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研究方向

To realize a strategic use of modern inert bond activation in bioactive natural product synthesis would greatly increase the overall efficiency in total synthesis. Our group main research will be placing on building a bridge between methodologies involving/but not limited to transition-metal-catalysis and total synthesis. Our synthesis philosphy is to use TM-catalyzed inert bond (C-X bond, X=C, O, N etc.) activation to construct skeletons while leaving the functional group decoration to C-H bond activation methodology in the late stage of synthesis. Base on these guidelines, our group research will be devoted to the following areas:

(1) Developing new type of rearrangement strategies that is directed towards highly efficient synthesis of fused- and bridged-ring frameworks;

(2) Applying  the aforementioned  methodology as strategical key step for core skeleton assembly in complex natural product synthesis;

(3) Evaluation  of  synthesized  bioactive  molecules/samples  for  medicinal  development and probing its metabolic regulation ability towards oncogenesis;