个人简介
1986-1993在南京大学化学系获得化学学士和硕士学位
2001年担任南京大学生命科学学院生物化学系副教授
2003年在南京大学生命科学学院获得生物化学与分子生物学博士学位
2004-2007在美国弗吉尼亚大学医学院做访问研究
2011年至今担任南京大学生命科学学院教授
获奖情况
2013年南京大学北京银行“京”英奖教金
2011年南京大学优秀教学成果奖一等奖
2008年教育部双语教学示范课程奖
2002江苏省普通高校优秀课程群奖
2001江苏省高等教育教学成果一等奖
研究领域
炎症性肠病以及炎症相关性疾病的研究
结肠炎-癌转化分子机制研究以及肿瘤分子靶向治疗
近期论文
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Huang, Z.; Ma J.; Chen M.; Jiang H.; Fu Y.; Gan J.; Dong L.; Zhang, J.; Chen, J. Dual TNF-α/IL-12p40 interference as a strategy to protect against colitis based on miR-16 precursors with macrophage targeting vectors (2015). Molecular Therapy doi: 10.1038/mt.2015.111.
Sun, D., C. Wang, S. Long, Y. Ma, Y. Guo, Z. Huang, X. Chen, C. Zhang, J. Chen and J. Zhang (2015). C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer. Br J Cancer 112(9): 1491-1500.
Zhang P, He Z, Wang C, Chen J, Zhao J, Zhu X, Li C, Min Q, Zhu J (2015). In Situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release. ACS Nano 9(1):789-98
Diao, W., F. Jin, B. Wang, C. Y. Zhang, J. Chen, K. Zen and L. Li (2014). The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury. Protein Cell 5(9): 714-724.
Huang, Z., T. Shi, Q. Zhou, S. Shi, R. Zhao, H. Shi, L. Dong, C. Zhang, K. Zeng, J. Chen and J. Zhang (2013). miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12 β during murine colitis and human Crohn's disease. Gut 63(8):1247-57.
Sun, D., F. Yu, Y. Ma, R. Zhao, X. Chen, J. Zhu, C. Y. Zhang, J. Chen and J. Zhang (2013). MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). J Biol Chem 288(13): 9508-9518.
Zhang, Z., Y. Zha, W. Hu, Z. Huang, Z. Gao, Y. Zang, J. Chen, L. Dong and J. Zhang (2013). The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development. J Biol Chem 288(52): 37082-37093.
Huang, Z., L. Dong, J. Chen, F. Gao, Z. Zhang, J. Chen and J. Zhang (2012). Low-molecular weight chitosan/vascular endothelial growth factor short hairpin RNA for the treatment of hepatocellular carcinoma. Life Sci 91(23-24): 1207-1215.
Chen, J., H. Chen, P. Li, H. Diao, S. Zhu, L. Dong, R. Wang, T. Guo, J. Zhao and J. Zhang (2011). Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 32(21): 4793-4805.
Cheng, X., F. Gao, J. Xiang, X. Jiang, J. Chen and J. Zhang (2011). Galactosylated α,β-poly[(2-hydroxyethyl)-L-aspartamide]-bound doxorubicin: improved antitumor activity against hepatocellular carcinoma with reduced hepatotoxicity. Anticancer Drugs 22(2): 136-147.
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