Krebs, Carsten - The Pennsylvania State University

个人简介

10/1989 - 9/1991 Undergraduate studies in Chemistry at the Ruhr-Universität Bochum, Germany 10/1991 - 9/1993 Graduate studies in Chemistry at the Ruhr-Universität Bochum, Germany 10/1993 - 5/1994 Diploma thesis in the Department of Inorganic Chemistry I at the RuhrUniversität Bochum, Germany Title: 'Synthesis of sulfur- and selenium functionalized macrocyclic ligands and their coordination chemistry' Supervisor: Professor K. Wieghardt 6/1994 - 2/1997 Ph.D. thesis at the Max Planck Institut für Strahlenchemie, Mülheim/Ruhr,Germany Title: 'Magnetic exchange interactions in linear tetranuclear transition metal compounds', Supervisor: Professor K. Wieghardt 2/1997 - 1/2002 Postdoctoral Fellow, Physics Department, Emory University, Atlanta, GA,Supervisor: Professor B. H. Huynh Awards 9/1991 cum laude for Undergraduate Studies 5/1994 summa cum laude for Graduate Studies and Diploma Thesis 2/1997 summa cum laude for Ph.D. Thesis 2005 - 2008 “Beckman Young Investigator” of the Beckman Foundation 2006 – 2011 “Camille Dreyfus Teacher Scholar” of the Dreyfus Foundation 2008 “Pfizer Award in Enzyme Chemistry” of the ACS Biochemistry Division 2012 “Early Career Award” of the Society of Biological Inorganic Chemistry (SBIC)

研究领域

Spectroscopic and Kinetic Studies on the Mechanisms of Iron-containing Enzymes

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang B, Arcinas AJ, Radle MI, Silakov A, Booker SJ, Krebs C. The First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]0-like Auxiliary Cluster. Journal of the American Chemical Society. PMID 31899624 DOI: 10.1021/jacs.9b11093 0.68 Zhou S, Pan J, Davis KM, Schaperdoth I, Wang B, Boal AK, Krebs C, Bollinger JM. Steric enforcement of cis-epoxide formation in the radical C-O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces Fosfomycin. Journal of the American Chemical Society. PMID 31769979 DOI: 10.1021/jacs.9b10974 0.68 Cutsail GE, Blaesi EJ, Pollock CJ, Bollinger JM, Krebs C, DeBeer S. High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates. Journal of Inorganic Biochemistry. 203: 110877. PMID 31710865 DOI: 10.1016/j.jinorgbio.2019.110877 0.68 Dong HT, Speelman AL, Kozemchak CE, Sil D, Krebs C, Lehnert N. The Fe₂(NO)₂ Diamond Core: A Unique Structural Motif in Non-Heme Iron-NO Chemistry. Angewandte Chemie (International Ed. in English). PMID 31550416 DOI: 10.1002/anie.201911968 0.48 Davis KM, Altmyer M, Martinie RJ, Schaperdoth I, Krebs C, Bollinger JM, Boal AK. Structure of a ferryl mimic in the archetypal iron(II)- and 2-(oxo)-glutarate-dependent dioxygenase, TauD. Biochemistry. PMID 31503454 DOI: 10.1021/acs.biochem.9b00598 0.68 Zhang B, Rajakovich LJ, Van Cura D, Blaesi EJ, Mitchell AJ, Tysoe CR, Zhu X, Streit BR, Rui Z, Zhang W, Boal AK, Krebs C, Bollinger JM. Substrate-triggered Formation of a Peroxo-Fe(III/III) Intermediate during Fatty Acid Decarboxylation by UndA. Journal of the American Chemical Society. PMID 31487162 DOI: 10.1021/jacs.9b06093 0.68 Pan J, Wenger ES, Matthews ML, Pollock CJ, Bhardwaj M, Kim AJ, Allen BD, Grossman RB, Krebs C, Bollinger JM. Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases. Journal of the American Chemical Society. PMID 31475820 DOI: 10.1021/jacs.9b06689 0.68 Gumkowski JD, Martinie RJ, Corrigan P, Pan J, Bauerle MR, Almarei M, Booker SJ, Silakov A, Krebs C, Boal AK. Analysis of RNA methylation by phylogenetically diverse Cfr radical SAM enzymes reveals an iron-binding accessory domain in a clostridial enzyme. Biochemistry. PMID 31246421 DOI: 10.1021/acs.biochem.9b00197 0.68 Chekan JR, Ongpipattanakul C, Wright TR, Zhang B, Bollinger JM, Rajakovich LJ, Krebs C, Cicchillo RM, Nair SK. Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants. Proceedings of the National Academy of Sciences of the United States of America. PMID 31209034 DOI: 10.1073/pnas.1900711116 0.68 Dunham NP, Del Río Pantoja JM, Zhang B, Rajakovich LJ, Allen BD, Krebs C, Boal AK, Bollinger JM. Hydrogen Donation but not Abstraction by a Tyrosine (Y68) During Endoperoxide Installation by Verruculogen Synthase (FtmOx1). Journal of the American Chemical Society. PMID 31117657 DOI: 10.1021/jacs.9b03567 0.68 Rajakovich L, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM. A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases. Biochemistry. PMID 30789718 DOI: 10.1021/acs.biochem.9b00044 0.68 McQuarters AB, Blaesi EJ, Kampf JW, Alp EE, Zhao J, Hu M, Krebs C, Lehnert N. Synthetic Model Complex of the Key Intermediate in Cytochrome P450 Nitric Oxide Reductase. Inorganic Chemistry. PMID 30623648 DOI: 10.1021/acs.inorgchem.8b02947 0.6 Dunham NP, Mitchell AJ, Del Río Pantoja JM, Krebs C, Bollinger JM, Boal AK. α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC. Biochemistry. PMID 30403469 DOI: 10.1021/acs.biochem.8b00901 0.68 Blaesi EJ, Palowitch GM, Hu K, Kim AJ, Rose HR, Alapati R, Lougee MG, Kim HJ, Taguchi AT, Tan KO, Laremore TN, Griffin RG, Krebs C, Matthews ML, Silakov A, et al. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224458 DOI: 10.1073/pnas.1811993115 0.68 Dong H, White CJ, Zhang B, Krebs C, Lehnert N. Non-Heme Diiron Model Complexes Can Mediate Direct NO Reduction: Mechanistic Insight Into Flavodiiron NO Reductases. Journal of the American Chemical Society. PMID 30220202 DOI: 10.1021/jacs.8b08567 0.52 Grell TAJ, Kincannon WM, Bruender NA, Blaesi EJ, Krebs C, Bandarian V, Drennan CL. Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase. The Journal of Biological Chemistry. PMID 30217813 DOI: 10.1074/jbc.RA118.005369 0.36 Speelman AL, White CJ, Zhang B, Alp EE, Zhao J, Hu M, Krebs C, Penner-Hahn J, Lehnert N. Non-Heme High-Spin {FeNO} Complexes: One Ligand Platform Can Do It All. Journal of the American Chemical Society. PMID 30107126 DOI: 10.1021/jacs.8b06095 0.52 Martinie RJ, Blaesi EJ, Bollinger JM, Krebs C, Finkelstein KD, Pollock C. Two-Color Valence-to-Core X-ray Emission Spectroscopy Tracks Cofactor Protonation State in a Class I Ribonucleotide Reductase. Angewandte Chemie (International Ed. in English). PMID 30075052 DOI: 10.1002/anie.201807366 0.68 Wang B, Blaszczyk AJ, Knox H, Zhou S, Blaesi EJ, Krebs C, Wang R, Booker SJ. Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from Streptomyces fradiae, a Cobalamin-Dependent Radical S-Adenosylmethionine Methylase. Biochemistry. PMID 30036047 DOI: 10.1021/acs.biochem.8b00693 0.6 Prakash D, Walters KA, Martinie RJ, McCarver AC, Kumar AK, Lessner DJ, Krebs C, Golbeck JH, Ferry JG. Towards a mechanistic and physiological understanding of a ferredoxin disulfide reductase from the domains and . The Journal of Biological Chemistry. PMID 29720404 DOI: 10.1074/jbc.RA118.002473