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1.  Rational drug design and development based on Natural products

2.  The total synthesis and structural modification of natural product

3.  The biotransmation and biomimic study on natural product

4.  The application of t heoretical calculation in the study of natural product


 Rational drug design and development based on Natural products

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The synthesis of tacrine rhein hybrids 
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The multifunctional profile of tacrine rhein hybrids 
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  Eur J Med Chem 2013, 71C, 36-45.



The total synthesis and structural modification of natural product



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Org. Lett.201921 (6), 1841–1844

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Tetrahedron Letters 2013,54, 1405-1408
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The biotransmation and biomimic study on natural product

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Bioorganic & Medicinal Chemistry 2014, 22, 762-771



The application of theoretical calculation in the study of natural product

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J Agr Food Chem 2013, 61, 1501-1508.
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Org Lett 2011, 13, 3380-3383