研究领域

研究方向为长效缓控释制剂、经鼻脑靶向制剂等新型给药系统研究。 主要研究内容包括罗替戈汀等中枢神经系统药物长效缓释微球的研究；长效微晶缓释制剂的研究；经鼻脑靶向制剂的研究。

基于持续多巴胺能刺激治疗帕金森病的长效释药系统的构建及其机制研究（ZR2013HQ009） 山东省自然基金 基于冰片药引的双级经鼻脑靶向纳米递药系统的构建及治疗帕金森病研究（ZR2017LH076） 山东省自然基金 基于树枝状聚合物PAMAM的葛根素眼部递药系统的构建及其角膜作用机制研究（30873447） 国家自然基金 注射用石杉碱甲长效缓释微球（2009ZX09102-125） 国家“十一五”科技重大专项

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(1)LiuxiangChu#,AipingWang#*,LingNi,XiujuYan,YinaSong,MingyuZhao,KaoxiangSun*,HongjieMu,ShaLiu,ZimeiWu,ChunyanZhang.Nose-to-braindeliveryoftemozolomide-loadedPLGAnanoparticlesfunctionalizedwithanti-EPHA3forglioblastomatargeting.Drugdelivery,2018,25(1):1634–1641 (2)DongyuDuan#,AipingWang#,LingNi,LipingZhang,XiujuYan,YingJiang,HongjieMu,ZimeiWu,KaoxiangSun*,YouxinLi*.Trastuzumab-andFab′fragment-modifiedcurcuminPEG-PLGAnanoparticles:preparationandevaluationinvitroandinvivo.InternationalJournalofNanomedicine,2018:131831–1840. (3)XiujuYan#,LixiaoXu#,ChenchenBi,DongyuDuan,LiuxiangChu,XinYu,ZimeiWu,AipingWang*,KaoxiangSun*.Lactoferrin-modifiedrotigotinenanoparticlesforenhancednose-to-braindelivery:LESA-MS/MS-baseddrugbiodistribution,pharmacodynamics,andneuroprotectiveeffects.InternationalJournalofNanomedicine,2018,13:273-281. (4)YingJiang,XuemeiZhang,HongjieMu,HongchenHua,DongyuDuan,XiujuYan,YiyunWang,QingqingMeng,XiaoyanLu,AipingWang*,WanhuiLiu,YouxinLi,KaoxiangSun*.PreparationandevaluationofinjectableRasagilinemesylatedual-controlleddrugdeliverysystemforthetreatmentofParkinson'sdisease.,2018,25(1):143-152. (5)QingqingMeng#,AipingWang#*,HongchenHua,YingJiang,YiyunWang,HongjieMu,ZimeiWu,KaoxiangSun*.IntranasaldeliveryofHuperzineAtothebrainusinglactoferrin-conjugatedN-trimethylatedchitosansurface-modifiedPLGAnanoparticlesfortreatmentofAlzheimer’sdisease.InternationalJournalofNanomedicine,2018,13:705–718. (6)YongchaoChu,NingChen,HuajunYu,HongjieMu,BinHe,HongchenHua,AipingWang*,KaoxiangSun*.Topicaloculardeliverytolaser-inducedchoroidalneovascularizationbydualinternalizingRGDandTATpeptide-modifiednanoparticles.InternationalJournalofNanomedicine,2017,12:1353-1368. (7)ChenchenBi#,AipingWang#,YongchaoChu,ShaLiu,HongjieMu,WanhuiLiu,ZimeiWu,KaoxiangSun*,YouxinLi*.Intranasaldeliveryofrotigotinetothebrainwithlactoferrin-modifiedPEG-PLGAnanoparticlesforParkinson’sdiseasetreatment.InternationalJournalofNanomedicine,2016,11:6547-6559. (8)AipingWang,YanxiangLiu,RongcaiLiang,XuemeiZhang,KaoxiangSun,ZimeiWu,WanhuiLiu*.Preparationandevaluationofrotigotine-loadedimplantforthetreatmentofParkinson’sdiseaseanditsevolutionstudy.SaudiPharmaceuticalJournal,2016,24(3):363–370. (9)AipingWang,RongcaiLiang,WanhuiLiu,ChunjieSha,YouxinLi,KaoxiangSun*.Effectofpalmiticacidonthecharacteristicsandreleaseprofilesofrotigotine-loadedmicrospheres.PharmaceuticalDevelopmentandTechnology,2016,21(1):3-7. (10)AipingWang#,LexiWang#,KaoxiangSun,WanhuiLiu,ChunjieSha,YouxinLi*.PreparationofrotigotineloadedmicrospheresandtheircombinationusewithL-DOPAtomodifydyskinesiasin6-OHDA-lesionedrats.PharmaceuticalResearch,2012,29(9):2367-2376.