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成果及论文

在研科研项目:

(1)深圳理工大学新引进人才科研启动经费。 

(2)科技部,脱细胞基质来源的可注射光热响应性水凝胶微球用于软骨再生的研究,在研,主持。

(3)浙江省科技厅,电刺激下血管模拟肽梯度修饰的取向神经导管调控施旺细胞促进周围神经再生,在研,主持。


论文:

1. You Zhifeng*, Li L*, Li H* et al. MXene‐Based Photothermal‐Responsive Injectable Hydrogel Microsphere Modulates Physicochemical Microenvironment to Alleviate Osteoarthritis. Smart Medicine, 2025, 4(2): e70006.

2. You Zhifeng#, Gao X#, Kang X, et al. Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair. Bioactive Materials, 2023, 29: 36-49. (#: co-first author)

3. Liu L#, You Zhifeng#, et al. Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis. Nature Materials, 2017, 16(12): 1252-1261.

4. Gao X, You Zhifeng, Li Y, et al. Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair. Acta biomaterialia, 2023, 155: 235-246.

5. Xiong T, Yang K, Zhao T, Zhao H, Gao X, You Zhifeng, et al. Multifunctional integrated nanozymes facilitate spinal cord regeneration by remodeling the extrinsic neural environment. Advanced Science, 2023, 10(7): 2205997.

6. Sun X, Xiong T, Yang K, Wang L, Yang W, Zhao H, Gao X, You Zhifeng, et al. Individually Tailored Modular “Egg” Hydrogels Capable of Spatiotemporally Controlled Drug Release for Spinal Cord Injury Repair. Advanced Healthcare Materials, 2023, 12(27): 2301169.

7. Shen H, Fan C, You Zhifeng, et al. Advances in biomaterial‐based spinal cord injury repair. Advanced Functional Materials, 2022, 32(13): 2110628.

8. Shen H, Xu B, Yang C, Xue W, You Zhifeng, et al. A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury. Biomaterials, 2022, 280: 121279.

9. Zhao Y#, You Zhifeng#, Xing D, et al. Comparison of chondrocytes in knee osteoarthritis and regulation by scaffold pore size and stiffness. Tissue Engineering Part A, 2021, 27(3-4): 223-236.

10. Liu L, Yu H, Long Y, You Zhifeng, et al. Asporin inhibits collagen matrix‐mediated intercellular mechanocommunications between fibroblasts during keloid progression. The FASEB Journal, 2021, 35(7): e21705.

11. Yu H#, You Zhifeng#, Yan X, et al. TGase‐Enhanced Microtissue Assembly in 3D‐Printed‐Template‐Scaffold (3D‐MAPS) for Large Tissue Defect Reparation. Advanced Healthcare Materials, 2020, 9(18): 2000531.

12. Xing D, Liu W, Li J J, Liu L, Guo A, Wang B, Hu H, Zhao Y, Chen Y, You Zhifeng, et al. Engineering 3D functional tissue constructs using self-assembling cell-laden microniches. Acta biomaterialia, 2020, 114: 170-182.

13. Liu L, Yu H, Zhao H, Wu Z, Long Y, Zhang J, Yan X, You Zhifeng, et al. Matrix-transmitted paratensile signaling enables myofibroblast–fibroblast cross talk in fibrosis expansion. Proceedings of the National Academy of Sciences, 2020, 117(20): 10832-10838.

14. You Zhifeng#, Zhou L#, Li W, et al. Mechanical microenvironment as a key cellular regulator in the liver. Acta Mechanica Sinica, 2019, 35: 289-298.

15. Huang C, Liu L, You Zhifeng, et al. Managing keloid scars: From radiation therapy to actual and potential drug deliveries. International wound journal, 2019, 16(3): 852-859.

16. Qi C, Li Y, Badger P, Yu H, You Zhifeng, et al. Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase. Biomaterials, 2017, 126: 1-9.

17. Li Y, Yan X, Liu W, Zhou L, You Zhifeng, et al. 3D microtissues for injectable regenerative therapy and high-throughput drug screening. Journal of visualized experiments: JoVE, 2017 (128).

18. Huang C, Liu L, You Zhifeng, et al. Keloid progression: a stiffness gap hypothesis. International wound journal, 2017, 14(5): 764-771.

19. Huang C, Liu L, You Zhifeng, et al. Endothelial dysfunction and mechanobiology in pathological cutaneous scarring: lessons learned from soft tissue fibrosis .  British Journal of Dermatology, 2017, 177(5): 1248-1255.