Ke, Yonggang - Georgia Institute of Technology - Wallace H. Coulter Department of Biomedical Engineering

个人简介

Biography Yonggang Ke, PhD, joined the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University in 2014. He is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University. He also holds memberships in the International Society for Nanoscale Science, Computation and Engineering, the Materials Research Society and the Biomedical Engineering Society. Education Dr. Ke received his PhD from Arizona State University. He completed a postdoctoral fellowship at the Dana-Farber Cancer Institute, affiliated with the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School.

研究领域

Dr. Ke's research is highly interdisciplinary combining chemistry, biology, physics, material science, and engineering. The overall mission of his research is to use interdisciplinary research tools to program nucleic-acid-based "beautiful structures and smart devices" at nanoscale, and use them for scientific exploration and technological applications. Specifically, his team focuses on (1) developing new DNA self-assembly paradigms for constructing DNA nanostructures with greater structural complexity, and with controllable sizes and shapes; (2) developing new imaging or drug delivery systems based on DNA nanostructuresl; (3) exploring design of novel DNA-based nanodevices for understanding basic biological questions at molecular level; (4) developing DNA-templated protein devices for constructing artificial bio-reactors. For cancer-related research/application, Dr. Ke will focus on using DNA/RNA nanostructures as drug delivery vehicles. He is also interested in using DNA/RNA nanostructures to study cancer cell biology at molecular level.

近期论文

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Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures. Yu L Cheng J Wang D Pan V Chang S Song J Ke Y, . Journal of the American Chemical Society 2022-05-17 DNA Assembly of Modular Components into a Rotary Nanodevice. Peil A Xin L Both S Shen L Ke Y, Weiss T Zhan P Liu N . ACS nano 2022-03-14 Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array. Fan S Ji B Liu Y Zou K Tian Z Dai B Cui D Zhang P Ke Y, Song J . Angewandte Chemie (International ed. in English) 61 9 e202116324 2022-02-21 Programmable allosteric DNA regulations for molecular networks and nanomachines. Zhang C Ma X Zheng X Ke Y, Chen K Liu D Lu Z Yang J Yan H . Science advances 8 5 eabl4589 2022-02-04 Shaped DNA origami carrier nanopore translocation influenced by aptamer based surface modification. Ding T Yang J Wang J Pan V Lu Z Ke Y, Zhang C . Biosensors & bioelectronics 195 113658 2022-01-01 Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers. Xiong Y Lin Z Mostarac D Minevich B Peng Q Zhu G Sánchez PA Kantorovich S Ke Y, Gang O . Nano letters 21 24 10547-10554 2021-12-22 Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer. Lang L Wang F Ding Z Zhao X Loveless R Xie J Shay C Qiu P Ke Y, Saba NF Teng Y . Journal of experimental & clinical cancer research : CR 40 1 393 2021-12-14 Massively Parallelized Molecular Force Manipulation with On-Demand Thermal and Optical Control. Su H Brockman JM Duan Y Sen N Chhabra H Bazrafshan A Blanchard AT Meyer T Andrews B Doye JPK Ke Y, Dyer RB Salaita K . Journal of the American Chemical Society 143 46 19466-19473 2021-11-24 Monochromatic Fluorescent Barcodes Hierarchically Assembled from Modular DNA Origami Nanorods. Pan V Wang W Heaven I Bai T Cheng Y Chen C Ke Y, Wei B . ACS nano 15 10 15892-15901 2021-10-26 Programmable Site-Specific Functionalization of DNA Origami with Polynucleotide Brushes. Yang Y Lu Q Huang CM Qian H Zhang Y Deshpande S Arya G Ke Y, Zauscher S . Angewandte Chemie (International ed. in English) 60 43 23241-23247 2021-10-18 Mechanically Triggered Hybridization Chain Reaction. Duan Y Glazier R Bazrafshan A Hu Y Rashid SA Petrich BG Ke Y, Salaita K . Angewandte Chemie (International ed. in English) 60 36 19974-19981 2021-09-01 DNA Nanotechnology-Based Biosensors and Therapeutics. Shen L Wang P Ke Y, . Advanced healthcare materials 10 15 e2002205 2021-08-01 DNA-Grafted 3D Superlattice Self-Assembly. Wang S Xie X Chen Z Ma N Zhang X Li K Teng C Ke Y, Tian Y . International journal of molecular sciences 22 14 2021-07-15 DNA origami single crystals with Wulff shapes. Wang Y Dai L Ding Z Ji M Liu J Xing H Liu X Ke Y, Fan C Wang P Tian Y . Nature communications 12 1 3011 2021-05-21 Accurate genotyping of fragmented DNA using a toehold assisted padlock probe. Gao Y Qiao H Pan V Wang Z Li J Wei Y Ke Y, Qi H . Biosensors & bioelectronics 179 113079 2021-05-01 Programmable Transformations of DNA Origami Made of Small Modular Dynamic Units. Wang D Yu L Huang CM Arya G Chang S Ke Y, . Journal of the American Chemical Society 143 5 2256-2263 2021-02-10 Low-Bias Manipulation of DNA Oligo Pool for Robust Data Storage. Gao Y Chen X Qiao H Ke Y, Qi H . ACS synthetic biology 9 12 3344-3352 2020-12-18 Modular Reconfigurable DNA Origami: From Two-Dimensional to Three-Dimensional Structures. Liu Y Cheng J Fan S Ge H Luo T Tang L Ji B Zhang C Cui D Ke Y, Song J . Angewandte Chemie (International ed. in English) 59 51 23277-23282 2020-12-14 DNA Origami Guided Self-Assembly of Plasmonic Polymers with Robust Long-Range Plasmonic Resonance. Wang P Huh JH Park H Yang D Zhang Y Zhang Y Lee J Lee S Ke Y, . Nano letters 20 12 8926-8932 2020-12-09 DNA Origami-Enabled Biosensors. Wang S Zhou Z Ma N Yang S Li K Teng C Ke Y, Tian Y . Sensors (Basel, Switzerland) 20 23 2020-12-03