Mass spectrometry (MS) research is an international frontier research direction. In the history of mass spectrometry, thirteen Nobel Prizes have been awarded for research related to its birth, development, and applications. Mass spectrometry has become an indispensable analytical tool in various basic and applied science fields such as chemistry, life science, biomedicine, pharmaceutical R&D, disease diagnosis and treatment. Our group is mainly engaged in the development and application of mass spectrometric methods and instrumentations, with particular emphasis on the development of innovative analytical strategies to solve key problems in biomedicine, medicinal chemistry, chemical biology and other frontier cross-science research areas. Relying on the Institute for Advanced Studies of Wuhan University, the group has been developing analytical techniques and applications in chemistry, biology, medicine, big data science and other disciplines with the interdisciplinary intersection of mass spectrometry research. It has been equipped with several high-end mass spectrometers required for research, including the Orbitrap high-resolution mass spectrometer (LTQ Velos Orbitrap Elite MS), linear ion trap mass spectrometer (LTQ XL MS), matrix-assisted laser desorption/ionization-time of flight mass spectrometer (MALDI-TOF/TOF MS), high-resolution ion mobility mass spectrometer (TIMS TOF Pro MS), etc., and independently developed photochemical reaction online mass spectrometry system, high-throughput chemical reaction mass spectrometry screening system and other equipment. In addition, we have also built well-equipped research platforms for synthetic chemistry and biochemistry, which can guarantte the high-level research. Our team members have interdisciplinary professional backgrounds in chemistry, biomedicine, bioinformatics, etc., and will conduct in-depth exploration in cutting-edge cross-science research fields. Our group has a long-term recruitment of postdoctoral fellows, exempt master's students, and PhD students under the application and assessment system, with training specialties in chemistry and biology. Our goal is to train students with zero foundation in mass spectrometry to become young experts in the field of mass spectrometry and interdisciplinary sciences, and we welcome students who are interested in our research to join us!
The main research directions include:
(1） Deep structure-resolved mass spectrometry analysis. From the novel dimensions of chemical reactivity, spatial conformational specificity, and chemical lifetime variability of molecules, we develop multi-dimensional mass spectrometry methods to realize structure-resolved mass spectrometry analysis of biology and chemistry in complex systems, so as to realize their conformational relationship and biological function studies.
(2) High-Throughput Chemical Reaction Screening And Prediction Based on Mass Spectrometry. Develop innovative mass spectrometric methods for chiral, cis-trans isomerization and other reaction types, and study high-throughput reaction screening and chemical big data acquisition methods to achieve rapid discovery and artificial intelligently prediction of new reactions.
(3) Mass Spectrometry-based Deep Omics And Big Data Analysis. Using chemoselective strategies, we develop analytical methods such as deep isomeromics and modified proteomics, and combine them with bioinformatics to reveal the deep molecular mechanisms in major diseases and important biological processes.