Orban, John - University of Maryland - Department of Chemistry & Biochemistry

个人简介

Ph.D. Chemistry, Australian National University,1985. CSIRO Postdoctoral Fellow, 1985-1987.

研究领域

My research interests are focused in the area of protein structural biology and design, particularly in understanding how the malleability of protein folds relates to biological function. High field solution NMR spectroscopy and other biophysical and biochemical methods are employed in my laboratory.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

2013 Bryan, P. N., and J. Orban. 2013. "Implications of protein fold switching.". Curr Opin Struct Biol 23(2):314-6. 2012 He, Y. et al. 2012. "Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.". Proteins 80(12):2810-7. He, Y., Y. Chen, P. A. Alexander, P. N. Bryan, and J. Orban. 2012. "Mutational tipping points for switching protein folds and functions.". Structure 20(2):283-91. Chen, Y. et al. 2011. "A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans.". BMC Genomics 12 Suppl 1:S7. Zeng, Y. et al. 2011. "The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.". J Biol Chem 286(16):13985-94. Bryan, P. N., and J. Orban. 2010. "Proteins that switch folds.". Curr Opin Struct Biol 20(4):482-8. Shen, Y. et al. 2010. "De novo structure generation using chemical shifts for proteins with high-sequence identity but different folds.". Protein Sci 19(2):349-56. Alexander, P. A., Y. He, Y. Chen, J. Orban, and P. N. Bryan. 2009. "A minimal sequence code for switching protein structure and function.". Proc Natl Acad Sci U S A 106(50):21149-54. He, Y., Y. Chen, P. Alexander, P. N. Bryan, and J. Orban. 2008. "NMR structures of two designed proteins with high sequence identity but different fold and function.". Proc Natl Acad Sci U S A 105(38):14412-7. Sari, N., K. E. Fisher, P. N. Bryan, and J. Orban. 2007. "Main chain NMR assignments of subtilisin Sbt70 in its prodomain-bound state.". Biomol NMR Assign 1(2):209-11.