近5年部分论文列表
45. Jinyun Dong#, Yulong Li#, Hui Liang#, Zumei Wu#, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe-Sheng Chen, Fangfang Tao*, Xuelei Ma*, Jiang-Jiang Qin*. HSP70 Interactome-Mediated Proteolysis Targeting Chimera (HSP70-PROTAC) for Ferroptosis-Driven Cancer Treatment. Advanced Science 2025 DOI: 10.1002/advs.202513655
44. Shiqun Wang, Wenyan Yang, Ti Peng, Chunxiao Zhu, Jinyun Dong, Yichao Wang, Hu Yuan, Qingyan Sun, Xin Luan, Xiaoqing Guan*, Weidong Zhang*, Jiang-Jiang Qin*. IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer. Nature Communications. 2025 Nov 28;16(1):10733. doi: 10.1038/s41467-025-65762-4.
43. Jingxin Zhang#, Xiaoying Huang#, Lingchuan Ma#, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang-Jiang Qin, Xiang Wang, Yuhong Cao*, Kai Miao*. Micro-Organ Chip Deciphers Tumor-Derived G-CSF as Remote Commander of Lung Pre-Metastatic Niche via VEGFA-KDR Cascade. Advanced Science 2025 Nov 22:e18584. doi: 10.1002/advs.202518584.
42. Zhiyuan Jin#, Li Yuan#, Yubo Ma, Zu Ye, Zhao Zhang, Yi Wang, Can Hu, Jinyun Dong, Xinuo Zhang, Zhiyuan Xu, Yian Du, Xiaoqing Guan, Guangzhao Pan, Sichao Tian, Juan Li, Ruiwen Zhang, Jiang-Jiang Qin*, Xiangdong Cheng*. A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma: Identification of potential prognostic biomarkers and therapeutic targets. Genes Dis. 2025, 13(1):101717. doi: 10.1016/j.gendis.2025.101717.
41. Wenyan Yang, Wei Zhu, Zhiyang Yao, Zhao Wang, Shengzhi Liu, Xiaoqing Guan*, Jiang-Jiang Qin*. Morusin Suppresses Pancreatic Cancer Cell Proliferation and Migration by Targeting SLC6A12 to Inhibit NF-κB and β-catenin Signaling Pathways. Recent Pat Anticancer Drug Discov. 2025 Jun 23. doi: 10.2174/0115748928376279250613051117. Online ahead of print.
40. Qingyi Xiong#, Jinmei Jin#, Jiayi Lin, Bohan Zhang, Yixin Jiang, Zhe Sun, Lijun Zhang*, Ye Wu, Guozhi Zhao, Jiang-Jiang Qin*, Xin Luan*. The role of synthetic lethality in overcoming cancer therapy resistance: Emerging paradigm and recent advances. Drug Resistance Updates 2025, 83:101290. https://doi.org/10.1016/j.drup.2025.101290
39. Bo Zhu, Zheng Wu, Yiwen Shou, Kaili Zhao, Qinpei Lu, Jiang-Jiang Qin*, Hongwei Guo*. Harnessing the Power of Natural Products for Targeted Protein Degradation. Medicinal Research Reviews 2025, 45(5):1466-1514. https://onlinelibrary.wiley.com/doi/10.1002/med.22113
38. Guangqi Li#, Yuting Jiang#, Huan Tong#, Jifeng Liu#, Zedong Jiang, Yunuo Zhao, Keqin Tan, Yu Zhang, Xiaomeng Yin, Hong Yun, Yuxin He, Hu Liao*, Jiangjiang Qin*, Xuelei Ma*. Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer. Drug Resistance Updates 2025,79:101212. https://doi.org/10.1016/j.drup.2025.101212
37. Zumei Wu, Yulong Li, Jinyun Dong*, Jiang-Jiang Qin*. An updated review on the role of small molecules in mediating protein degradation. Eur J Med Chem 2025,287:117370. https://doi.org/10.1016/j.ejmech.2025.117370
36. Lingling Wang#, Guangzhao Pan#, Sichao Tian#, Che Zhang, Fangfang Tao*, Jiang-Jiang Qin*. Macranthoside B suppresses the growth of adenocarcinoma of esophagogastric junction by regulating iron homeostasis and ferroptosis through NRF2 inhibition. Current Cancer Drug Targets 2025 Jan 22. doi: 10.2174/0115680096370291250109103853. Online ahead of print.
35. Xiaofang Luo#, Ye Wu#, Xiaokun Zhang#, Min Tang, Feiye Ju, Zuodong Qin, Gregory J Duns, Wei-Dong Zhang*, Jiang-Jiang Qin*, Xin Luan*. Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters 2025,36(1): 109724. https://doi.org/10.1016/j.cclet.2024.109724
34. Jinyun Dong, Furong Ma, Maohua Cai, Fei Cao, Haobin Li, Hui Liang, Yulong Li, Guangyu Ding, Juan Li, Xiangdong Cheng*, Jiang-Jiang Qin*. Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis. J Med Chem 2024;67(18):16712-16736. doi: 10.1021/acs.jmedchem.4c01518.
33. Yichao Wang#, Guangyu Ding#, Chu Chu, Xiang-Dong Cheng*, Jiang-Jiang Qin*. Genomic biology and therapeutic strategies of liver metastasis from gastric cancer. Crit Rev Oncol Hematol 2024:202:104470. doi: 10.1016/j.critrevonc.2024.104470.
32. Jiahui Jiang, Yunhe Liu, Jiangjiang Qin, Jianfeng Chen, Jingjing Wu, Melissa P Pizzi, Rossana Lazcano, Kohei Yamashita, Zhiyuan Xu, Guangsheng Pei, Kyung Serk Cho, Yanshuo Chu, Ansam Sinjab, Fuduan Peng, Xinmiao Yan, Guangchun Han, Ruiping Wang, Enyu Dai, Yibo Dai, Bogdan A Czerniak, Andrew Futreal, Anirban Maitra, Alexander Lazar, Humam Kadara, Amir A Jazaeri, Xiangdong Cheng, Jaffer Ajani, Jianjun Gao, Jian Hu*, Linghua Wang*. METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics. Nat Commun 2024;15(1):7312. doi: 10.1038/s41467-024-51708-9.
31. Yanyang Liu#, Xuefei Yu#, Huize Shen, Yangjian Hong, Gaofeng Hu, Wenyuan Niu, Jiaming Ge, Jie Xuan, Jiang-Jiang Qin*, Qinglin Li*. Mechanisms of traditional Chinese medicine in the treatment and prevention of gastric cancer. Phytomedicine 2024:135:156003. doi: 10.1016/j.phymed.2024.156003.
30. Xiangdong Cheng#, Enyu Dai#, Jibo Wu#, Natasha M Flores, Yanshuo Chu, Ruiping Wang, Minghao Dang, Zhiyuan Xu, Guangchun Han, Yunhe Liu, Deyali Chatterjee, Can Hu, Jieer Ying, Yian Du, Litao Yang, Xiaoqing Guan, Shaowei Mo, Xuanye Cao, Guangsheng Pei, Jiahui Jiang, Xiaoyin Lu, Ana Morales Benitez, Rebecca E Waters, Melissa Pool Pizzi, Namita Shanbhag, Yibo Fan, Fuduan Peng, Samir M Hanash, George Calin, Andrew Futreal, Shumei Song, Cassian Yee, Pawel K Mazur*, Jiang-Jiang Qin*, Jaffer A Ajani*, Linghua Wang*. Atlas of metastatic gastric cancer links ferroptosis to disease progression and immunotherapy response. Gastroenterology. 2024;167(7):1345-1357. doi: 10.1053/j.gastro.2024.07.038.
29. Yulong Li, Jinyun Dong*, Jiang-Jiang Qin*. Small molecule inhibitors targeting heat shock protein 90: An updated review. Eur J Med Chem 2024; 275:116562. doi: 10.1016/j.ejmech.2024.116562.
28. Zhijie Xu#, Haiyan Zhou#, Tongfei Li#, Qiaoli Yi, Abhimanyu Thakur, Kui Zhang, Xuelei Ma*, Jiang-Jiang Qin*, Yuanliang Yan*. Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance. Drug Resist Updat 2024, 75: 101098. doi: 10.1016/j.drup.2024.101098.
27. Furong Ma#, Yulong Li#, Maohua Cai, Wenyan Yang, Zumei Wu, Jinyun Dong*, Jiang-Jiang Qin*. ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. Eur J Med Chem 2024, 270: 116387. https://doi.org/10.1016/j.ejmech.2024.116387
26. Xiaoqing Guan#, Yichao Wang#, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang-Dong Cheng*, Weidong Zhangg*, Jiang-Jiang Qin*. Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase. Advanced Science 2024; 11(18):e2307899. DOI: 10.1002/advs.202307899
25. Xinchen Lu#, Jinmei Jin#, Ye Wu#, Xiaoxia Liu, Xiaohui Liang, Jiayi Lin, Qingyan Sun, Jiangjiang Qin*, Weidong Zhang*, Xin Luan*. Progress in RAS-targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras. Med Res Rev 2024; 44(2):812-832. doi: 10.1002/med.21993.
24. Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu*, Jiang-Jiang Qin*, Yuanliang Yan*. Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy. Biomark Res 2024; 12(1):2. doi: 10.1186/s40364-023-00551-z.
23. Che Zhang#, Guangzhao Pan#, Jiang-Jiang Qin*. Role of F-box proteins in human upper gastrointestinal tumors. Biochim Biophys Acta Rev Cancer 2024; 1879(1):189035. doi: 10.1016/j.bbcan.2023.189035.
22. Huize Shen#, Rui Zhu#, Yanyang Liu, Yangjian Hong, Jiaming Ge, Jie Xuan, Wenyuan Niu, Xuefei Yu*, Jiang-Jiang Qin*, Qinglin Li*. Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance. Drug Resist Updat 2024; 72:101013. doi: 10.1016/j.drup.2023.101013.
21. Jiahan Le, Guangzhao Pan, Che Zhang, Yitao Chen*, Amit K Tiwari*, Jiang-Jiang Qin*. Targeting ferroptosis in gastric cancer: Strategies and opportunities. Immunol Rev 2024; 321(1):228-245. doi: 10.1111/imr.13280.
20. Wenyan Yang#, Shiqun Wang#, Shengqiang Tong, Wei-Dong Zhang*, Jiang-Jiang Qin*. Expanding the ubiquitin code in pancreatic cancer. Biochim Biophys Acta Mol Basis Dis. 2024; 1870(1):166884. doi: 10.1016/j.bbadis.2023.166884.
19. Fei Cao, Chu Chu, Jiang-Jiang Qin*, Xiaoqing Guan*. Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones. Chinese Medicine. 2023; 18(1):164. doi: 10.1186/s13020-023-00870-1.
18. Ruiping Wang#, Shumei Song#, Jiangjiang Qin#, Katsuhiro Yoshimura, Fuduan Peng, Yanshuo Chu, Yuan Li, Yibo Fan, Jiankang Jin, Minghao Dang, Enyu Dai, Guangsheng Pei, Guangchun Han, Dapeng Hao, Yating Li, Deyali Chatterjee, Kazuto Harada, Melissa Pool Pizzi, Ailing W Scott, Ghia Tatlonghari, Xinmiao Yan, Zhiyuan Xu, Can Hu, Shaowei Mo, Namita Shanbhag, Yang Lu, Matheus Sewastjanow-Silva, Ahmed Adel Fouad Abdelhakeem, Guang Peng, Samir M Hanash, George A Calin, Cassian Yee, Pawel Mazur, Autumn N Marsden, Andrew Futreal, Zhenning Wang, Xiangdong Cheng, Jaffer A Ajani*, Linghua Wang*. Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression. Cancer Cell. 2023; 41(8):1407-1426.e9. doi: 10.1016/j.ccell.2023.06.005.
17. Jinyun Dong*, Li Yuan, Can Hu, Xiangdong Cheng*, Jiang-Jiang Qin*. Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): An updated review. Pharmacol Ther. 2023; 249:108488. doi: 10.1016/j.pharmthera.2023.108488.
16. Yanshuo Chu, Enyu Dai, Yating Li, Guangchun Han, Guangsheng Pei, Davis R Ingram, Krupa Thakkar, Jiang-Jiang Qin, Minghao Dang, Xiuning Le, Can Hu, Qing Deng, Ansam Sinjab, Pravesh Gupta, Ruiping Wang, Dapeng Hao, Fuduan Peng, Xinmiao Yan, Yunhe Liu, Shumei Song, Shaojun Zhang, John V Heymach, Alexandre Reuben, Yasir Y Elamin, Melissa P Pizzi, Yang Lu, Rossana Lazcano, Jian Hu, Mingyao Li, Michael Curran, Andrew Futreal, Anirban Maitra, Amir A Jazaeri, Jaffer A Ajani, Charles Swanton, Xiang-Dong Cheng, Hussein A Abbas, Maura Gillison, Krishna Bhat, Alexander J Lazar, Michael Green, Kevin Litchfield, Humam Kadara, Cassian Yee, Linghua Wang*. Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance. Nature Medicine 2023;29(6):1550-1562. doi: 10.1038/s41591-023-02371-y.
15. Xiaoqing Guan#, Jing Yang#, Weiyi Wang#*, Bing Zhao, Shiyu Hu, Dehua Yu, Li Yuan, Yunfu Shi, Jingli Xu, Jinyun Dong, Jinxin Wang, Xiang-Dong Cheng*, Jiang-Jiang Qin*. Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer. Pharmacological Research 2023; 189:106703 https://doi.org/10.1016/j.phrs.2023.106703
14. Shengli Li#, Li Yuan#, Zhi-Yuan Xu, Jing-Li Xu, Gui-Ping Chen, Xiaoqing Guan, Guang-Zhao Pan, Can Hu, Jinyun Dong, Yi-An Du, Li-Tao Yang, Mao-Wei Ni, Rui-Bin Jiang, Xiu Zhu, Hang Lv, Han-Dong Xu, Sheng-Jie Zhang, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Integrative proteomic characterization of adenocarcinoma of esophagogastric junction. Nature Communications 2023; 14:778. https://doi.org/10.1038/s41467-023-36462-8
13. Chunxiao Zhu#, Xiaoqing Guan#, Xinuo Zhang#, Xin Luan, Zhengbo Song, Xiang-Dong Cheng*, Weidong Zhang*, Jiang-Jiang Qin*. Targeting KRAS mutant cancers: From druggable therapy to drug resistance. Molecular Cancer 2022;21:159. https://doi.org/10.1186/s12943-022-01629-2
12. Jing Yang#, Lingling Wang#, Xiaoqing Guan*, Jiang-Jiang Qin*. Inhibiting STAT3 signaling pathway by natural products for cancer prevention and therapy: In vitro and in vivo activity and mechanisms of action. Pharmacological Research 2022; 182: 106357. https://doi.org/10.1016/j.phrs.2022.106357
11. Jinyun Dong, Jing Yang, Wenkai Yu, Haobin Li, Maohua Cai, Jing-Li Xu, Han-Dong Xu, Yun-Fu Shi, Xiaoqing Guan*, Xiangdong Cheng*, Jiang-Jiang Qin*. Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3). J Enzyme Inhib Med Chem 2022; 37(1):2002-2016. doi: 10.1080/14756366.2022.2100366
10. Simin Qi#, Xiaoqing Guan#, Jia Zhang#, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng*, Weidong Zhang*, Jiang-Jiang Qin*. Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis. Molecular Cancer 2022; 21:70. https://doi.org/10.1186/s12943-022-01538-4
9. Haobin Li#, Jinyun Dong#,*, Maohua Cai, Zhiyuan Xu, Xiang-Dong Cheng*, Jiang-Jiang Qin*. Protein degradation technology: A strategic paradigm shift in drug discovery. J Hematol Oncol 2021; 14:138. DOI: 10.1186/s13045-021-01146-7.
8. Jinyun Dong, Xiang-Dong Cheng, Wei-Dong Zhang, Jiang-Jiang Qin*. Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation. J Med Chem 2021; 64(13): 8884-8915. DOI: 10.1021/acs.jmedchem.1c00629.
7. Libin Song#, Simin Qi#, Wei Hu#, Zhixiao Fang#, Dehua Yu, Teng Liu, Jingni Wu, Yangjun Wu, Aiwei Wu, Lanyun Feng, Jing Xie, Bo Zhang, Wenguang He, Zhouyu Ning, Luming Liu*, Jiang-Jiang Qin*, Shengli Li*. Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer. Mol Ther Nucleic Acids 2021; 26:11-21. DOI: 10.1016/j.omtn.2021.06.015.
6. Li Yuan#, Shao-Wei Mo#, Zhi-Yuan Xu#, Hang Lv, Jing-Li Xu, Kai-Bo Guo, Can Hu, Xiao-Feng Wang, Gui-Ping Chen, Jiang-Jiang Qin*, Xiang-Dong Cheng*. p-MEK Expression Predicts Prognosis of Patients with Adenocarcinoma of Esophagogastric Junction (AEG) and Plays a Role in Anti-AEG Efficacy of Huaier. Pharmacol Res 2021;165: 105411. DOI: 10.1016/j.phrs.2020.105411.
5. Jinyun Dong#, Zuodong Qin#, Wei-Dong Zhang, Gang Cheng, Assaraf G Yehuda, Charles R Ashby Jr, Zhe-Sheng Chen*, Xiang-Dong Cheng*, Jiang-Jiang Qin*. Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update. Drug Resist Updat 2020; 49:100681. DOI: 10.1016/j.drup.2020.100681. (ESI 1%高被引用论文)
4. Li Yuan#, Zhi-Yuan Xu#, Shan-Ming Ruan, Shaowei Mo, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Long non-coding RNAs towards precision medicine in gastric cancer: Early diagnosis, treatment, and drug resistance. Mol Cancer 2020; 19:96. DOI: 10.1186/s12943-020-01219-0.
3. Yuan Zhou, Runzhe Chen, Xiaofang Luo, Wei-Dong Zhang*, Jiang-Jiang Qin*. UbcH5c: An emerging target in cancer and immune disorders. Drug Discov Today 2020; 25(11):1988-1997. DOI: 10.1016/j.drudis.2020.09.015
2. Weiyi Wang#,*, Jing Yang#, Yan-Yan Liao, Gang Cheng, Jing Chen, Xiang-Dong Cheng*, Jiang-Jiang Qin*, Zongze Shao*. Cytotoxic nitrogenated azaphilones from the deep-sea derived fungus Chaetomium globosum MP4-S01-7. J Nat Prod 2020; 83(4):1157-1166. DOI: 10.1021/acs.jnatprod.9b01165.
1. Weiyi Wang#,*, Jing Yang#, Yan-Yan Liao, Gang Cheng, Jing Chen, Shaowei Mo, Li Yuan, Xiang-Dong Cheng*, Jiang-Jiang Qin*, Zongze Shao*. Aspeterreurone A, a cytotoxic benzodifuranone from a deep sea derived fungus Aspergillus terreus CC-S06-18. J Nat Prod 2020; 83(6):1998-2003. DOI: 10.1021/acs.jnatprod.0c00189.