个人简介
Education
1998-2001 Department of Chemistry, Nankai University, China. Received PhD degree in June, 2001 (with Prof. Yun-Ti Chen)
1995-1998 Department of Chemistry, Nankai University, China. Received MS degree in June, 2001 (with Prof. Huakuan Lin)
1991-1995 Department of Chemistry, Qufu Normal University, Qufu, China. Received BSc Degree in June, 1991
Academic Career
2010- Professor, Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin, China
2004-2010 Postdoctoral associate and then Research Fellow, Research School of Chemistry, Australian National University, Australia (with Prof. Gottfried Otting)
2001-2004 Postdoctoral associate, Magnetic Resonance Center (CERM), University of Florence, Italy (with Prof. Ivano Bertini)
研究领域
Protein chemistry: methods in protein modifications, protein coupling reactions and biosynthesis
Methods of biological magnetic resonance for the in-cell applications
Chemical biology and biochemical analysis
近期论文
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Su XC*, Zhang LY, Zhao LN, Pan BB, Chen BG, Chen JL, Zhai CL, Li B. Efficient protein-protein couplings mediated by small molecules under mild conditions. Angew. Chem. Int. Ed. Engl. 2022 doi: 10.1002/anie.202205597.
Chen YT, Li B, Chen JL, Su XC*. Simultaneous discrimination and quantification of enantiomeric amino acids under physiological conditions by chiral 19F NMR tag. Anal. Chem. 2022, 94, 7853-7860.
Wu X, Ma F*, Pan BB, Zhang Y, Zhu L, Deng F, Xu L, Zhao Y, Yin X, Niu H, Su XC*, Shi L*. Tailoring a nanochaperone to regulate α-synuclein assembly. Angew. Chem. Int. Ed. Engl. 2022 doi: 10.1002/anie.202200192.
Cui CY, Li B, Cheng D, Li XY, Chen JL, Chen YT, Su XC*. Simultaneous quantification of biothiols and deciphering diverse GSH stability in different live cells by 19F-tag. Anal. Chem. 2022, 94, 901-908.
Chen YT, Li B, Li XY, Chen JL, Cui CY, Hu K, Su XC*. Simultaneous identification and quantification of amino acids in biofluids by reactive 19F-tags. Chem. Commun. 2021, 13154-13157.
Ma B, Chen JL, Cui CY, Yang F, Gong YJ, Su XC.* Rigid, highly reactive and stable DOTA-like tags containing a thiol-specific phenylsulfonyl pyridine moiety for protein modification and NMR analysis. Chem. Eur. J. 2021, 17, 16145-16152.
Chen JL, Chen BG, Li B, Yang F, Su XC*. Assessing multiple conformations of lanthanide binding tags for proteins using a sensitive 19F‐reporter. Chem. Commun. 2021, 4291‐4294.
Chen JL, Li B, Li XY, Su XC*. Dynamic exchange of the metal chelating moiety: a key factor in determining the rigidity of protein‐tag conjugates in paramagnetic NMR. J. Phys. Chem. Lett. 2020, 11, 9493‐9500.
Yang Y, Chen SN, Yang F, Li XY, Feintuch A, Su XC*, Goldfarb* D. In‐cell destabilization of a homodimeric protein complex detected by DEER spectroscopy. Proc. Natl. Acad. Sci USA 2020, 117, 20566‐20575.
Yang Y, Pan BB, Tan X, Yang F, Liu Y*, Su XC*, Goldfarb D*, In‐cell trityl‐trityl distance measurements on proteins. J. Phys. Chem. Lett. 2020, 11, 1141‐1147.
Li M, Ning Y, Chen J, Duan X, Song N, Ding D*, Su X*, Yu Z*. Proline isomerization‐regulated tumor microenvironment‐adaptable self‐assembly of peptides for enhanced therapeutic efficacy. Nano. Lett. 2019, 19, 7965‐79768.
Chen JL, Wang X, Xiao YH, Su XC*. Resonance assignments of lowly populated and unstable enzyme intermediate complex under real‐time conditions. Chembiochem. 2019, 20, 2738‐2742.
Su XC*, Chen JL. Site‐specific tagging of proteins with paramagnetic ions for determination of protein structures in solution and in cells. Acc. Chem. Res. 2019, 52, 1675‐1686.
Pan BB, Yang Y, Liu HZ, Li YH, Su XC*. Coordination of platinum to α‐synuclein inhibits filamentous aggregation in solution. Chembiochem. 2019, 20, 1953‐1958.
Yang Y, Yang F, Li XY, Su XC*, Goldfarb D*. In‐cell EPR distance measurements on ubiquitin labeled with a rigid PyMTA‐Gd(III) tag. J. Phys. Chem B. 2019, 123, 1050‐1059.
Wang X, Chen JL, Otting G, Su XC*. Conversion of an amide to a high‐energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium. Sci. Rep. 2018, 8:16371
Yang Y, Yang F, Gong YJ, Bahrenberg T, Feintuch A, Su XC*, Goldfarb D*. High sensitivity in‐cell EPR distance measurements on proteins using an optimized Gd(III) spin label. J. Phys. Chem. Lett. 2018, 9, 6119‐6123
Chen JL, Zhao Y, Gong YJ, Pan BB, Wang X, Su XC*. Stable and rigid DTPA‐like paramagnetic tags suitable for in vitro and in situ protein NMR analysis. J. Biomol. NMR 2018, 70, 77‐92.
Li X, Wu G, Yang Y, Fu S, Liu X, Kang H, Yang X*, Su XC*, Shen Y*. Calmodulin dissociates the STIM1‐Orial complex and STIM1 oligomers. Nat. Commun. 2017, 8, 1042.
Yang Y, Gong YJ, Litinov A, Liu HK, Yang F, Su XC*, Goldfarb D*. Generic Tags for Mn(II) and Gd(III) spin labels for distance measurements in proteins. Phys. Chem. Chem. Phys. 2017, 19, 26944‐26956.
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