6. Yuhui Sheng, Yi Fu, Zhi Zhou*. Enzymatic Enantioselective Protonation Regulated by an Artificial Enzyme Harboring an In Situ-Biosynthesized S-(3-Aminophenyl)-cysteine.
Organic Letters 2025, 5c03837.
https://pubs.acs.org/doi/10.1021/acs.orglett.5c03837
5. Wei Huang†, Shiping Wang†, Ya Wei, Yuting Bai, Zhixi Zhu, Dejing Yin, Tao Liu, Xiang Sheng*, Zhi Zhou*. Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid.
Nature Communications 2025, 16, 8698. (†equal contribution)
Open Access: https://www.nature.com/articles/s41467-025-63733-3
4. Qinru Hu, Liangyu Feng, Ran You, Zhixi Zhu, Jie Lei, Zhi Zhou*. Design and Evolution of an Artificial Aldolase with an Abiological Catalytic Cofactor in Apo-Myoglobin.
Organic Letters 2025, 27, 10417.
https://pubs.acs.org/doi/10.1021/acs.orglett.5c03309
3. Zhixi Zhu, Zhi Zhou*. Artificial Enzyme Design with Novel Functions via Site-Specific Chemical Modification.
ChemBioChem 2025, e202500075.
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202500075
2. Yuting Bai†, Yuhui Sheng†, Yi Fu, Zhi Zhou*, Jing Wu*. Enzymatic Synthesis of Saturated Bioisosteres of Ortho-Substituted Benzenes by Artificial Photoenzyme.
Chem. Eur. J. 2025, e202404519. (†equal contribution)
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202404519
1. Zhixi Zhu, Qinru Hu, Yi Fu, Yingjia Tong, Zhi Zhou*. Design and Evolution of an Enzyme for the Asymmetric Michael Addition of Cyclic Ketones to Nitroolefins by Enamine Catalysis.
Angew. Chem. Int. Ed., 2024, e202404312.
https://onlinelibrary.wiley.com/doi/10.1002/anie.202404312
Before Jiangnan University:
8. Linda Atta†, Zhi Zhou†, Gerard Roelfes*. In vivo Biocatalytic Cascades Featuring an Artificial-Enzyme-Catalyzed New-to-Nature Reaction
Angew. Chem. Int. Ed., 2023, e202214191. (†equal contribution)
https://onlinelibrary.wiley.com/doi/10.1002/anie.202214191
7. Zhi Zhou*, Gerard Roelfes*. Synergistic Catalysis of Tandem Michael Addition/Enantioselective Protonation Reactions by an Artificial Enzyme
ACS Catalysis, 2021, 11, 9366.
Open Access https://pubs.acs.org/doi/10.1021/acscatal.1c02298
6. Zhi Zhou, Gerard Roelfes*. Synergistic catalysis in an artificial enzyme by simultaneous action of two abiological catalytic sites
Nature Catalysis, 2020, 3, 289. https://www.nature.com/articles/s41929-019-0420-6
News & Views by Nature Catalysis: https://www.nature.com/articles/s41929-020-0435-z
(文章中文解读请见国内学术平台X-MOL头条报道：https://www.x-mol.com/news/158962)
5. Zhi Zhou, Zhouxiang Wang, Qin Ouyang*, Wei Du, Ying-Chun Chen*. Switchable regioselectivity in amine-catalysed asymmetric cycloadditions.
Nature Chemistry, 2017, 9, 590.
https://www.nature.com/articles/nchem.2698
Highlight by Synfacts.
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1590093
(文章中文解读请见国内学术平台X-MOL头条报道：https://www.x-mol.com/news/4762)
4. Zhi Zhou,† Q. He,† Y. Jiang, W. Du, Y.-C. Chen*. Double Thiol-Chiral Brønsted Base Catalysis: Asymmetric Cross Rauhut–Currier Reaction and Sequential [4 + 2] Annulation for Assembly of Different Activated Olefins.
Organic Letters, 2019, 21, 7184. (†equal contribution)
https://pubs.acs.org/doi/10.1021/acs.orglett.9b02944
3. Zhi Zhou, Z. X. Wang, Q. Ouyang, W. Xiao, W. Du, Y.-C. Chen*. Cross-conjugated trienamine catalysis with alkylidene cyclic enones: application in regioselective aza-Diels Alder reaction.
Chemistry - A European Journal, 2017, 23, 2945.
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201605606
2. Zhi Zhou, X. Feng, Y.-C. Chen*. Direct remote asymmetric bisvinylogous 1,4-additions of cyclic 2,5-dienones to nitroalkenes.
Organic Letters, 2014, 16, 2370.
https://pubs.acs.org/doi/10.1021/ol500700d
1. X. Feng,† Z. Zhou,† C. Ma, X. Yin, L. Dong, Y.-C. Chen*. Trienamines Derived from Interrupted Cyclic 2,5-Dienones: Remote C=C Bond Activation for Asymmetric Inverse-Electron-Demand Aza-Diels Alder Reaction.
Angew. Chem. Int. Ed., 2013, 52, 14173. (§equal contribution)
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201307460
参与作者代表性文章：
3. R. Leveson-Gower, Z. Zhou, I. Drienovská, G. Roelfes*. Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel-Crafts Alkylase.
ACS Catalysis, 2021, 11, 6763.
Open Access https://pubs.acs.org/doi/10.1021/acscatal.1c00996
2. L. Villarino*, S. Chordia, L. Alonso-Cotchico, E. Reddem, Z. Zhou, A. M. T. Thunnissen, J.-D. Maréchal, G. Roelfes*. Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme.
ACS Catalysis, 2020, 10, 11783.
https://pubs.acs.org/doi/10.1021/acscatal.0c01619
1. X. Feng, Z. Zhou, R. Zhou, Q.-Q. Zhou, L. Dong, Y.-C. Chen*.“Stereodivergence in Amine-Catalyzed Regioselective [4 + 2] Cycloadditions of β-Substituted Cyclic Enones and Polyconjugated Malononitriles.”
J. Am. Chem. Soc., 2012,134, 19942.
https://pubs.acs.org/doi/10.1021/ja3106219
