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成果及论文

2025

1. Lingxiao Zhang*, Jie Bai, Aining Shen, Jing Zhao, Zhenwei Su, Maoze Wang, Mingdong Dong*, Zhi Ping Xu*, Artificially Tagging Tumors with Nano-Aluminum Adjuvant-Tethered Antigen mRNA Recruits and Activates Antigen-Specific Cytotoxic T Cells for Enhanced Cancer Immunotherapy, Biomaterials, 2025, 123085. https://www.sciencedirect.com/science/article/pii/S0142961225000043


2. Jiaxi Yong, Wang Xu, Miaomiao Wu, Run Zhang, Christopher WG Mann, Guoquan Liu, Christopher A Brosnan, Neena Mitter, Bernard J Carroll*, Zhi Ping Xu*, Lysozyme-coated nanoparticles for active uptake and delivery of synthetic RNA and plasmid-encoded genes in plants, Nature Plants, 2025, 1-14. https://www.nature.com/articles/s41477-024-01882-x


3. Ying Li, Chao He, Ai Ning Shen, Yu Wang, Zhi Ping Xu, Lingxiao Zhang* and Ran Wang*, The pH of microenvironment directly modulates the phenotype and function of cancer-associated fibroblasts, ACS Omega, 2025, In Press. 


2024

1. Chong Gao, Jianping Jiang*, Jing Zhao, Zhi Ping Xu*, Lingxiao Zhang*, Engineered nano-aluminum adjuvant for cancer immunotherapy: Progress, challenges and opportunities towards preclinical/clinical application, Coordination Chemistry Reviews, 2024, 519: 216109. https://www.sciencedirect.com/science/article/pii/S0010854524004557


2. Zhenwei Su, Hamza Boucetta, Jiahui Shao, Jinling Huang, Ran Wang, Aining Shen, Wei He*, Zhi Ping Xu*, Lingxiao Zhang*, Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs, Acta Pharmaceutica Sinica B, 2024, 14: 4665-4682. (Invited Review) https://www.sciencedirect.com/science/article/pii/S2211383524003745


3. Qipeng Jia, Qunfeng Li, Hamza Boucetta, Zhi Ping Xu*, Lingxiao Zhang*, Biomimetic-smart materials for osteochondral regeneration and repair, Microstructures, 2024, 4: 2024026. (Invited Review) https://www.oaepublish.com/articles/microstructures.2023.84


4. Lingxiao Zhang*, Chaojie Zhu, Jing Zhao, Luca Scimeca, Mingdong Dong, Ruitian Liu*, Yingbo Jia*, Zhi Ping Xu*, Recent Advances in Nanomodulators for Augmenting Cancer Immunotherapy in Cold Tumors: Insights from Drug Delivery to Drug‐Free Strategies, Advanced Functional Materials, 2024, 34: 2311914. (Invited Review) https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202311914


5. Gábor Varga*, Thanh-Truc Nguyen, Jing Wang, Dihua Tian, Run Zhang, Li Li, Zhi Ping Xu*, Isomorphic Insertion of Ce (III)/Ce (IV) Centers into Layered Double Hydroxide as a Heterogeneous Multifunctional Catalyst for Efficient Meerwein–Ponndorf–Verley Reduction, ACS Applied Materials & Interfaces, 2024, 16: 11453-11466. https://pubs.acs.org/doi/full/10.1021/acsami.3c16732


5. Astha Sharma, Jiachen Yan, Prakrit Siwakoti, Ayad Saeed, Vipul Agarwal, Zhi Ping Xu, Ran Wang*, Tushar Kumeria*, Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death, Nano TransMed, 2024, 3: 100053. https://www.sciencedirect.com/science/article/pii/S2790676024000244


2023

1. Chaojie Zhu, Jianping Jiang, Yingbo Jia, Zhi Ping Xu*, Lingxiao Zhang*, Beyond drug delivery system: immunomodulatory layered double hydroxide nanoadjuvants take an essential step forward in cancer immunotherapy, Accounts of Materials Research, 2023, 4: 758-771. (Invited Review) https://pubs.acs.org/doi/full/10.1021/accountsmr.3c00094


2. Lingxiao Zhang*, Shengjie Hou, Fatemeh Movahedi, Zijin Li, Li Li, Jing Hu, Yingbo Jia, Yaru Huang, Jie Zhu, Xiaoying Sun, Linghui Zeng*, Ruitian Liu*, Zhi Ping Xu*, Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore memory and recognition of Alzheimer’s disease mice, Nano Today, 2023, 49: 101788. https://www.sciencedirect.com/science/article/abs/pii/S1748013223000373


3. Yingbo Jia, Jing Hu, Chaojie Zhu, Zijing Li, Xinyu Yang, Ruitian Liu, Linghui Zeng*, Lingxiao Zhang*, Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy, Journal of Controlled Release, 2023, 354: 770-783. https://www.sciencedirect.com/science/article/abs/pii/S0168365923000524


4. Xiao-mei Yang, Xuan-dong Lin, Wei Shi, Shen-xia Xie, Xia-ning Huang, Shi-hua Yin, Xiao-bing Jiang, Bruce D Hammock, Zhi Ping Xu*, Xiao-ling Lu*, Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy, Signal Transduction and Targeted Therapy, 2023, 8: 328. https://www.nature.com/articles/s41392-023-01523-3


2022

1. Lingxiao Zhang*, Yingbo Jia, Jinju Yang, Lun Zhang, Shengjie Hou, Xiaoyun Niu, Jie Zhu, Yaru Huang, Xiaoying Sun, Zhi Ping Xu*, Ruitian Liu*, Efficient immunotherapy of drug-free layered double hydroxide nanoparticles via neutralizing excess acid and blocking tumor cell autophagy, ACS Nano, 2022, ACS Nano 2022, 16: 12036–12048. https://pubs.acs.org/doi/abs/10.1021/acsnano.2c02183