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成果及论文

近年主要论文（2017-）

  1. C. Wang, S. Hu, S. Wang, J.Du, Z. Zhao, Z. Zheng, H. Qiu, X. Ma, J. Li, H. Liu, M. Cao*, W. Gao*. Industrial-scale production of Lacto-N-tetraose in engineered Bacillus subtilis via modular pathway optimization, Metabolic Engineering, 2026, 93, 232-242
  2. S. Hu, S. Wang, Z. Zhao, Y. Wu, Z. Zheng, X. Ma, J. Li, M. Cao*, H. Liu*, W. Gao*. Metabolic engineering strategies for enhanced microbial synthesis of lacto-N-neotetraose: a key acetylated human milk oligosaccharide, Biotechnology Advances, 2025, 108794
  3. Z. Meng, D. Ma, N. He*, Y. Lu*, M. Cao*. Expanding the frontiers of microbial biosynthesis with synthetic microbial communities, Current Opinion in Biotechnology, 2025, 96, 103351 
  4. Y. Li, D. Xia*, Y. Xie, R. Dong, M. Cao*, Q. Li. Y. Wang*. Direct CO2 transformation to malate via bioelectrosynthesis upon engineered Shewanella oneidensis, Journal of the American Chemical Society, 2025, 147, 15397−15407
  5. Y. Chen, W. Xia, Z. Pan, F. Lu, Y. Liu, M. Cao*, N. He*. Development of a Cell-Free, Toehold Switch-Based Biosensor for Rapid and Sensitive Zika Virus Detection, Analytical Chemistry, 2025, 97, 3486−3494
  6. Y. Chen, W. Xia, F. Lu, Z. Chen, Y. Liu, M. Cao*, N. He*. Cell-Free Synthesis System: An Accessible Platform from Biosensing to Biomanufacturing,  Microbiological Research, 2025, 293, 128079
  7. L. Tian, T. Qi, F. Zhang, V. Tran, J. Yuan, Y. Wang, N. He*, M. Cao*. Synthetic biology approaches to improve tolerance of inhibitors in lignocellulosic hydrolysates, Biotechnology Advances, 2024, 78: 108477
  8. H. Chen, S. Jiang, K. Xu, Z. Ding, J. Wang, M. Cao*, J. Yuan*. Design of Thermoresponsive Genetic Controls with Minimal Heat-Shock Response, ACS Synthetic Biology, 2024, 13: 3032-3040
  9. Y. Li, M. Cao*, V. Gupta*, Y. Wang*. Metabolic engineering strategies to enable microbial electrosynthesis utilization of CO2: recent progress and challenges. Critical Reviews in Biotechnology, 2024, 44(3): 352-372
  10. X. Wei, L. Yang, Z. Chen*, W. Xia, Y. Chen, M. Cao*, N. He*. Molecular weight control of poly-γ-glutamic acid reveals novel insights into extracellular polymeric substance synthesis in Bacillus licheniformis, Biotechnology for Biofuels and Bioproducts, 2024, 17:60
  11. L. Hu, H. Qiu, L. Huang, F. Zhang, V. Tran, J. Yuan, N. He*, M. Cao*. Emerging nonmodel eukaryotes for biofuel production, Current Opinion in Biotechnology, 2023, 84: 103015
  12. Y. Li, Q. Luo, J. Su, G. Dong, M. Cao*, Y. Wang*. Metabolic regulation of Shewanella oneidensis for microbial electrosynthesis: From extracellular to intracellular, Metabolic Engineering, 2023, 80: 1-11
  13. X. Wei, Z. Chen, A. Liu, L. Yang, Y. Xu, M. Cao*, N. He*. Advanced strategies for metabolic engineering of Bacillus to produce extracellular polymeric substances, Biotechnology Advances, 2023, 108199
  14. L. Liu, L. Zhang, J. Wang, M. Cao*, J. Yuan*. Copper-inducible expression system for metabolic engineering of Escherichia coli, Journal of Applied Microbiology, 2023, 134 (6), lxad109
  15. G. Chi, X. Cao, Q. Li, C. Yao, F. Lu, Y. Liu*, M. Cao*, and N. He*. Computationally Guided Enzymatic Studies on Schizochytrium -Sourced Malonyl-CoA:ACP Transacylase. Journal of Agricultural and Food Chemistry, 2022, 70, 43, 13922–13934
  16. M. Cao, V. Tran, J. Qin, A. Olson, S. Mishra, J. Schultz, C. Huang, D. Xie, H. Zhao*. Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone. Biotechnology and Bioengineering, 2022, 119:2529-2540
  17. Y. Xu, L. Yang, H. Wang, X. Wei, Y. Shi, D. Liang, M. Cao*, N. He*. Putative functions of EpsK in teichuronic acid synthesis and phosphate starvation in Bacillus licheniformis. Synthetic and Systems Biotechnology, 2022, 7(2): 815-823
  18. G. Chi, Y. Xu, X. Cao, Z. Li, M. Cao*, Y. Chisti*, N. He*. Production of polyunsaturated fatty acids by Schizochytrium (Aurantiochytrium) spp. Biotechnology Advances, 2022, 55: 107897
  19. C. Lopez, M. Cao*, Z. Yao, Z. Shao*. Revisiting the unique structure of autonomously replicating sequences in Yarrowia lipolytica and its role in pathway engineering. Applied Microbiology and Biotechnology, 2021, 105: 5959-5972
  20. T. Wang*, B. Si, Z. Gong, Y. Zhai, M. Cao*, C. Peng. Co-hydrothermal carbonization of food waste-woody biomass blend: interaction effects on the hydrochar properties and nutrients characteristics. Bioresource Technology, 2020, 316: 123900
  21. M. Cao#, V. Tran#, H. Zhao. Unlocking nature’s biosynthetic potential by directed genome evolution. Current Opinion in Biotechnology, 2020, 66: 95-104    
  22. Y. Zhao, Z. Yao, D. Ploessl, M. Monti, D. Schindler, M. Gao, Y. Cai, M. Qiao, C. Yang*, M. Cao*, Z. Shao*. Leveraging the Hermes transposon to accelerate the development of nonconventional yeast-based microbial cell factories. ACS Synthetic Biology, 2020, 9(7): 1736-1752
  23. M. Cao#, Z. Fatma#, X. Song, P. Hsieh, V. Tran, W. Lyon, M. Sayadi, Z. Shao, Y. Yoshikuni, H. Zhao. A genetic toolbox for metabolic engineering of Issatchenkia orientalis. Metabolic Engineering, 2020, 59: 87-97
  24. M. Cao#, M. Gao#, M. Suástegui, Y. Mei, Z. Shao. Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products. Metabolic Engineering. 2020, 58: 94-132
  25. J. Lian#, C. Schultz#, M. Cao#, M. HamediRad#, H. Zhao. Multi-functional genome-wide CRISPR system for high throughput genotype-phenotype mapping, Nature Communications. 2019, 10:5794
  26. V. Tran#, M. Cao#, Z. Fatma, X. Song, H. Zhao. Development of a CRISPR/Cas9-based tool for gene deletion in Issatchenkia orientalis. mSphere. 2019, 4(3): e00345-19
  27. M. Cao, M. Gao, D. Ploessl, Z. Shao. CRISPR-mediated genome editing and gene repression in Scheffersomyces stipitis. Biotechnology Journal.2018, 13, 1700598
  28. M. Cao#, J. Feng#, S. Sirisansaneeyakul, C. Song, Y. Chisti. Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid. Biotechnology Advances, 2018, 36: 1424-1433
  29. M. Cao, A. Seetharam, A. Severin, Z. Shao. Rapid isolation of centromeres from Scheffersomyces stipitis. ACS Synthetic Biology, 2017, 6(11), 2028-2034
  30. M. Cao, M. Gao, C. Lopez-Garcia, Y. Wu, A. Seetharam, A. Severin, Z. Shao. Centromeric DNA facilitates nonconventional yeast genetic engineering. ACS Synthetic Biology, 2017, 6(8): 1545-1553
  31. J. Zhang, Q. Zhang, R. Ge, A. Liu, B. Chen, Z. Zhang, B. Zhao, J. Yu, Y. Zhao, L. Yu, M. Cao, B. Wang*, X. Huang*. Enantiodivergent Radical Alkylation by Synergistic Lewis-Acid-Enzyme and Photoredox Catalysis, Angewandte Chemie International Edition, 2025, e202500338.
  32. D. Ploessl, Y. Zhao, M. Cao, S. Ghosh, C Lopez-Garcia, M. Sayadi, S Chudalayandi, A. Severin, L. Huang, M. Gustafson, Z. Shao. A repackaged CRISPR platform unlocks the utility of non-homologous end joining in microbial factory engineering. Nature Chemical Biology. 2021, 1-9
  33. Y. Wang#, P. Xue#, M. Cao, T. Yu, S. Lane, H. Zhao. Directed evolution: Methodologies and applications. Chemical Reviews. 2021, 121(20): 12384–12444 
  34. J. Feng, J. Zhang, Y. Ma, Y. Feng, S. Wang, N. Guo, H. Wang, P. Wang, P. Jiménez-Bonilla, Y. Gu, J. Zhou, Z. Zhang, M. Cao, D. Jiang, S. Wang, X. Liu, Z. Shao, I. Borovok, H. Huang, Y. Wang. Renewable fatty acid ester production in Clostridium. Nature Communications. 2021, 12: 4368