Thirumalai, Devarajan - University of Maryland - Department of Chemistry & Biochemistry

个人简介

B. S. Indian Institute of Technology Kanpur 1977 Ph. D. University of Minnesota, 1982, (Advisor: Prof D. G. Truhlar) Post Doctoral Fellow, Columbia University 1982-1985 (Advisor: Prof. B. J. Berne)

研究领域

Research in Dr. Thirumalai’s group focuses on various problems in equilibrium and non equilibrium statistical mechanics. Currently various aspects of the transition from liquid to amorphous state are being investigated. Another area of research involves the theoretical study of polymer-colloid interactions. Research is also being carried out to understand the dynamics of protein folding.

近期论文

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H. Kang, P.A. Pincus, C. Hyeon, and D. Thirumalai, "Effects of Macromolecular Crowding on the Collapse of Biopolymers", Phys. Rev. Lett. 114, 068303 (2015) J.C. Lin, J. Yoon, C. Hyeon, and D. Thirumalai, "Using Simulations and Kinetic Network Models to Reveal the Dynamics and Functions of Riboswitches", Methods in Enzymology 553, 235 (2015) S. Vaitheeswaran, and D. Thirumalai, "Entropy and enthalpy of interaction between amino acid side chains in nanopores", J. Chem. Phys. 141, 22D523 (2014) M. Hinczewski, and D. Thirumalai, "Cellular Signaling Networks Function as Generalized Wiener-Kolmogorov Filters to Suppress Noise", Phys. Rev. X. 4, 041017 (2014) D. Thirumalai, "Universal relations in the self-assembly of proteins and RNA", Phys. Biol. 11, 053005 (2014) B. Ramm, J. Stigler, M. Hinczewski, D. Thirumalai, H. Herrmann, G. Woehlke, and M. Rief, "Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments", Proc. Natl. Acad. Sci. U.S.A. 111, 11359 (2014) C. Hyeon, N.A. Denesyuk, and D. Thirumalai, "Development and Applications of Coarse-Grained Models for RNA", Isr. J. Chem. 54, 1358 (2014) J. Yoon, J.C. Lin, and D. Thirumalai, "Dynamical Transition and Heterogeneous Hydration Dynamics in RNA", J. Phys. Chem. B. 118, 7910 (2014) P.I. Zhuravlev, G. Reddy, J.E. Straub, and D. Thirumalai, "Propensity to Form Amyloid Fibrils Is Encoded as Excitations in the Free Energy Landscape of Monomeric Proteins", J. Mol. Biol. 426, 2653 (2014) L. Dominguez, L. Foster, S.C. Meredith, J.E. Straub, and D. Thirumalai, "Structural Heterogeneity in Transmembrane Amyloid Precursor Protein Homodimer Is a Consequence of Environmental Selection", J. Am. Chem. Soc. 136, 9619 (2014) S. Chakrabarti, M. Hinczewski, and D. Thirumalai, "Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes", Proc. Natl. Acad. Sci. 111, 9048 (2014) J.C. Lin, C. Hyeon, and D. Thirumalai, "Sequence-dependent folding landscapes of adenine riboswitch apatamers", Phys. Chem. Chem. Phys 16, 63766 (2014) C. Hyeon, M. Hinczewski, and D. Thirumalai, "Evidence of disorder in biological molecules from single molecule pulling experiments", Phys. Rev. Lett. 112, 138101 (2014) J.E. Straub and D. Thirumalai, "Membrane-protein interactions are key to understanding amyloid formation", J. Phys. Chem. Lett. 5, 633 (2014) L. Domiinguez, S.C. Meredith, J.E. Straub, and D. Thirumalai, "Transmembrane fragment structures of amyloid precursor protein depend on membrane surface curvature", J. Am. Chem. Soc. 136, 854 (2014) E.J. Denning, D. Thirumalai, A.D. MacKerell Jr., "Protonation of trimethylamine N-oxide (TMAO) is required for stabilization of RNA tertiary structure", Biophys. Chem. 184, 8 (2013) J.C. Lin and D. Thirumalai, "Kinetics of Allosteric Transitions in S-adenosymethionine Riboswitch are Accurately predicted from the folding landscape", J. Am. Chem. Soc. 135, 16641 (2013) C. Hyeon and D. Thirumalai, "Generalized iterative annealing model for the action of RNA chaperones", J. Chem. Phys. 139, 121924 (2013) H. Kang, T.R. Kirkpatrick and D. Thirumalai, "Manifestation of random first-order transition theory in Wigner Glasses", Phys. Rev. E 88, 042308 (2013) D.L. Pincus and D. Thirumalai, "Force-Induced Unzipping Transitions in an Athermal Crowded Environment", J. Phys. Chem. B 117, 13107 (2013) M. Hinzewski, R. Tehver and D. Thirumalai, "Design principles governing the motility of myosin V", Proc. Natl. Acad. Sci. 110, E4059 (2013) M. Gruebele and D. Thirumalai, "Perspective: Reaches of chemical physics in biology", J. Chem. Phys. 139, 121701 (2013)