肖文精 - 华中师范大学

个人简介

Education 2001-2002, Postdoctoral scholar, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena (Advisor: Prof. David W.C. MacMillan). 1997-2000, Ph.D., Department of Chemistry, University of Ottawa, Canada (Advisor: Prof. Howard Alper). 1995-1996, Ph.D., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (Advisor: Prof. Xi-Yan Lu). 1987-1990, M.Sc., Institute of Pesticide Chemistry, Central China Normal University(Advisor: Prof. Wen-Fang Huang). 1980-1984, B.S., Chemistry Department, Central China Normal University(Advisor: Prof. Kai-Qing Tang). Career 2014.6 until now, Dean of College of Chemisty, Central China Normal University, Distinguished Professor of Liberal Arts Scholars. 2003.9-2014.6, Professor and doctoral supervisor of Central China Normal University, Guizi Scholar Distinguished Professor. 2002.2-2003.8, Chief Scientist, Materia, Inc., Pasadena, CA, USA. 2001.1-2002.1, Postdoctoral Fellow, Department of Chemistry, California Institute of Technology. 1997.9-2000.12, Teaching/Research Assistant, Department of Chemistry, University of Ottawa, Canada. 1996.3-1997.8, Visiting Scholar, Department of Chemistry, University of Ottawa, Canada. 1994.10-1996.3, Associate Professor, Institute of Pesticide Chemistry, Central China Normal University, China. 1990.4-1994.9, Lecturer, Institute of Pesticide Chemistry, Central China Normal University, China. 1984.7-1990.3, Teaching Assistant, Institute of Pesticide Chemistry, Central China Normal University, China.

研究领域

Photochemical Synthesis Organic Radical Chemistry Asymmetric Catalysis Mechanistic Study

近期论文

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Asymmetric Radical Coupling to Form β2,2,3-Amino Acid Esters by Synergistic Chiral Phosphoric Acid and Photocatalysis Zi-Wei He, Bao-Ru Yuan, Xiao-Ye Yu, Min Jiang, Jia-Rong Chen, and Wen-Jing Xiao*10.1002/anie.202514155 Heterogeneous Catalysts for Toluene Oxidation Zhen Su, Hua Long, Rui-Rui Zhao, Ke Gao* and Wen-Jing Xiao*10.1002/asia.202500530 Heterogeneous difunctional organic polymers with 2,2,6,6- tetramethylpiperidinyloxy and N-methylimidazole for selective oxidation of alcohols Wencheng Wang, Ruirui Zhao, Fang Hu, Konstantin N. Gavrilovc, Zhen Su*, Ke Gao, Liang-Qiu Lu, Ying Cheng**, Wenjing Xiao 10.1016/j.gresc.2025.05.009 Asymmetric [3 + 2] Annulation of N-Sulfonyl Ketimines and Alkynes via Synergistic Photoredox/Cobalt Catalysis Wei Xiong†, Rui-Rui Zhao†, Hui-Shuang Wang, Liang-Qiu Lu, Ke Gao* and Wen-Jing Xiao*10.31635/ccschem.025.202505699 Pd-catalyzed asymmetric (6+2) dipolar cyclization for medium-sized spirooxindoles Yu-Qing Xiao, Zi-Qing Li, Fang Hu, Tian-Yu Li, Zheng-Xin Zhou, Zhihan Zhang, Ying Tan, Wen-Jing Xiao, Konstantin Nikolaevich Gavrilov* and Liang-Qiu Lu*10.1039/d5cc02323h Heterogeneous Organic Polymers Embedded with Chiral Bisoxazoline Ligands for Photoinduced Cu-Catalyzed Asymmetric Cyanation Ren-Jie Yu,‡ Rui-Rui Zhao,‡ Fang Hu, Zhen Su,* Ke Gao,* Liang-Qiu Lu,* Wen-Jing Xiao 10.1002/cjoc.70052 Unlocking Epoxide Radical Anion Reactivity for Asymmetric Cross-Coupling by Copper Metallaphotoredox Fan Teng, Zi-Qing Li, Zhi-Cheng Mao, Zhihan Zhang, Min Jiang, Wen-Jing Xiao, Jia-Rong Chen*10.1021/jacs.5c05957 Construction of planar chiral [2,2]paracyclophanes via photoinduced cobalt-catalyzed desymmetric addition Shi-Qi Liu#, Wei Xiong#, Ji-Chao Huang, Xuan Jiang, Wenhan Xu, Zhihan Zhang, Ying Cheng, Liang-Qiu Lu, Ke Gao*, Wen-Jing Xiao*10.1038/s41467-025-59089-3 Enantioselective macrocyclization via catalytic metallic dipole relay Bao-Le Qu#, Meng Xiao#, Lin He, Jun-Wei Shi, Zhihan Zhang*, Wen-Jing Xiao & Liang-Qiu Lu*10.1038/s41929-025-01322-9 Enantioselective synthesis of chiral N-arylpyrroles through photoinduced desymmetrization Zi-Wei He, Dong Liang, Jia-Rong Chen, Ying Cheng*, Wen-Jing Xiao 10.1016/j.gresc.2025.03.001 Photocatalytic Strecker-Type Reaction for the Synthesis of Primary α-Aminonitriles Guo-Feng Li, Peng-Zi Wang, Wen-Jing Xiao, and Jia-Rong Chen*10.1021/acs.orglett.5c00491 Stereocontrol Strategies in Asymmetric Organic Photochemical Synthesis Xuan Jiang†, Xu Han†, Fu-Dong Lu, Liang-Qiu Lu*, Zhiwei Zuo* and Wen-Jing Xiao*10.31635/ccschem.025.202505512 Photobiocatalytic Reaction:From Single Component toTriple Component Rui-Tao Sun, Peng Chen, Sheng-Zhen Xu*, Liang-Qiu Lu*, Wen-Jing Xiao*10.1002/anie.202502489 Direct Asymmetric α-Alkylationof β-Ketocarbonyl Compounds with Simple Olefins by Photoredox-Nickel-Hydrogen Atom Transfer Triple Catalysis Xue-Song Zhou, Zi-Qing Li, Wen-Yuan Qu, Zhihan Zhang, Wen-Jing Xiao, and Jia-Rong Chen*10.1002/anie.202424915 New pathway under light: conversion of furans to pyrroles Yue-Liu-Ting Fu#, Jun-Wei Shi#, Peng Chen, Wen-Jing Xiao, Liang-Qiu Lu*10.1016/j.scib.2025.01.061 Modular Synthesis of Planar-Chiral Cyclononenes via trans-Retentive Trapping of π-Allyl-Pd Dipoles Zheng-Xin Zhou, Yue-Liu-Ting Fu, Chen Zhang, Yuan-Heng Li, Bin-Jun Zhang, Yu-Qing Xiao, Yu-Jie Li, Li-Yan Chen, Li Rao*, Ying Tan*, Wen-Jing Xiao, Liang-Qiu Lu*10.1021/jacs.4c12892 Photocatalysis Meets Copper Catalysis: A New Opportunity for Asymmetric Multicomponent Radical Cross-Coupling Reactions Peng-Zi Wang, Bin Zhang, Wen-Jing Xiao, and Jia-Rong Chen*10.1021/acs.accounts.4c00638 Synthesis of chiral spiro-indenes via Pd-catalyzed asymmetric (4 + 2) dipolar cyclization Lin He, Bao-Le Qu, Meng Xiao, Jia-Qin Yu, Jie Yu, Ying Cheng, Zhihan Zhang, Wen-Jing Xiao,Liang-Qiu Lu*DOI: 10.20517/cs.2024.39 Photoinduced Hydrosilylation of Fluorinated Alkenes Bao-Ru Yuan, Xiang-Kui He, Ying Cheng* and Wen-Jing Xiao* 10.1021/acs.orglett.4c03289 Synthesis of Chiral Endocyclic Allenes and Alkynes via Pd-Catalyzed Asymmetric Higher-Order Dipolar Cycloaddition Bin Shi#, Meng Xiao#, Jin-Pu Zhao, Zhihan Zhang*, Wen-Jing Xiao, and Liang-Qiu Lu*10.1021/jacs.4c10328 Formation of Chiral All-Carbon Quaternary Stereocenters by Photoinduced Cobalt-Catalyzed Enantioselective Radical Coupling Yue Jia#, Kai Zhang#, Liang-Qiu Lu, Ying Cheng*, and Wen-Jing Xiao* 10.1021/acscatal.4c04249 Photoinduced Copper-Catalyzed Three-Component Radical Carboamination of Styrene Derivatives Xiao-Die Huan, Juan Zhang, Wen-Jing Xiao, and Jia-Rong Chen* 10.1002/cctc.202401234 Access to N-α-quaternary chiral morpholines via Cu-catalyzed asymmetric propargylic amination/desymmetrization strategy Peng Chen#, Mao-Mao Zhang#, Li Rao，Yuan-Heng Li, Yue Jia, Ying Tan, Wen-Jing Xiao, Liang-Qiu Lu* 10.1016/j.scib.2024.08.005 Hyperconjugation-Driven Isodesmic Reaction of Indoles and Anilines: Reaction Discovery, Mechanism Study, and Antitumor Application Yu-Qing Xiao#, Kai-Xin Fang#, Zhihan Zhang#, Chen Zhang, Yu-Jie Li, Bao-Cheng Wang, BinJun Zhang, Yu-Qing Jiang, Miao Zhang, Ying Tan,* Wen-Jing Xiao, and Liang-Qiu Lu* 10.1002/anie.202408426 Asymmetric Radical Allylation of β-Keto Esters with Vinyl Cyclopropanes by Dual Photoredox/Nickel Catalysis Wen-Yuan Qu, Xue-Song Zhou, Wen-Jing Xiao*, Jia-Rong Chen* 10.1007/s11426-024-2249-x A General Copper-Box System for the Asymmetric Arylative Functionalization of Benzylic, Propargylic or Allenylic Radicals Peng-Zi Wang, Zhihan Zhang, Min Jiang, Jia-Rong Chen, Wen-Jing Xiao*10.1002/anie.202411469 Recent advances in C(sp3)–N bond formation via metallaphoto-redox catalysis Juan Zhang,* Xiao-Die Huan, Xin Wang, Guo-Qing Li, Wen-Jing Xiao and Jia-Rong Chen*10.1039/D4CC01969E Desymmetrization−Addition Reaction of Cyclopropenes to Imines via Synergistic Photoredox and Cobalt Catalysis Xiang-Kui He,⊥ Liang-Qiu Lu,⊥ Bao-Ru Yuan, Jia-Long Luo, Ying Cheng, and Wen-Jing Xiao*10.1021/jacs.4c07096 Photoinduced Copper-Catalyzed Asymmetric Three-Component Radical 1,2-Azidooxygenation of 1,3-Dienes Guo-Qing Li, Zi-Qing Li, Min Jiang, Yu Qian, Zhihan Zhang, Wen-Jing Xiao, and Jia-Rong Chen*10.1002/anie.202405560 Synthesis of S(IV)-Stereogenic Chiral Thio-Oxazolidinones via Palladium-Catalyzed Asymmetric [3+2] Annulations Bao-Cheng Wang+, Fang Hu+, Jiahui Bai+, Fen-Ya Xiong, Peng Chen, Jianye Li, Ying Tan, Yin-Long Guo,* Wen-Jing Xiao, and Liang-Qiu Lu*10.1002/anie.202319728 Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes Bin Lu,‡ Feng-Shuo Bao,‡ Zi-Wei He, Wen-Jing Xiao and Jia-Rong Chen*10.1002/cjoc.202300733 Asymmetric Cascade Cyclization of Enynamides with Photogenerated Ketenes via Relay Gold and N-Oxide Catalysis Dan Liu,# Zhen-Cao Shu,# Zhihan Zhang,# Ze-Tian Wang, Liang Wang, Ming-Sheng Xie,* Hai-Ming Guo, Liang-Qiu Lu,* and Wen-Jing Xiao*10.1021/acscatal.3c05731 Controlled generation of ortho-quinone methides and (4+3) cyclization with 2indolylalcohols by dual photoredox/Brønsted acid relay catalysis Dong Liang, Pan-Pan Gao, Zhihan Zhang, Wen-Jing Xiao, Jia-Rong Chen* 10.1016/j.gresc.2024.01.002 Enantioselective Cyanofunctionalization of Aromatic Alkenes via Radical Anions Bin Zhang, Tian-Tian Li, Zhi-Cheng Mao, Min Jiang, Zhihan Zhang, Ke Zhao, Wen-Yuan Qu, Wen-Jing Xiao*, and Jia-Rong Chen* 10.1021/jacs.3c10439 Visible Light Induced Copper-Catalyzed Enantioselective Deaminative Arylation of Amino Acid Derivatives Assisted by Phenol Yue Jia#， Zhihan Zhang#， Guo-Ming Yu, Xuan Jiang*， Liang-Qiu Lu* and Wen-Jing Xiao* DOI：10.1002/anie.202312102 Copper-Catalyzed Asymmetric Radical 1,2-Alkylesterification of 1,3-Dienes with Cycloalkyl Hydroperoxides and Acids Tian-Tian Li, Ying Cheng, Wen-Jing Xiao, De-Qing Shi*, Jia-Rong Chen* DOI: 10.1002/cctc.202301068 Photoinduced Five-Component Radical Relay Aminocarbonylation of Alkenes Bin Lu, Zhihan Zhang, Min Jiang, Dong Liang, Zi-Wei He, Feng-Shuo Bao, Wen-Jing Xiao, and Jia-Rong Chen* DOI: 10.1002/anie.202309460 Emerging Trends in Copper-Promoted Radical-Involved C–O Bond Formations Peng-Zi Wang, Jia-Rong Chen*, and Wen-Jing Xiao* DOI: 10.1021/jacs.3c04879 Diradical ring formation Peng-Zi Wang and Jia-Rong Chen* 10.1038/s41557-023-01263-5 Photoinduced carbene transfer for copper-catalyzed asymmetric [4 + 1] cycloadditions: an entry to chiral indolines bearing quaternary stereocenters Bao-Le Qu, Bin Shi, Lin He, Jun-Wei Shi, Wen-Jing Xiao and Liang-Qiu Lu* 10.1039/D3QO00551H Photoinduced copper-catalyzed asymmetric radical three-component cross-coupling of 1,3-enynes with oxime esters and carboxylic acids Guo-Qing Li, Fan-Rong Meng, Wen-Jing Xiao and Jia-Rong Chen* DOI: 10.1039/D3QO00513E Asymmetric [3 + 2] Photocycloaddition of β-Keto Esters and Vinyl Azides by Dual Photoredox/Nickel Catalysis Xue-Song Zhou, Zhihan Zhang, Wen-Yuan Qu, Xiao-Peng Liu, Wen-Jing Xiao,* Min Jiang,* and Jia-Rong Chen*DOI:10.1021/jacs.3c02485 Electrochemical Reactors Enable Divergent Site Selectivity in the C-H Carboxylation of N-Heteroarenes Peng-Zi Wang, Wen-Jing Xiao*, and Jia-Rong Chen*DOI: 10.1002/anie.202302227 Dynamic Kinetic Reductive Conjugate Addition for Construction of Axial Chirality Enabled by Synergistic Photoredox/Cobalt Catalysis Wei Xiong,# Xuan Jiang,# Wen-Cheng Wang, Ying Cheng, Liang-Qiu Lu, Ke Gao,* and Wen-Jing Xiao*DOI: 10.1021/jacs.2c13538 Dearomatization-Rearomatization Reaction of Metal-Polarized Aza-ortho-Quinone Methides Bao-Cheng Wang,‡ Li Rao,‡ Kai-Xin Fang,‡ Bao-Le Qu, Fen-Ya Xiong, Ying Feng, Ying Tan,* Liang-Qiu Lu,* Wen-Jing Xiao DOI: 10.1002/anie.202301592 Advances in the construction of axially chiral biaryl-contained medium-sized rings via asymmetric catalysi Baole Qu, Lin He, Junwei Shi, Liangqiu Lu*, Wenjing Xiao,*DOI: 10.1360/SSC-2022-0244 Photoinduced Cobalt-Catalyzed Desymmetrization of Dialdehydes to Access Axial Chirality Hao Jiang,‡ Xiang-Kui He,‡ Xuan Jiang,‡ Wei Zhao, Liang-Qiu Lu, Ying Cheng,* and Wen-Jing Xiao*DOI: 10.1021/jacs.3c00462 Cobalt-Catalyzed Asymmetric Phospha-Michael Reaction of Diarylphosphine Oxides for the Synthesis of Chiral Organophosphorus Compounds Yu, X.-H.; Lu, L.-Q.; Zhang, Z.-H.; Shi, D.-Q.* and Xiao, W.-J. Org. Chem. Front., 2022, Article ASAP DOI: 10.1039/D2QO01483A Taming Chiral Quaternary Stereocenters via Remote H-Bonding Stereoinduction in Palladium-Catalyzed (3+2) Cycloadditions Xiao, Y.-Q.; Li, M.-M.; Zhou, Z.-X.; Li, Y.-J.; Cao, M.-Y.; Liu, X.-P.; Lu, H.-H.; Li, R.; Lu, L.-Q.*; Beauchemin, A. M. and Xiao, W.-J. Angew. Chem. Int. Ed. 2022, In press. DOI: 10.1002/anie.202212444 Light-empowered contra-thermodynamic stereochemical editing Wang, P.-Z.; Xiao, W.-J.*; Chen, J.-R.* Nature Reviews Chemistry, 2022, In press. DOI: 10.1038/s41570-022-00441-2 Construction of axially chiral compounds via catalytic asymmetric radical reaction Liang, D.; Xiao, W.-J.; Sami, L.* and Chen, J.-R.* Green Synthesis and Catalysis 2022, 3, 212-218. DOI: 10.1016/j.gresc.2022.06.003 De Novo Construction of Chiral Aminoindolines by Cu-Catalyzed Asymmetric Cyclization and Subsequent Discovery of an Unexpected Sulfonyl Migration Wang, B.-C.; Fang, T.-T.; Xiong, F.-Y.; Chen, P.; Fang, K.-X.; Tan, Y.*; Lu, L.-Q.* and Xiao, W.-J. J. Am. Chem. Soc. 2022, ASAP. DOI: 10.1021/jacs.2c08090 Visible-Light-Induced Photoredox-Catalyzed Selective 1,4-Difluoroalkylesterification of 1-Aryl-1,3-dienes Bi, M.-H.;Cheng, Y.; Xiao, W.-J. and Chen, J.-R.* Org. Lett., 2022, 24, 7589-7594. DOI: 10.1021/acs.orglett.2c03020 Selective Three-Component 1,2-Aminoalkoxylation of 1-Aryl-1,3-dienes by Dual Photoredox and Copper Catalysis Wu, Y.-L.;Jiang, M.; Rao, L.; Cheng, Y.; Xiao, W.-J. and Chen, J.-R.* Org. Lett., 2022, 24, 7470-7475. DOI: 10.1021/acs.orglett.2c03124 Construction of axial chirality via asymmetric radical trapping by cobalt under visible light Jiang, X.; Xiong, W.; Deng, S.; Lu, F.-D.; Jia, Y.; Yang, Q.; Xue, L.-Y.; Qi, X.-T.; Tunge, J. A.; Lu, L.-Q.* and Xiao, W.-J.* Nat., Catal. 2022, 5, 788-797. DOI: 10.1038/s41929-022-00831-1 Copper-Catalyzed Three-Component Photo-ATRA-Type Reaction for Asymmetric Intermolecular C–O Coupling Wang, P.-Z.; Liang, Y.-J.; Wu, X.; Guan, W.*; Xiao, W.-J.* and Chen, J.-R.* ACS Catal. 2022, 12, 10925–10937. DOI: 10.1021/acscatal.2c03576 Photoinduced C–O bond cleavage for copper-catalyzed allenyl radical cyanation Lu, F.-D.; Shu, Z.-C.; He, G.-F.; Bai, J.-C.; Lu, L.-Q.* and Xiao, W.-J.* Org. Chem. Front., 2022, 9, 5259-5263. DOI: 10.1039/D2QO00938B Switchable Radical Carbonylation by Philicity Regulation Lu, B.; Xu, M.-H.; Qi, X.-T.; Jiang, M.; Xiao, W.-J.* and Chen, J.-R.* J. Am. Chem. Soc. 2022, 144, 14923–14935. DOI: 10.1021/jacs.2c06677 N-Heterocyclic Carbene (NHC)-Catalyzed Desymmetrization of Biaryldialdehydes to Construct Axially Chiral Aldehydes Zhao, W.; Liu, J.; He, X.-K.; Jiang, H.; Lu, L.-Q.* and Xiao, W.-J.* Chinese Journal of Organic Chemistry, 2022, 42,2504-2514. DOI: 10.6023/cjoc202203048 High-order dipolar annulations with metal-containing reactive dipoles Zhang, M.-M.;† Qu, B.-L.;† Shi, B.;† Xiao, W.-J. and Lu, L.-Q.* Chem. Soc. Rev. 2022, 51, 4146-4174. DOI: 10.1039/D1CS00897H Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides Jiang, X.; Jiang, H.; Yang, Q.; Cheng, Y.; Lu, L.-Q.*; J. A. Tunge and Xiao, W.-J.* J. Am. Chem. Soc. 2022, 144, 8347-8354. DOI: 10.1021/jacs.2c02481 Synthesis of Chiral Endocyclic Allenes by Palladium-Catalyzed Asymmetric Annulation Followed by Cope Rearrangement Shi, B.; Liu, J.-B.; Wang, Z.-T.; Wang, L.; Lan, Y.; Lu, L.-Q.* and Xiao, W.-J. Angew. Chem. Int. Ed. 2022, 61, e202117215. DOI: 10.1002/anie.202117215 Catalytic Asymmetric Construction of Axially and Centrally Chiral Heterobiaryls by Minisci Reaction Liang, D.; Chen, J.-R.; Tan, L.-P.; He, Z.-W. and Xiao, W.-J.* nJ. Am. Chem. Soc. 2022, 144, 6040-6049. DOI: 10.1021/jacs.2c01116 Photoredox-Catalyzed and Copper(II) Salt-Assisted Radical Addition/Hydroxylation Reaction of Alkenes, Sulfur Ylides, and Water Dong-Mei Yan, Shuang-Hua Xu, Hao Qian, Pan-Pan Gao, Ming-Hang Bi, Wen-Jing Xiao*, and Jia-Rong Chen*DOI: 10.1021/acscatal.2c00638 Photoredox-Enabled Chromium-Catalyzed Alkene Diacylations Jing Liu,# Liang-Qiu Lu,# Yi-Xin Luo, Wei Zhao, Peng-Chao Sun, Wei-Wei Jin, Xiao-Tian Qi,* Ying Cheng,* and Wen-Jing Xiao*DOI: 10.1021/acscatal.1c05672