个人简介

2018.07-至今，烟台大学-药学院，副教授 2014.05-2018.04，美国食品药品监督管理局（U.S.FDA），ORISEFellow 2013.11-2014.05，美国加州大学圣地亚哥分校（UCSD），博士后 2013.07–2013.10，天津医科大学总医院，研究助理 2010.09–2013.06，南开大学，生物化学与分子生物学，博士

研究领域

1．新型纳米药物的分子药理学研究 2．药物和功能性食品的毒理学评价

1．线粒体靶向缓释微球PLGA-(TEMPO+TPP-Ceria)对视网膜缺血再灌注损伤的作用及机制研究（81970826），国家自然科学基金面上项目，项目负责人 2．IL-10修饰的骨髓来源的神经干细胞对视网膜缺血再灌注损伤的作用及机制的研究（81500743），国家自然科学基金青年项目，项目负责人 3．VEGI对糖尿病视网膜病变的区域免疫炎性微环境调控作用及分子机制的研究（91442124），国家自然科学重大研究项目培育计划，第一参与人 4．PD-1/PD-L1对年龄相关性黄斑变性发展的影响及免疫机制的研究（81670865），国家自然科学基金，第二参与人 5．IL-10修饰的内皮祖细胞对非增生期糖尿病视网膜病变发展的影响和分子机制的研究（81371038），国家自然科学基金面上项目，第二参与人 授权专利： 1.miR-885-5p在制备判断原发性肝癌临床分期的诊断试剂中的用途，ZL201210222211.0 2.一种抑制原发性肝癌生长和转移的新方法，ZL201210222212.5

近期论文

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1.ZhangZ,RenZ,ChenS,GuoX,LiuF,GuoL,MeiN.ROSgenerationandJNKactivationcontributeto4-methoxy-TEMPO-inducedcytotoxicity,autophagy,andDNAdamageinHepG2cells.ArchivesofToxicology92(2):717-728(IF:5.9,JCR分区:医学1区) 2.ZhangZ,YinJ,YangJ,ShenW,ZhangC,MouW,LuoJ,YanH,SunP,LuoY,TianY,XiangR.miR-885-5psuppresseshepatocellularcarcinomametastasisandinhibitsWnt/β-cateninsignalingpathway.Oncotarget7(46):75038-75051(2016).(IF:5.2,JCR分区:医学1区) 3.ZhangZ,ChenS,MeiH,XuanJ,GuoX,CouchL,DobrovolskyVN,GuoL,MeiN.GinkgobilobaleafextractinducesDNAdamagebyinhibitingtopoisomeraseIIactivityinhumanhepaticcells.ScientificReports5:14633(2015).(IF:4.3,JCR分区:综合2区) 4.ZhangZ,YinJ,ZhangC,LiangN,BaiN,ChangA,LiuY,LiZ,TanX,LiN,LvD,XiangR,TianY,LiuC.Activatingtranscriptionfactor4increaseschemotherapeuticsresistanceofhumanhepatocellularcarcinoma.CancerBiology&Therapy13(6):435-442(2012).(IF:3.3,JCR分区:医学3区) 5.ZhangZ,ChenQ,TownsendTA,MaoC,YouC,YangW,SunZ,YuJ,YanH.ChangesinTL1Alevelsandassociatedcytokinesduringpathogenesisofdiabeticretinopathy.MolecularMedicineReports15(2):573-580(2016).(IF:1.7,JCR分区:医学4区) 6.ZhangZ,LiH,ManjanathaMG,ChenT,MeiN.Neonatalexposureof17β-estradiolhasnoeffectsonmutagenicityof7,12-dimethylbenz[a]anthraceneinreproductivetissuesofadultmice.GenesandEnvironment37:16(2015).（新杂志） 7.ChenS*,ZhangZ*(co-firstauthor),WuY,ShiQ,YanH,MeiN,TollesonWH,GuoL.Endoplasmicreticulumstressandstore-operatedcalciumentrycontributetousnicacid-inducedtoxicityinhepaticcells.ToxicologicalSciences146(1):116-26(2015).(IF:4.1,JCR分区:医学2区) 8.ZhengH*,ZhangZ*(co-firstauthor),LuoN,LiuY,ChenQ,YanH.IncreasedTh17cellsandIL-17inratswithtraumaticopticneuropathy.MolecularMedicineReports10(4):1954-8(2014).(IF:1.559,JCR分区:医学4区) 9.ZhangY*,ZhangZ*(co-firstauthor),YanH.Simvastatininhibitsischemia/reperfusioninjury-inducedapoptosisofretinalcellsviadownregulationofthetumornecrosisfactor-α/nuclearfactor-κBpathway.InternationalJournalofMolecularMedicine36(2):399-405(2015).(IF:2.3,JCR分区:医学3区) 10.ChenS,ZhangZ,QingT,RenZ,YuD,CouchL,NingB,MeiN,ShiL,TollesonWH,GuoL.ActivationoftheNrf2signalingpathwayinusnicacid-inducedtoxicityinHepG2cells.ArchivesofToxicology91(3):1293-1307(2017).(IF:6.637,JCR分区:医学1区) 11.YangJ,ZhangZ,ChenC,LiuY,SiQ,ChuangTH,LiN,Gomez-CabreroA,ReisfeldRA,XiangR,LuoY.MicroRNA-19a-3pinhibitsbreastcancerprogressionandmetastasisbyinducingmacrophagepolarizationthroughdownregulatedexpressionofFra-1proto-oncogene.Oncogene33(23):3014-23(2014).(IF:7.5,JCR分区:医学2区 12.ZhangS,CuiB,LaiH,LiuG,GhiaEM,WidhopfGF2nd,ZhangZ,WuCC,ChenL,WuR,SchwabR,CarsonDA,KippsTJ.OvariancancerstemcellsexpressROR1,whichcanbetargetedforanti-cancer-stem-celltherapy.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica111(48):7266-71(2014).(IF:9.7,JCR分区:综合1区) 13.FangS,MengX,ZhangZ,WangY,LiuY,YouC,YanH.VorinostatmodulatestheimbalanceofTcellsubsets,suppressesmacrophageactivity,andamelioratesexperimentalautoimmuneuveoretinitis.NeuromolecularMedicine18(1):134–145(2016).(IF:3.692,JCR分区:医学2区) 14.JiangF,ChenQ,HuangL,WangY,ZhangZ,MengX,LiuY,MaoC,ZhengF,ZhangJ,YanH.TNFSF15inhibitsbloodretinalbarrierbreakdowninducedbydiabetes.InternationalJournalofMolecularSciences17(5):615(2016).(IF:3.252,JCR分区:化学3区) 15.MengX,FangS,ZhangZ,WangY,YouC,ZhangJ,YanH.PreventiveeffectofchrysinonexperimentalautoimmuneuveitistriggeredbyinjectionofhumanIRBPpeptide1–20inmice.Cellular&MolecularImmunology14(8):702-711(2017).(IF:5.193,JCR分区:医学2区) 16.LiuY,YouC,ZhangZ,ZhangJ,YanH.RolesofTreg/Th17cellimbalanceandneuronaldamageinthevisualdysfunctionobservedinexperimentalautoimmuneopticneuritischronologically.NeuromolecularMedicine17(4):391-403(2015).(IF:3.692,JCR分区:医学2区) 17.GuoX,ChenS,ZhangZ,DobrovolskyVN,DialSL,GuoL,MeiN.Reactiveoxygenspeciesandc-JunN-terminalkinasescontributetoTEMPO-inducedapoptosisinL5178Ycells.Chemico-BiologicalInteractions235:27-36(2015).(IF:2.618,JCR分区:生物3区) 18.WangY,ChenQ,ZhangZ,JiangF,MengX,YanH.Interleukin-10overexpressionimprovesthefunctionofendothelialprogenitorcellsstimulatedwithTNF-αthroughtheactivationoftheSTAT3signalingpathway.InternationalJournalofMolecularMedicine35(2):471-7(2015).(IF:2.348,JCR分区:医学3区) 19.ChenS,DobrovolskyVN,LiuF,WuY,ZhangZ,MeiN,Theroleofautophagyinusnicacid-inducedtoxicityinhepaticcells.ToxicologicalSciences142(1):33-44(2014).(IF:3.88,JCR分区:医学2区) 20.BaiN,ZhangC,LiangN,ZhangZ,ChangA,YinJ,LiZ,LuoN,TanX,LuoN,LuoY,XiangR,LiX,ReisfeldRA,StupackD,LvD,LiuC.Yes-associatedprotein(YAP)increaseschemosensitivityofhepatocellularcarcinomacellsbymodulationofp53.CancerBiology&Therapy14(6):511-20(2013).(IF:2.921,JCR分区:医学3区

学术兼职

担任以下国际期刊审稿人： ToxicologyandAppliedPharmacology JournalofFoodandDrugAnalysis OMICSPublishingGroup/ACR Neoplasm PLoSONE JournalofEnvironmentalScienceandHealth,PartC(JESH-C) BioMedResearchInternational OncoTargetsandTherapy InternationalMedicalCaseReportsJournal ToxicologyinVitro