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个人简介

Tommy was born in Linz, Upper Austria in 1983. In 2002, he moved to Vienna to study chemistry at the University of Vienna. In 2007, he joined the laboratories of Prof. Johann Mulzer and under his guidance he developed enantioselective syntheses of the complex polyketide kendomycin and echinopines A and B. After graduating in 2009, he moved to Harvard University, USA, to begin postdoctoral studies with Prof. Andrew G. Myers. In 2012, he started his independent research as a Liebig-junior research group leader at the LMU Munich. His group has been supported by the Emmy Noether Program of the German Research Foundation (2013–2018) and by a Starting Grant of the European Research Council (2017–2021). In 2017, Tommy was awarded the Goering Visiting Professorship at the University of Wisconsin, Madison and accepted a position as Full Professor of Synthesis and Synthetic Methods at the University of Innsbruck, Austria. Education PhD: University of Vienna (2007–2009) – Johann Mulzer Postdoctoral-Fellow: Harvard University (2010–2012) – Andrew G. Myers

研究领域

Natural products constitute a vast and largely unexplored library of complex molecular architectures, and are a fundamental source for novel pharmaceutical and agricultural agents. However, the complex architecture of these molecules often prevented their application in medicinal chemistry. For us, this is an inspiration to think about new retrosynthetic bond disconnections which are not possible with current methods. The goal is to discover, design and develop novel, highly selective and efficient reactions for synthetic chemists. Mechanistic studies to better understand reactivity and selectivity will be performed when appropriate. These strategies will be applied in the synthesis of biologically relevant complex natural products and simplified analogs thereof. These projects should ultimately provide new lead compounds for the treatment of human diseases, shed light on proposed biosynthetic processes, and help to identify new molecular targets.

近期论文

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Synthesis of (–)-Mitrephorone A via a Bio-inspired Late Stage C–H Oxidation of (–)-Mitrephorone B. L. A. Wein, K. Wurst, P. Angyal, L. Weisheit, T. Magauer*, J. Am. Chem. Soc. 2019, 141, 19589–19593. (PDF) A Synthetic Entry to Polyfunctionalized Molecules through the [3+2]-Cycloaddition of Thiocarbonyl Ylides. F.-L. Haut, C. Habiger, K. Speck, K. Wurst, P. Mayer, J. N. Korber, T. Müller, T. Magauer*, J. Am. Chem. Soc. 2019, 141, 13352−13357. (PDF) Ring-Expansion Approaches for the Total Synthesis of Salimabromide. M. Schmid, A. Grossmann, P. Mayer, T. Müller, T. Magauer*, Tetrahedron 2019, 75, 3195–3215. (PDF) Total Synthesis of Salimabromide, a Tetracyclic Polyketide from a Marine Myxobacterium. M. Schmid, A. Grossmann, K. Wurst, T. Magauer*, J. Am. Chem. Soc. 2018, 140, 8444–8447. (PDF) A Negishi cross-coupling reaction enables the total synthesis of (+)-stachyflin. F.-L. Haut, K. Speck, R. Wildermuth, K. Möller, P. Mayer, T. Magauer*, Tetrahedron., 2018, 74, 3348–3357. (PDF) 9-Membered Carbocycles: Strategies and Tactics for their Synthesis. T. Huber, R. Wildermuth, T. Magauer*, Chem. Eur. J., 2018, 24, 12107–12120. (PDF) De Novo Synthesis of Benzannelated Heterocycles. J. Feierfeil, T. Magauer*, Chem. Eur. J., 2018, 24, 1455–1458. (PDF) A Modular Synthesis of Tetracyclic Meroterpenoid Antibiotics. R. Wildermuth, K. Speck, F.-L. Haut, P. Mayer, B. Karge, M. Brönstrup, T. Magauer*, Nat. Commun., 2017, 8, 2083. (PDF) Development of a β-C–H Bromination Approach Towards the Synthesis of Jerantinine E. T. Huber, T. Unzner, C. Gerlinger, T. Magauer*, J. Org. Chem., 2017, 82, 7410–7419. (PDF) Dyotropic Rearrangements in Natural Product Synthesis and Biosynthesis. C. L. Hugelshofer, T. Magauer*, Nat. Prod. Rep., 2017, 34, 228–234. (Highlight) (PDF) Bioinspired Total Syntheses of Terpenoids. C. L. Hugelshofer, T. Magauer*, Org. Biomol. Chem. 2017, 15, 12–16. (Perspective) (PDF) Evolution of a Polyene Cyclization Cascade for the Total Synthesis of (–)-Cyclosmenospongine.K. Speck, T. Magauer*, Chem. Eur. J. 2017, 23, 1157–1165. (HOT PAPER) (PDF) Convergent Assembly of the Tetracyclic Meroterpenoid (–)-Cyclosmenospongine via a Non-Biomimetic Polyene Cyclization.K. Speck, R. Wildermuth, T. Magauer*, Angew. Chem. Int. Ed. 2016, 55, 14131–14135. (PDF) A Divergent Approach to the Marine Diterpenoids (+)-Dictyoxetane and (+)-Dolabellane V. C. L. Hugelshofer, T. Magauer*, Chem. Eur. J. 2016, 22, 15125–15136. (PDF) Rapid Access to Orthogonally Functionalized Naphthalenes: Application to the Total Synthesis of the Anticancer Agent Chartarin. T. A. Unzner, A. Grossmann, T. Magauer*, Angew. Chem., Int. Ed. 2016, 55, 9763–9767. (HOT PAPER) (PDF) A Bioinspired Cyclization Sequence Enables the Asymmetric Total Synthesis of Dictyoxetane. C. L. Hugelshofer, T. Magauer*, J. Am. Chem. Soc. 2016, 138, 6420–6423. (PDF) This work was highlighted in SYNFACTS: E. M. Carreira, H. Wolleb, Synfacts 2016, 12, 771. Gold(I)-Catalyzed Enyne Cyclizations: Studies Towards the Total Synthesis of (+)-Aureol. R. Wildermuth, K. Speck, T. Magauer*, Synthesis, 2016, 48, 1814–1824. (PDF) Trihaloethenes as Versatile Building Blocks for Organic Synthesis.A. Grossmann, T. Magauer*, Org. Biomol. Chem. 2016, 14, 5377–5389 (Review). (PDF) Synthesis of Xenia diterpenoids and related metabolites isolated from marine organisms. T. Huber, L. Weisheit, T. Magauer*, Beilstein J. Org. Chem. 2015, 11, 2521–2539 (Review). (PDF) Ring Opening of Bicyclic[3.1.0]hexan-2-ones: A Versatile Synthetic Platform for the Construction of Substituted Benzoates. J. Feierfeil, A. Grossmann, T. Magauer*, Angew. Chem., Int. Ed. 2015, 54, 11835–11838. (PDF) The 50th EUCHEM Conference on Stereochemistry (Bürgenstock Conference 2015).A. Adibekian, T. Magauer*, Chimia, 2015, 69, 485–487 (Conference Report). (PDF)

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