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成果及论文

(†共同第一作者,*通讯作者)文章列表

2022

Ketoreductases catalyzed (dynamic) kinetic resolution for biomanufacturing of chiral chemicals

Chenming Huang, Junling Liu, Jiali Fang, Xian Jia, Zhendong Zheng*, Song You*, Bin Qin*, 

Frontiers in Bioengineering and Biotechnology 2022, 10, 929784. 10.3389/fbioe.2022.929784

Enzymes and Chemo-Enzymes Catalyzed Stereodivergent Synthesis

Jiaxiang Lv, Yaqi Ding, Chenming Huang, Lingling Guo, Jiali Fang, Xian Jia, Wenhe Zhang,* Song You*, Bin Qin*, 

Pharmaceutical Fronts 2022, accepted.


Efficient Synthesis of Apremilast Precursor and Chiral β-Hydroxy Sulfones via Ketoreductase-Catalyzed Asymmetric Reduction

Jiyang Guo, Xiao Gao, Dong Qian, Huibin Wang, Xian Jia, Wenhe Zhang*Bin Qin*, Song You*

Organic & Biomolecular Chemistry 2022, 20, 2081-2085. 10.1039/D1OB02485J


Amorphous zirconium metal-organic frameworks assembled from mixed porphyrins as solvent-free catalysts for Knoevenagel condensation

Weiguo Zuo, Shunbin Yang, Yajie Xing, Xiwen Xiao, Duona Fan, Hengyu Li, Guanqun Wang, Bin Qin, Song You*, Xian Jia* 

Dalton Transactions 2022, 51, 6631-6637. 10.1039/D2DT00142J




2021

Engineering of Saccharomyces pastorianus Old Yellow Enzyme 1 for the Synthesis of Pharmacologically Active (S)-Profen Derivatives

Guigao Liu, Shang Li, Qinghua Shi, Hengyu Li, Jiyang Guo, Jingping Ouyang, Xian Jia, Lihan Zhang*, Song You*, Bin Qin*

Molecular Catalysis 2021, 507, 111568. 10.1016/j.mcat.2021.111568


Development of an enzymatic process for the synthesis of the key intermediate of telotristat ethyl

Hengyu Li, Wenhe Zhang, Xianyan Jiang, Huibin Wang, Qi Wang, Jiajun Wang, Xian Jia, Bin Qin*, Song You*

Advanced Synthesis & Catalysis 2021, 363 (2), 540-548. 10.1002/adsc.202001110


Identification of Four Ene Reductases and Their Preliminary Exploration in the Asymmetric Synthesis of (R)-Dihydrocarvone and (R)-Profen Derivatives

Qinghua Shi, Yutian Jia, Huibin Wang, Shang Li, Hengyu Li, Jiyang Guo, Tong Dou, Bin Qin*, Song You*

Enzyme and Microbial Technology 2021, 150, 109880. 10.1016/j.enzmictec.2021.109880

Both-In-One Hybrid Bacteria Suppress the Tumor Metastasis and Relapse via Tandem-Amplifying Reactive Oxygen Species-Immunity Responses

Mengchi Sun, Hao Ye, Qinghua Shi, Jun Xie, Xiang Yu, Hao Ling, Song You, Zhonggui He, Bin Qin*, Jin Sun*

Advanced Healthcare Materials 2021, 2100950. 10.1002/adhm.202100950


2020

Old yellow enzymes: structures and structure-guided engineering for stereocomplementary bioreduction

Qinghua Shi, Huibin Wang, Junling Liu, Shang Li, Jiyang Guo, Hengyu Li, Xian Jia, Hua Huo, Zhendong Zheng, Song You*, Bin Qin*

Applied Microbiology and Biotechnology 2020, 104 (19), 8155-8170. 10.1007/s00253-020-10845-z 


Engineering of Saccharomyces pastorianus Old Yellow Enzyme 1 for the Synthesis of Pharmacologically Active (S)-Profen Derivatives

Guigao Liu, Shang Li, Qinghua Shi, Hengyu Li, Jiyang Guo, Jingping Ouyang, Xian Jia, Lihan Zhang, Song You*, Bin Qin*

ChemRxiv 2020. 10.26434/chemrxiv.12894056.v1


2019

Key sites insight on the stereoselectivity of four mined aldo-keto reductases toward α-keto esters and halogen-substituted acetophenones

Wenhe Zhang, Tianhui Zhu, Hengyu Li, Fengyu Qin, Feiting Zhang, Rui Zhang, Xian Jia, Bin Qin*, Song You*

Applied Microbiology and Biotechnology 2019, 103 (15), 6119-6128. 10.1007/s00253-019-09932-7


2018

Discovery of a switch between Prelog and Anti-Prelog reduction toward halogen-substituted acetophenones in short-chain dehydrogenase/reductases

Fengyu Qin†, Bin Qin*,†, Wenhe Zhang, Yalin Liu, Xin Su, Tianhui Zhu, Jingping Ouyang, Jiyang Guo, Yuxin Li, Feiting Zhang, Jun Tang, Xian Jia*, Song You*

ACS Catalysis 2018, 8 (7), 6012-6020. 10.1021/acscatal.8b00807


Stereodivergent synthesis of carveol and dihydrocarveol through ketoreductases/ene‐reductases catalysed asymmetric reduction

Jiyang Guo, Rui Zhang, Jingping Ouyang, Feiting Zhang, Fengyu Qin, Guigao Liu, Wenhe Zhang, Hengyu Li, Xiaohong Ji, Xian Jia, Bin Qin*, Song You* 

ChemCatChem 2018, 10 (23), 5496-5504. 10.1002/cctc.201801391


Selective oxidations of cyperenoic acid by slightly reshaping the binding pocket of cytochrome P450 BM3

Yuxin Li†, Bin Qin†, Xiaoqin Li, Jun Tang, Yu Chen, Lina Zhou*, Song You*

ChemCatChem 2018, 10 (3), 559-565. 10.1002/cctc.201701088


2017

Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides. 

Lihan Zhang, Takuya Hashimoto, Bin Qin, Junko Hashimoto, Ikuko Kozone, Teppei Kawahara, Masahiro Okada, Takayoshi Awakawa, Takuya Ito, Yoshinori Asakawa, Masashi Ueki, Shunji Takahashi, Hiroyuki Osada, Toshiyuki Wakimoto, Haruo Ikeda*, Kazuo Shin-ya*, Ikuro Abe*

Angewandte Chemie International Edition 2017, 56 (7), 1740-1745. 10.1002/anie.201611371


Enantioselective bioreduction of benzo-fused cyclic ketones with engineered Candida glabrata ketoreductase 1–a promising synthetic route to ladostigil (TV3326)

Jingping Ou-yang, Wenhe Zhang, Fengyu Qin, Weiguo Zuo, Shaoyu Xu, Yan Wang, Bin Qin, Song You*, Xian Jia*

Organic & Biomolecular Chemistry 2017, 15(35), 7374-7379. 10.1039/c7ob01803g


2016

An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping

Bin Qin†, Yudai Matsuda†, Takahiro Mori, Masahiro Okada, Zhiyang Quan, Takaaki Mitsuhashi, Toshiyuki Wakimoto, Ikuro Abe*

Angewandte Chemie International Edition 2016, 55 (5), 1658-1661. 10.1002/anie.201509263


Engineering of Candida glabrata ketoreductase 1 for asymmetric reduction of α-halo ketones

Fengyu Qin†, Bin Qin†, Takahiro Mori, Yan Wang, Lingxin Meng, Xin Zhang, Xian Jia, Ikuro Abe, Song You*

ACS Catalysis 2016, 6 (9), 6135-6140. 10.1021/acscatal.6b01552


Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis

Masahiro Okada, Yudai Matsuda, Takaaki Mitsuhashi, Shotaro Hoshino, Takahiro Mori, Kazuya Nakagawa, Zhiyang Quan, Bin Qin, Huiping Zhang, Fumiaki Hayashi, Hiroshi Kawaide, Ikuro Abe*

Journal of the American Chemical Society 2016, 138 (31), 10011-10018. 10.1021/jacs.6b05799


2013-2015

“Mirror-Image” manipulation of curdione stereoisomer scaffolds by chemical and biological approaches: development of a sesquiterpenoid library

Bin Qin, Yuxin Li, Lingxin Meng, Jingping Ouyang, Danni Jin, Lei Wu, Xin Zhang, Xian Jia, Song You*

Journal of Natural Products 2015, 78 (2), 272-278. 10.1021/np500864e


Prelog and anti-Prelog stereoselectivity of two ketoreductases from Candida glabrata

Ping Liang†, Bin Qin†, Mao Mu, Xin Zhang, Xian Jia, Song You* 

Biotechnology Letters 2013, 35 (9), 1469-1473. 10.1007/s10529-013-1228-0


Directed evolution of Candida antarctica lipase B for kinetic resolution of profen esters

Bin Qin, Ping Liang, Xian Jia, Xin Zhang, Mao Mu, Xiaoying Wang, Guozhen Ma, Danni Jin, Song You*

Catalysis Communications 2013, 38, 1-5. 10.1016/j.catcom.2013.03.040