刘宗亮 - 烟台大学

研究领域

靶向抗肿瘤药物开发研究，主要是针对于酪氨酸蛋白激酶CK2，通过CADD设计全新的选择性小分子抑制剂，合成含特异性母环的化合物进行药理活性筛选，发现具有研究的价值的先导化合物，进行进一步的结构优化和构效关系研究。

近期论文

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1.Zong-LiangLiu,Xiao-JianWang,Nian-GuangLi,Hao-PengSun,Jin-XinWang,Qi-DongYou“Totalsynthesisofaldehyde-containingGarcinianaturalproductsisomorellinandgaudichaudioneA”,Tetrahedron,67(2011)4774-4779(ImpactFactor:3.219). 2.Hao-PengSun,Zong-LiangLiu,YuanGao,LeiZhang,Jin-XinWang,Oing-LongGuo,Qi-DongYou.“Studiesonchemicalstructuremodificationandstructure–activityrelationshipofGAderivativesatC39”.CHEMISTRY&BIODIVERSITY，Vol.9(2012)1579-1590(ImpactFactor:1.5). 3.Hao-pengSun,Fei-HongChen,Xiao-JianWang,Zong-LiangLiu,QianYang,Xiao-JinZhang,JiaZhu,LeiQiang,Qing-LongGuo,andQi-DongYou.“Studiesonchemicalmodificationandbiologyofanaturalproduct,Gambogicacid(IV):IdentificationofIκBKinase-beta(IKKβ)asthemoleculartargetanddeterminationofthepharmacophoricscaffold”.EuropeanJournalofMedicinalChemistry,51(2012)110-123(ImpactFactor:3.269). 4.DanXu,Xian-FangXu,Zong-LiangLiu，Li-PingSun,Qi-DongYou.“Ageneralandefficientsynthesisof2-substitutedozazolopyridines”.Synlett,2009,No.7,1172–1174(ImpactFactor:2.718). 5.HaopengSun,XiaoliXu,XiaowenWu,XiaojinZhang,FangLiu,JianminJia,XiaokeGuo,JingjieHuang,ZhengyuJiang,TaotaoFeng,HongxiChu,YouZhou,ShenglieZhang,ZongliangLiu,andQidongYou.DiscoveryandDesignofTricyclicScaffoldsasProteinKinaseCK2(CK2)InhibitorsthroughaCombinationofShape-BasedVirtualScreeningandStructure-BasedMolecularModification.JournalofChemicalInformationandModeling,2013,53,2093−2102(ImpactFactor:4.304).