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成果及论文

16. M. Chen, P. Zhu, P. Wu, Y. Hao, Z. Zhang, J. Sun, W. Nie, Suming Chen.* High-Coverage Four-Dimensional Data-Independent Acquisition Proteomics and Phosphoproteomics Enabled by Deep Learning-Driven Multi-Dimensional Prediction. BioRxiv, 2022, doi: https://doi.org/10.1101/2022.06.12.495786.

15. G. Feng, M. Gao, L. Wang, J. Chen, M. Hou, Q. Wan, Y. Lin, G. Xu, X. Qi, S. Chen.* Dual-resolving of positional and geometric isomers of C=C bonds via bifunctional photocycloaddition-photoisomerization reaction system. Nature Communications, 2022, 13, 2652.

14. T. Wang, Y. Hao, S. Chen.* Uncovering the interference from lipid fragments on the qualification and quantification of serum metabolites in matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis. Rapid Commun. Mass Spectrom. 2022, 36, e9293.

13. M. Chen,#* Y. Hao,# S. Chen.* A protocol for investigating lipidomic dysregulation and discovering lipid biomarkers from human serums. STAR Protocols 2022, 3, 101125.

12. L. Wu, Q. Wan,* W. Nie, Y. Hao, G. Feng, M. Chen, S. Chen.* High-Throughput Nano-Electrostatic-Spray Ionization/Photoreaction Mass Spectrometric Platform for the Discovery of Visible-Light-Activated Photocatalytic Reactions in Picomole-scale. Anal. Chem. 2021, 93, 14560–14567.

11. Q. Wan,# M. Chen,# Z. Zhang,# Y. Yuan,# H. Wang, Y. Hao, W. Nie, L. Wu and S. Chen*. Machine Learning of Serum Metabolic Patterns Encodes Asymptomatic SARS-CoV-2 Infection. Front. Chem. 2021, 9, 746134.

10.Y. Hao,# Z. Zhang,# G. Feng,# M. Chen,# Q. Wan, J. Lin, L. Wu, W. Nie, and S. Chen.* Distinct lipid metabolic dysregulation in asymptomatic COVID-19. iScience 2021, 24, 102974.

9. G. Feng, Y. Hao, L Wu, S. M. Chen.* Visible-Light activated [2+2] cycloaddition reaction enables pinpointing carbon-carbon double bonds in lipids. Chem. Sci. 2020, 11, 7244-7251. (https://doi.org/10.26434/chemrxiv.11813475.v1) (Cited: 6)

Prior to joining WHU:

8. S. Chen, A. Datta-Chaudhuri, P. Deme, A. Dickens, R. Dastgheyb, P. Bhargava, H. Bi, N. J. Haughey.* Lipidomic characterization of extracellular vesicles in human serum. J. Circ. Biomark. 2019, 8, 1-12. (Cited: 25)

7. S. Khuder , S. Chen, S. Letendre , T. Marcotte, I. Grant, D. Franklin , L. Rubin, J. Margolick, L. Jacobson, N. Sacktor, G. D'Souza, V. Stosor, J. Lake, G. Rapocciolo, J. McArthur, A. Dickens, N. Haughey.* Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology, 2019, 92, e1344-e1353. (Cited: 6)

6. J. Xue, H. Liu, S. M. Chen,* C. Xiong,* L. Zhan, J. Sun, Z. Nie.* Mass spectrometry imaging of the in situ drug release from nanocarriers. Sci. Adv. 2018, aat9039. (Cited: 39)

5. Q. Wan, S. M. Chen, A. K. Badu-Tawiah*. Integrated mass spectrometry platform enables picomole-scale real-time electrosynthetic reaction screening and discovery. Chem. Sci. 2018, 9, 5724-5729. (Cited: 11)

4. S. M. Chen,# Q. Wan,# A. K. Badu-Tawiah.* Mass spectrometry for paper-based immunoassays: toward on-demand diagnosis. J. Am. Chem. Soc. 2016, 138, 6356–6359. (Highlighted by BBC, Fortune, Daily Mail (UK), etc., Cited: 90)

3. S. M. Chen,# Q. Wan,# A. K. Badu-Tawiah.* Picomole-scale real time photoreaction screening: discovery of visible-light promoted dehydrogenation of tetrahydroquinolines under ambient conditions. Angew. Chem. Int. Ed. 2016, 55, 9345-9349. (Cited: 60)

2. S. M. Chen, C. Xiong, H. Liu, Q. Wan, J. Hou, Q. He, A. Badu-Tawiah, and Z. X. Nie.* Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials. Nat. Nanotech. 2015, 10, 176-182. (Highlighted by Nature Nanotechnology: "More than a picture", Cited: 136)

1. Q. Wan,# S. M. Chen,# W. Shi, L. Li and H. M. Ma.* Lysosomal pH rise during heat shock monitored by a new lysosome-targeting near-infrared ratiometric fluorescent probe. Angew. Chem. Int. Ed. 2014, 126, 11096-11100. (ESI "Highly Cited Paper", Cited: 351)