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成果及论文

24. G. Feng, M. Gao, H. Chen, Z. Zhang, J. Chen, Y. Tong, P. Wu, R. Fu, Y. Lin, S. Chen.* Stable-Isotope N-Me Aziridination Enables Accurate Quantitative C=C Isomeric Lipidomics. Anal. Chem. 2024, 96, 2524-2533. (BioRxiv 2022, https://doi.org/10.1101/2022.04.24.489320)

23. L. Shen, Z. Zhang, P. Wu, J. Yang, Y. Cai, K. Chen, S. Chai, J. Zhao, H. Chen, X. Dai, B. Yang, W. Wei, L. Dong, J. Chen, P. Jiang, C. Cao, C. Ma, C. Xu, Y. Zou, J. Zhang, W. Xiong, Z. Li, S. Xu, B. Shu, M. Wang, Z. Li, Q. Wan, N. Xiong,* S. Chen.* Mechanistic Insight into Glioma Through Spatially Multidimensional Proteomics. Sci. Adv. 2024, 10, eadk1721.

22. W. Nie, Q. Wan, J. Sun, M. Chen, M. Gao, S. Chen.* Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery. Nat. Commun. 2023, 14, 6671.

21. Y. Hao,# M. Chen,# X. Huang, H. Xu, P. Wu, S. Chen.* 4D-diaXLMS: Proteome-wide Four-Dimensional Data-Independent Acquisition Workflow for Cross-linking Mass Spectrometry. Anal. Chem. 2023, 95, 37, 14077–14085.

20. Q. Wan, K. Chen, X. Dong, X. Ruan, H. Yi,* S. Chen.* Elucidation of Underlying Reactivities of Alternating Current Electrosynthesis by Time-resolved Mapping of Short-lived Reactive Intermediates. Angew. Chem. Int. Ed. 2023, 62, e202306460. (ChemRxiv, 2022, DOI: 10.26434/chemrxiv-2022-p7mfd)

19. Q. Wan,# Y. Xiao,# G. Feng, X. Dong, W. Nie, M. Gao, Q. Meng,* S. Chen.* Visible-light-activated aziridination reaction enables simultaneous resolving of C=C bond location and the sn-position isomers in lipids. Chin. Chem. Lett. 2023, 108775.

18. P. Zhu, G. Bu, R. Hu, X. Ruan, R. Fu, Z. Zhang, Q. Wan, X. Liu, Y. Miao,* S. Chen.* Lipidomic Characterization of Oocytes at Single-Cell Level Using Nanoflow Chromatography-Trapped Ion Mobility Spectrometry-Mass Spectrometry. Molecules, 2023, 28, 4202. (Invited)

17. Y. Wei,# Z. Zhang,# Y. Zhang,# J. Li, X. Ruan, Q. Wan, T. Yin, Y. Zou*, S. Chen,* Y. Zhang.* Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality. MedComm, 2023, 4, e302.

16. M. Chen, P. Zhu, Q. Wan, X. Ruan, P. Wu, Y. Hao, Z. Zhang, J. Sun, W. Nie, S. Chen.* High-Coverage Four-Dimensional Data-Independent Acquisition Proteomics and Phosphoproteomics Enabled by Deep Learning-Driven Multidimensional Predictions. Anal. Chem. 2023, 95, 7495–7502. (BioRxiv, 2022, doi: https://doi.org/10.1101/2022.06.12.495786)

15. G. Feng, M. Gao, L. Wang, J. Chen, M. Hou, Q. Wan, Y. Lin, G. Xu, X. Qi, S. Chen.* Dual-resolving of positional and geometric isomers of C=C bonds via bifunctional photocycloaddition-photoisomerization reaction system. Nature Communications, 2022, 13, 2652.

14. T. Wang, Y. Hao, S. Chen.* Uncovering the interference from lipid fragments on the qualification and quantification of serum metabolites in matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis. Rapid Commun. Mass Spectrom. 2022, 36, e9293. (Invited)

13. M. Chen,#* Y. Hao,# S. Chen.* A protocol for investigating lipidomic dysregulation and discovering lipid biomarkers from human serums. STAR Protocols 2022, 3, 101125. (Invited)

12. L. Wu, Q. Wan,* W. Nie, Y. Hao, G. Feng, M. Chen, S. Chen.* High-Throughput Nano-Electrostatic-Spray Ionization/Photoreaction Mass Spectrometric Platform for the Discovery of Visible-Light-Activated Photocatalytic Reactions in Picomole-scale. Anal. Chem. 2021, 93, 14560–14567.

11. Q. Wan,# M. Chen,# Z. Zhang,# Y. Yuan,# H. Wang, Y. Hao, W. Nie, L. Wu and S. Chen.* Machine Learning of Serum Metabolic Patterns Encodes Asymptomatic SARS-CoV-2 Infection. Front. Chem. 2021, 9, 746134. (Invited)

10.Y. Hao,# Z. Zhang,# G. Feng,# M. Chen,# Q. Wan, J. Lin, L. Wu, W. Nie, and S. Chen.* Distinct lipid metabolic dysregulation in asymptomatic COVID-19. iScience 2021, 24, 102974.

9. G. Feng, Y. Hao, L Wu, S. Chen.* Visible-Light activated [2+2] cycloaddition reaction enables pinpointing carbon-carbon double bonds in lipids. Chem. Sci. 2020, 11, 7244-7251. (https://doi.org/10.26434/chemrxiv.11813475.v1) (Cited: 6)

Prior to joining WHU:

8. S. Chen, A. Datta-Chaudhuri, P. Deme, A. Dickens, R. Dastgheyb, P. Bhargava, H. Bi, N. J. Haughey.* Lipidomic characterization of extracellular vesicles in human serum. J. Circ. Biomark. 2019, 8, 1-12. (Cited: 57)

7. S. Khuder , S. Chen, S. Letendre , T. Marcotte, I. Grant, D. Franklin , L. Rubin, J. Margolick, L. Jacobson, N. Sacktor, G. D'Souza, V. Stosor, J. Lake, G. Rapocciolo, J. McArthur, A. Dickens, N. Haughey.* Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology, 2019, 92, e1344-e1353. (Cited: 13)

6. J. Xue, H. Liu, S. M. Chen,* C. Xiong,* L. Zhan, J. Sun, Z. Nie.* Mass spectrometry imaging of the in situ drug release from nanocarriers. Sci. Adv. 2018, aat9039. (Cited: 67)

5. Q. Wan, S. M. Chen, A. K. Badu-Tawiah*. Integrated mass spectrometry platform enables picomole-scale real-time electrosynthetic reaction screening and discovery. Chem. Sci. 2018, 9, 5724-5729. (Cited: 21)

4. S. M. Chen,# Q. Wan,# A. K. Badu-Tawiah.* Mass spectrometry for paper-based immunoassays: toward on-demand diagnosis. J. Am. Chem. Soc. 2016, 138, 6356–6359. (Highlighted by BBC, Fortune, Daily Mail (UK), etc., Cited: 114)

3. S. M. Chen,# Q. Wan,# A. K. Badu-Tawiah.* Picomole-scale real time photoreaction screening: discovery of visible-light promoted dehydrogenation of tetrahydroquinolines under ambient conditions. Angew. Chem. Int. Ed. 2016, 55, 9345-9349. (Cited: 89)

2. S. M. Chen, C. Xiong, H. Liu, Q. Wan, J. Hou, Q. He, A. Badu-Tawiah, and Z. X. Nie.* Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials. Nat. Nanotech. 2015, 10, 176-182. (Highlighted by Nature Nanotechnology: "More than a picture", Cited: 174)

1. Q. Wan,# S. M. Chen,# W. Shi, L. Li and H. M. Ma.* Lysosomal pH rise during heat shock monitored by a new lysosome-targeting near-infrared ratiometric fluorescent probe. Angew. Chem. Int. Ed. 2014, 126, 11096-11100. (ESI "Highly Cited Paper", Cited: 416)