieuwenhze, M. S.; Tsimikas, S.; Binder, C. J.; Witztum, J. L.; Hartvigsen, K., Atheroprotective immunization with malondialdehyde modified LDL is hapten specific, dependent on advanced MDA-adducts: Implicatons for development of an atheroprotective vaccine," J. Lipid Res., 2014, DOI: 10.1194/jlr.M053256. Fleurie, A.; Manuse, S; Zhao, C.; Campo, N.; Cluzel, C.; Lavergne, J.-P.; Freton, C.; Guiral, S.; Soufi, B.; Macek, B.; Kuru, E.; VanNieuwenhze, M. S., Brun, Y.; DiGuilmi, A.-M.; Claverys, J.-P.; Galinier, A.; Grangeasse, C., "Interplay of the serine/threonine kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division," manuscript accepted by PLOS Genetics 2014, DOI: 10.1371/journal.pgen.1004275. Liechti, G.; Kuru, E.; Hall, E.; Kalinda, A.; Brun, Y. V.; VanNieuwenhze, M. S.*; Maurelli, A*. T., "A new metabolic cell wall labeling method reveals peptidoglycan in Chlamydia trachomatis," Nature 2013, 506, 507-510. Indiana University News Release: "IU-designed probe opens new path for drug development against leading STD," December 11, 2013. Research Highlight: "Chlamydiae play by their own rules," Nat. Rev. Microbiol., published online December 23, 2013, DOI:10.1038/nrmicro3198. Highlighted in, "Revealing Bacterial Building Blocks," Inside Life Science, published online by the National Institute of General Medical Sciences, December 24, 2013. (http://publications.nigms.nih.gov/insidelifescience/holiday-season-cells.html) Highlighted in, "IU Researchers Solve Chlamydia Bacteria Mystery," posted December 26, 2013. (http://indianapublicmedia.org/news/iu-researchers-solve-chlamydia-bacteria-mystery-60561/) Highlighted by Faculty of 1000 Prime, January 27, 2014. Pilhofer, M.; Aistleitner, K.; Biboy, J.; Gray, J.; Kuru, E.; Hall, E.; Brun, Y. V.; VanNieuwenhze, M. S.; Vollmer, W.; Horn, M.; Jensen, G., "Chlamydial peptidoglycan: bacteria with a murein sacculus but without FtsZ," Nat. Commun. 2013, 4, 2856. Tocheva, E. I.; López-Garrido, Hughes, V.; Fredlund, J.; Kuru, E.; VanNieuwenhze, M. S.; Brun, Y.; Pogliano, K.; Jensen, G. J., "Peptidoglycan transformations during Bacillus subtilis sporulation," Mol. Microbiol. 2013, 88(9), 673-686. Kim, S. J.; Singh, M.; Wohlrab, A.; Yu, T.-Y.; O’Connor, R. D.; VanNieuwenhze, M. S.*; Schaefer, J.*, "Isotridecanyl Side Chain of Plusbacin A3 is Essential for the Transglycosylase Inhibition of Peptidoglycan Biosynthesis," Biochemistry 2013, 52, 1973-1979. VIEW FIGURE article link Kuru, E.; Hughes, H. V.; Brown, P. J. B.; Hall, E.; Tekkam, S.; dePedro, M. A.; Brun, Y. V.*; VanNieuwenhze, M. S.*, "Direct Fluorescent Labeling of Newly Synthesized Peptidoglycan in Live Bacterial Cells," Angew. Chem. Int. Ed. 2012, 51, 12519-12523. Designated a ‘hot paper’ by the editors of Angewandte Chemie Inside cover highlight, Angew. Chem. Int. Ed. 2012, 51, 12378. Indiana University News Release "Filming bacterial life in multicolor as a new diagnostic and antibiotic discovery tool," October 11, 2012. Highlighted in Chem. Eng. News 2012, 90 (43), 35. Research Highlight in Nat. Rev. Microbiol. 2012, 12, 802. Highlighted in NIGMS Biomedical Beat, November 15, 2012. "Bacterial Portrait Sessions," on the PBS series, "A Moment of Science," broadcast March 25, 2013. o Sightings feature: "See How They Grow,"appeared in American Scientist, April, 2013. VIEW FIGURE article link Kuru, E.; Hughes, H. V.; Brown, P. J. B.; Hall, E.; Tekkam, S.; Cava, F.; de Pedro, M. A.; Brun, Y. V.*; VanNieuwenhze, M. S.*, "Direct Fluorescent Labeling of Newly Synthesized Peptidoglycan in Live Bacterial Cells," Angew. Chem. 2012, 124, 12687-12691. Designated a ‘hot paper’ by the editors of Angewandte Chemie Inside cover highlight, Angewandte Chemie 2012, 124, 12546. Garcia-Reynaga, P.; VanNieuwenhze, M. S.*, "Biomimetic Synthesis of Cbz-(S)-Dolaphenine," Tetrahedron Lett. 2012, 53, 4889-4893. VIEW FIGURE article link Turner, W. W.; Hartvigsen, K.; Boullier, A.; Montano, E. N.; Witztum, J.; VanNieuwenhze, M. S.* "Design and Synthesis of a Stable Oxidized Phospholipid Mimic with Specific Binding Recognition for Macrophage Scavenger Receptors," J. Med. Chem. 2012, 55, 8178-8182. VIEW FIGURE article link Hall, E. A.; Kuru, E.; VanNieuwenhze, M. S.* "Solid-Phase Synthesis of Lysobactin (Katanosin B): Insights into Structure and Function," Org. Lett. 2012, 14, 2730-2733. VIEW FIGURE article link Peng, R.; VanNieuwenhze, M. S.* "A Model Study for Construction of the DEF-Benzoxocin Ring System of Nogalamycin via Reductive Heck Cyclization," Org. Lett. 2012, 14, 1962-1965. VIEW FIGURE article link Carrillo, A. K.; VanNieuwenhze, M. S.* "Synthesis of the AviMeCys-Containing D-Ring of Mersacidin," Org. Lett. 2012, 14, 1034-1037. Manuscript selected for inclusion in a 2012 JACS Select Issue on Peptide Chemistry that highlights noteworthy research in peptide chemistry from Organic Letters, The Journal of Organic Chemistry, and The Journal of the American Chemical Society VIEW FIGURE article link Garcia-Reynaga, P.; Carrillo, A. K.; VanNieuwenhze, M. S.* "Decarbonylative Approach to the Synthesis of Enamides from Amino Acids: Stereoselective Synthesis of the (S)-(Z)-Aminovinyl–D-Cysteine Unit of Mersacidin," Org. Lett. 2012, 14, 1030-1033. VIEW FIGURE article link Olivier, K. S.; VanNieuwenhze, M. S.* "Synthetic Studies toward the Mannopeptimycins: Synthesis of Orthogonally Protected b-Hydroxyenduracididines," Org. Lett. 2010, 12, 1680-1683. Zemski Berry, K. A.; Turner, W. W.; VanNieuwenhze, M. S.; Murphy, R. C., "Characterization of Oxidized Phosphatidylethanolamine Derived from RAW 264.7 Cells using 4-(Dimethylamino)benzoic Acid Derivatives," Eur. J. Mass Spectrom. 2010, 16, 463-470. Zemski Berry, K. A.; Turner, W. W.; VanNieuwenhze, M. S.; Murphy, R. C. "Stable Isotope Labeled 4-(Dimethylamino)benzoic Acid Derivatives of Glycerophosphoethanolamine Lipids" Anal. Chem. 2009, 81, 6633-6640.