Wang, Lai-Xi - University of Maryland - Department of Chemistry & Biochemistry

个人简介

Ph.D., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 1991 Postdoctoral Fellow, Johns Hopkins University, 1994 Postdoctoral Research Associate, Massachusetts Institute of Technology, 1997

研究领域

Bioorganic Chemistry; Synthetic Carbohydrate Chemistry; Glycobiology; Enzymology; Molecular Biology; Immunology

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang, L.X., Amin, M.N., "Chemical and chemoenzymatic synthesis of glycoproteins for deciphering functions" (Invited Review), Chemistry & Biology, 21, 51-66 (2014). Ahmed, A.A, Giddens, J.P., Pincetic, A., Lomino, J.V., Ravetch, J.V., Wang, L.X., Bjorkman, P.J., "Structural characterization of anti-inflammatory Immunoglobulin G Fc proteins", J. Mol. Biol., 426, 3166-79 (2014). Trastoy, B., Lomino, J.V., Pierce, B.G., Carter, L.G., Gunther, S., Giddens, J.P., Snyder, G.A., Weiss, T.M., Weng, Z., Wang, L.X., Sundberg, E.J., "Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies", Proc. Natl. Acad. Sci. USA, 111, 6714-6719 (2014). Smith, E.L., Giddens, J.P., Iavarone, A.T., Godula, K., Wang, L.X., Bertozzi, C.R., "Chemoenzymatic Fc glycosylation via engineered aldehyde tags", Bioconjugate Chem., 25, 788-795 (2014). Chiang, M.J., Holbert, M.A., Kalin, J.H., Ahn, Y.H., Giddens, J, Amin, M.N., Taylor, M.S., Collins, S.L., Chan-Li, Y, Waickman, A, Hsiao, P.Y., Bolduc, D, Leahy, D.J., Horton, M.R., Wang, L.X., Powell, J.D., Cole, P.A. , "An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. J. Am. Chem. Soc., 136, 3370-3373 (2014). Wang, L.X., "Synthetic carbohydrate antigens for HIV vaccine design" (Invited Review), Current Opinion in Chemical Biology, 17, 997–1005 (2013). Wang, L.X., Davis, B.G., "Realizing the promise of chemical glycobiology" (Invited Review), Chemical Science, 4, 3381-3394 (2013). Amin, M.N., McLellan, J.S., Huang, W., Orwenyo, J., Burton, D.R., Koff, W.C., Kwong, P.D., Wang, L.X., "Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies", Nature Chem. Biol., 9, 521-526 (2013). Pancera, M., Shahzad-ul-Hussan, S., Doria-Rose, N. A., McLellan, J.S., Dai, K., Loesgen, S., Staupe, S.P., Yang, Y., Haynes, B. F., Amin, M.N., Wang, L. X., Burton, D. R., Koff, W.C., Nabel, G.J., Mascola, J.R., Bewley, C.A., Kwong, P.D., "Structural basis for diverse N-glycan recognition and enhanced HIV-1 neutralization by V1/V2-directed antibodies", Nature Struct. Mol. Biol., 20, 804-813 (2013). Orwenyo, J., Huang, W., Wang, L.X., "Chemoenzymatic synthesis and lectin recognition of a selectively fluorinated glycoprotein", Bioorg. Med. Chem., 21, 4768-77 (2013). Lomino, J.V., Naegeli, A., Orwenyo, J., Amin, M.N., Aebi, M., Wang, L.X., "A two-step enzymatic glycosylation of polypeptides with complex N-glycans", Bioorg. Med. Chem., 21, 2262-70 (2013). Wang, H., Huang, W., Orwenyo, J., Banerjee, A., Vasta, G.R., Wang, L.X., "Design and synthesis of glycoprotein-based multivalent glyco-ligands for influenza hemagglutinin and human galectin-3". Bioorg. Med. Chem., 21, 2037-44 (2013). Feng, C., Ghosh, A., Amin, M.N., Giomarelli, B., Shridhar, S., Banerjee, A., Fernández-Robledo, J.A., Bianchet, M.A., Wang, L.X., Wilson, I.B., Vasta, G.R., "The galectin CvGal1 from the eastern oyster (Crassostrea virginica) binds to blood group A oligosaccharides on the hemocyte surface", J. Biol. Chem., 288, 24394-409 (2013). Huang, W., Giddens, J., Fan, S.Q., Toonstra, C., Wang, L.X., "Chemoenzymatic glycoengineering of intact IgG antibodies for gain of functions", J. Am. Chem. Soc., 134, 12308−12318 (2012). Cross, A.S., Hyun, S.W., Miranda-Ribera, A., Feng, C., Liu, A., Nguyen, C., Zhang, L., Luzina, I.G., Atamas, S.P., Twaddell, W.S., Guang, W., Lillehoj, E.P., Puche, A.C., Huang, W., Wang, L.X., Passaniti, A., Goldblum, S.E. "NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia. NEU1 restrains endothelial cell migration whereas NEU3 does not", J. Biol. Chem., 287, 15966-15980 (2012). Fan, S., Huang, W., Wang, L. X. "Remarkable transglycosylation activity of glycosynthase mutants of Endo-D, an endo-β-N-acetylglucosaminidase from Streptococcus pneumoniae", J. Biol. Chem., 287, 11272–11281 (2012). Lillehoj, E.P., Hyun, S.W., Feng, C., Zhang, L., Liu, A., Guang, W., Nguyen, C., Luzina, I.G., Atamas, S.P., Passaniti, A., Twaddell, W.S., Puché, A.C., Wang, L.X., Cross, A.S., Goldblum, S.E. "NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling", J. Biol. Chem., 287, 8214-8231 (2012). Wang, L. X., Lomino, J. V. "Emerging technologies for making glycan-defined glycoproteins" (Invited Review), ACS Chemical Biology, 7, 110-122 (2011). McLellan, J., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K., O’Dell, S., Patel, N., Shahzad-ul-Hussan, S., Yang, Y., Zhang, B., Zhou, T., Zhu, J., Boyington, J. C., Chuang, G. Y., Diwanji, D., Georgiev, I., Kwon, Y. D., Lee, D., Louder, M. K., Moquin, S., Schmidt, S. D., Yang, Z. Y., Bonsignori, M., Crump, J. A., Kapiga, S. H., Sam, N. E., Haynes, B. F., Burton, D. R., Koff, W. C., Walker, L. M., Phogat, S., Wyatt, R., Orwenyo, J., Wang, L. X., Arthos, J., Bewley, C. A., Mascola, J. R., Nabel, G. J., Schief, W. R., Ward, A. B., Wilson, I. A., Kwong, P. D., "Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9", Nature, 480, 336-343 (2011). Zou, G., Ochiai, H., Huang, W., Yang, Q., Li, C., Wang, L. X., "Chemoenzymatic synthesis and Fc receptor binding of homogeneous glycoforms of antibody Fc domain. Presence of a bisecting sugar moiety enhances the affinity of Fc to FcIIIa receptor", J. Am. Chem. Soc., 133, 18975-18991 (2011).