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成果及论文

.    Journal Articles  

     (+ Co-first author, * Corresponding author)

    Selected Publications

  1. +Wong, S.H.D.; +Yin, B.; Li, Z.; Yuan, W.; Zhang, Q.; Xie, X.; Tan, Y.; Wong, N.; *Zhang, K.; *Bian, L. Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling. Science Advances, 2023, 9, adg9593.

  2. +Yang, X.; +Yang, B.; +Deng, Y.; +Xie, X.; Qi, Y.; Yan, G.; Peng, X.; *Zhao, P.; *Bian, L. Coacervation-mediated cytocompatible formation of supramolecular hydrogels with self-evolving macropores for 3D multicellular spheroid culture. Advanced Materials, 2023, 202300636.

  3. +Zhao, P.; +Xia, X.; +Xu, X.; Leung, K.K.C.; Rai, A.; Deng, Y.; Yang, B.; Lai, H.; Peng, X.; Shi, P.; Zhang, H.; *Chiu, P.W.R.; *Bian, L. Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy. Nature Communications, 2021, 12, 7162.

  4. +Zhang, K.; +Feng, Q.; Fang, Z.; *Gu, L.; *Bian, L. Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics. Chemical Reviews, 2021, 121(18), 11149-11193.

  5. +Peng, X.; +Xia, X.; +Xu, X.; Yang, X.; Yang, B.; Zhao, P.; Yuan, W.; *Chiu, P.W.R.; *Bian, L. Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations. Science Advances, 2021, Vol. 7, no. 23, eabe8739.

  6. +Yang, B.; +Wei, K.; Loebel, C.; Zhang, K.; Feng, Q.; Li, R.; Wong, D.S.H.; Xu, X.; Lau, C.; Chen, X.; Zhao, P.; Yin, C.; Burdick, J.A.; *Wang, Y.; *Bian, L. Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics. Nature Communications, 2021, 3514.

  7. +Zhao, P.; +Yang, B.; Xu, X.; Lai, N.C.H.; Li, R.; Yang, X.; *Bian, L. Nanoparticle-assembled vacuolated coacervates control macromolecule spatiotemporal distribution to provide a stable segregated cell microenvironment. Advanced Materials, 2021, 33, 9, 2007209.

  8. +Xu, X.; +Xia, X.; +Zhang, K.; Rai, A.; Li, Z.; Zhao, P.; Wei, K.; Zou, L.; Yang, B.; Wong, W.K.R., *Chiu, W.Y.P.; *Bian, L. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Science Translational Medicine, 2020, 12, 558, eaba8014.

  9. Li, R.; Lin, S.; Zhu, M.; Deng, Y.; Chen, X.; Wei, K.; Xu, J.; Li, G.; *Bian, L. Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration. Science Advances, 2019, 5, eaaw3896.

  10. Chen, X.; Li, R.; Wong, S.H.D.; Wei, K.; et al.; Xia, J.; Chen, G.; Li, G.; *Bian, L. Conformational manipulation of scale-up prepared single chain polymeric nanogels for multiscale regulation of cells. Nature Communications, 2019, 10, 2075.

  11. +Kang, H.; +Yang, B.; Zhang, K.; Pan, Q.; Yuan, W.; Li, G.; *Bian, L. Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination. Nature Communications, 2019, 10, 1696.

  12. +Feng, Q.; +Xu, J.; Zhang, K.; Yao, H.; Zheng, N.; Zheng, L.; Wang, J.; Wei, K.; Xiao, X.; *Qin, L; *Bian, L. Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects. ACS Central Science, 2019, 5(3), pp 440–450.

  13. +Kang, H.; +Zhang, K.; Jung, H.J.; Yang, B.; Chen, X.; Pan, Q.; Li, R.; Xu, X.; Li, G.; Dravid, V.; *Bian, L. In situ reversible heterodimeric nanoswitch controlled by metal ion-ligand coordination regulates the adhesion, release, and differentiation of stem cells. Advanced Materials, 2018, 30(44), 201803591.

  14. +Zhang, K.; +Jia, Z.; Yang, B.; Feng, Q.; Xu, X.; Yuan, W.; Li, X.; Chen, X.; Duan, L.; *Wang, D.; *Bian, L. Adaptable hydrogels mediate cofactor-assisted activation of biomarker-responsive drug delivery via positive feedback for enhanced tissue regeneration. Advanced Science, 2018, 5(12), 1800875.

  15. Bian, L.; Guvendiren, M.; Mauck, R.L.; Burdick, J.A.  Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc. Natl. Acad. Sci. USA, 2013, 110(25), 10117-22.


     Full Publication List

  1. +Jiang, X.; +Sun, Y.; Lyu, Y.; Kang, H.; *Zhao, J.; *Zhang, K.; *Bian, L. Hydrogels for ameliorating osteoarthritis: mechanical modulation, anti-inflammation, and regeneration. BMEMat, 2024, 17930462.

  2. +Li, Z.; +Yang, B.; +Yang, Z.; Xie, X.; Guo, Z.; Zhao, J.; Wang, R.; Fu, H.; Zhao, P.; Zhao, X.; Chen, G.; *Li, G.; *Wei, F.; *Bian, L. Supramolecular hydrogel with ultra-rapid cell-mediated network adaptation for enhancing cellular metabolic energetics and tissue regeneration. Advanced Materials, 2024, 202307176.

  3. +Yi, B.; +Li, T.; +Yang, B.; Chen, S.; Zhao, J.; Zhao, P.; Zhang, K.; *Wang, Y.; *Wang, Z.; *Bian, L. Surface hydrophobization of hydrogels via interface dynamics-induced network reconfiguration. Nature Communications, 2024, 15, 239.

  4. +Gao, Y.; +Wang, Y.; Zhang, J.; Zhang, M.; Dai, C.; Zhang, Y.; Zhang, L.; *Bian, L.; *Yang, Y.; *Zhang, K.; *Zhao, Y. Advancing neural regeneration via adaptable hydrogels: enriched with Mg2+ and silk fibroin to facilitate endogenous cell infiltration and macrophage polarization. Bioactive Materials, 2023, 33, 100-113.

  5. +Peng, X.; +Li, Y.; +Liu, M.; Li, Z.; Wang, X.; *Zhang, K.; *Zhao, X.; *Li, G.; *Bian, L. Complex coacervate-derived hydrogel with asymmetric and reversible wet bioadhesion for preventing UV light-induced morbidities. Bioactive Materials, 2023, 30, 62-72.

  6. +Xie, X.; +Li, Z.; +Yang, X.; Yang, B.; Zong. Z.; Wang, X.; Duan, L.; *Lin, S.; *Li, G.; *Bian, L. Biomimetic nanofibrillar hydrogel with cell-adaptable network for enhancing cellular mechanotransduction, metabolic energetics and bone regeneration. Journal of the American Chemical Society, 2023, 145, 28, 15218–15229.

  7. +Wong, S.H.D.; +Yin, B.; Li, Z.; Yuan, W.; Zhang, Q.; Xie, X.; Tan, Y.; Wong, N.; *Zhang, K.; *Bian, L. Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling. Science Advances, 2023, 9, adg9593.

  8. +Li, M.; +Lin, Y.; Zhang, Y.; *Bian, L.; *Zhang, K. Energy-dissipative hydrogels: a promising material for tissue regeneration. Chinese Journal of Chemistry, 2023, 41, 2697.

  9. +Yang, X.; +Gao, S.; +Yang, B.; Yang, Z.; Lou, F.; Huang, P.; Zhao, P.; Guo, J.; Fang, H.; Chu, B.; He, M.; Wang, N.; Chan, A.H.L.; Chan, R.H.F.; *Wang, Z.; *Bian, L.; *Zhang, K. A bioinspired tumor-targeting and biomarker-activatable cell-material interfacing system enhances osteosarcoma treatment via biomineralization. Advanced Science, 2023, 202302272.

  10. +Zhao, P.; +Guo, J.; Jiang, T.; Xu, X.; Chen, S.; Li, Z.; *Xu, J.; *Li, G.; *Bian, L. Vacuolated coacervate mediates the bimodal release kinetics of diverse macromolecular drugs in vivo. Materials Today, 2023, 66, 26-35.

  11. +Yang, X.; +Yang, B.; +Deng, Y.; +Xie, X.; Qi, Y.; Yan, G.; Peng, X.; *Zhao, P.; *Bian, L. Coacervation-mediated cytocompatible formation of supramolecular hydrogels with self-evolving macropores for 3D multicellular spheroid culture. Advanced Materials, 2023, 202300636.

  12. Zhao, P.; Qu, F.; Fu, H.; Zhao, J.; Guo, J.; Xu, J.; Ho, Y.-P.; Chan, M.K.; *Bian, L. Water-immiscible coacervate as a liquid magnetic robot for intravascular navigation. Journal of the American Chemical Society, 2023, 145, 6, 3312–3317.

  13. +Li, J.; +Ma, J.; +Feng, Q.; Xie, E.; Meng, Q.; Shu, W.; Wu, J.; *Bian, L.; *Han, F.; *Li, B. Building osteogenic microenvironments with a double-network composite hydrogel for bone repair. Research, 2023, 6, 0021.

  14. Zhao, P.; Wang, Z.; Xie, X.; Jiang, T.; Lai, N.C.-H.; Yang, B.; Yi, B.; Fu, H.; Zhang, K.; *Li, G.; *Wang, Y.; *Bian, L. Directed conformational switching of a zinc finger analogue regulates the mechanosensing and differentiation of stem cells. Angew. Chem. Int. Ed., 2022, 202203847.

  15. Xu, X.; Feng, Q.; Ma, X.; Deng, Y.; Zhang, K.; Ooi, H.S.; Yang, B.; *Zhang, Z.-Y.; *Feng, B.; *Bian, L. Dynamic gelatin-based hydrogels promote the proliferation and self-renewal of embryonic stem cells in long-term 3D culture. Biomaterials, 2022, 121802.

  16. +Peng, X.; +Li, Y, Li, T.; Li, Y.; Deng, Y.; Xie, X.; *Wang, Y.; *Li, G.; *Bian, L. Coacervate-derived hydrogel with effective water repulsion and robust underwater bioadhesion promotes wound healing. Advanced Science, 2022, 202203890.

  17. +Yao, Z.; +Yuan, W.; Xu, J.; Tong, W.; Mi, J.; Chow, D.H.K; Li, Y.; Yao, H.; Li, X.; Xu, S.; Guo, J.; Zhu, Q.; Ho, P.C.; *Bian, L.; *Qin, L. Magnesium-encapsulated injectable hydrogel and 3D-engineered polycaprolactone conduit facilitate peripheral nerve regeneration. Advanced Science, 2022, 2202202102.

  18. +Deng, Y.; +Li, R.; +Wang, H.; Yang, B.; Shi, P.; Zhang, Y.; *Yang, Q.; *Li, G.; *Bian, L. Biomaterial-mediated presentation of jagged-1 mimetic ligand enhances cellular activation of notch signaling and bone regeneration. ACS Nano, 2022, 16, 1, 1051–1062.

  19. *Zhao, Y.; Liu, J.; Gao, Y.; Xu, Z.; Dai C.; Li, G.; Sun, C.; *Yang, Y.; *Zhang, K. Conductive biocomposite hydrogels with multiple biophysical cues regulate Schwann cell behaviors. Journal of Materials Chemistry B, 2022, 10, 1582-1590.

  20. Oh, J.; Xia, X.; Wong, W.K.R.; Wong, S.H.D.; Yuan, W.; Wang, H.; Lai, C.H.N.; Tian, Y.; Zhang, H.; Zhang, Y.; Li, G.; *Lin, Y.; *Bian, L. The effect of the nanoparticle shape on T cell activation. Small, 2022, 202107373.

  21. +Deng, Y.; +Zhang, X.; +Li, R.; Li, Z.; Yang, B.; Shi, P.; Zhang, H.; Wang, C.; Wen, C.; *Li, G.; *Bian, L. Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling. Biomaterials, 2022, 281, 121316.

  22. +Li, Z.; +Wang, H.; +Zhang, K.; Yang, B.; Xie, X.; Yang, Z.; Kong, L.; Shi, P.; Zhang, Y.; Ho, Y.P.; *Zhang, Z.; *Li, G.; *Bian, L. Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration. Bioactive Materials, 2022, 13, 9-22.

  23. +Xia, X.; +Xu, X.; Xie, X.; Lai, H.; Xue, J.; Zhang, W.; Rai, A.; Li, Z.; Peng, X.; Zhao, P.; *Bian, L.; *Chiu, P.W.R. Adhesive hemostatic hydrogel with ultrafast gelation arrests acute upper gastrointestinal hemorrhage in pigs. Advanced Functional Materials, 2021, 202109332.

  24. +Zhao, P.; +Xia, X.; +Xu, X.; Leung, K.K.C.; Rai, A.; Deng, Y.; Yang, B.; Lai, H.; Peng, X.; Shi, P.; Zhang, H.; *Chiu, P.W.R.; *Bian, L. Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy. Nature Communications, 2021, 12, 7162. 

  25. +Yuan, X.; +Yuan, W.; Ding, L.; Shi, M.; Luo, L.; Wan, Y.; Oh, J.; *Zhou, Y.; *Bian, L.; *Deng, Y.B. Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation. Biomaterials, 2021, 279, 121190.

  26. +Zhang, J.; +Wong, S.H.D.; Wu, X.; Lei, H.; Qin, M.; Shi, P.; *Wang, W.; *Bian, L.; *Cao, Y. Engineering photoresponsive ligand tethers for mechanical regulation of stem cells. Advanced Materials, 2021, 2105765.

  27. +Zhang, K.; +Feng, Q.; Fang, Z.; *Gu, L.; *Bian, L. Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics. Chemical Reviews, 2021, 121(18), 11149-11193.

  28. +Peng, X.; +Xia, X.; +Xu, X.; Yang, X.; Yang, B.; Zhao, P.; Yuan, W.; *Chiu, P.W.R.; *Bian, L. Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations. Science Advances, 2021, Vol. 7, no. 23, eabe8739.

  29. +Yuan, W.; +Wang, H.; +Fang, C.; Yang, Y.; Xia, X.; Yang, B.; *Lin, Y.; *Li, G.; *Bian, L. Microscopic local stiffening in supramolecular hydrogel network expedites stem cell mechanosensing in 3D and bone regeneration. Materials Horizons, 2021, 8, 1722-1734.

  30. +Peng, X.; +Xu, X.; Deng, Y.; Xie, X.; Xu, L.; Xu, X.; Yuan, W.; Yang, B.; Yang, X.; *Xia, X.; *Li Duan, L.; *Bian, L. Ultrafast self-gelling and wet adhesive powder for acute hemostasis and wound healing. Advanced Functional Materials, 2021, 202102583.

  31. +Yang, B.; +Wei, K.; Loebel, C.; Zhang, K.; Feng, Q.; Li, R.; Wong, D.S.H.; Xu, X.; Lau, C.; Chen, X.; Zhao, P.; Yin, C.; Burdick, J.A.; *Wang, Y.; *Bian, L. Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics. Nature Communications, 2021, 3514.

  32. +Wong, S.H.D.; +Xu, X.; Chen, X., Xing, Y.; Xu, L.; Lai, N.C.H.; Oh, J.; Wong, R.W.K.; Wang, X.; Han, S.; You, W., Shuai, X.; Wong, N., *Tan, Y.; *Duan, L.; *Bian, L. Manipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and tumorigenicity. Nano Letters, 2021, 21, 7, 3225–3236.

  33. Li, R.; Li Y.; Mu, M.; Yang, B.; Chen, X.; Lee, W.Y.W.; Ke, Y.; *Yung W.H.; *Tang B. Z.; *Bian, L. Multifunctional nanoprobe for the delivery of therapeutic siRNA and real time molecular imaging of Parkinson's disease biomarkers. ACS Appl. Mater. Interfaces, 2021, 13, 10, 11609–11620.

  34. +Zhao, P.; +Yang, B.; Xu, X.; Lai, N.C.H.; Li, R.; Yang, X.; *Bian, L. Nanoparticle-assembled vacuolated coacervates control macromolecule spatiotemporal distribution to provide a stable segregated cell microenvironment. Advanced Materials, 2021, 33, 9, 2007209.

  35. Zhu, M.; Zhang, K., Feng, L.; Lin, S.; Pan, Q.; *Bian, L.; *Li, Gang. Surface decoration of development-inspired synthetic N-Cadherin motif via Ac-BP promotes osseointegration of metal implants. Bioactive Materials, 2021, 6, 5, 1353-1364

  36. +Xu, X.; +Xia, X.; +Zhang, K.; Rai, A.; Li, Z.; Zhao, P.; Wei, K.; Zou, L.; Yang, B.; Wong, W.K.R., *Chiu, W.Y.P.; *Bian, L. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Science Translational Medicine, 2020, 12, 558, eaba8014.

  37. +Yuan, W.; +Li, Z.; +Xie, X.; Zhang, Z; *Bian, L. Bisphosphonate-based nanocomposite hydrogels for biomedical applications. Bioactive Materials, 2020, 5, 4, 819-831.

  38. Wen, G.;  Li, X.; Zhang, Y.; Han, X.; Xu, X.; Liu, C.; Chan, W.Y.K; Lee, C.S.; *Yin, C.; *Bian, L.; *Wang, L. Effective phototheranostics of brain tumor assisted by near-infrared-II light-responsive semiconducting polymer nanoparticles. ACS Appl. Mater. Interfaces, 2020, 12, 30, 33492–33499.

  39. Zhao, P.; Yin, C.; Zhang, Y.; Chen, X.; Yang, B.; Xia, J.; *Bian, L. Mussel cuticle-mimetic ultra-tough and self-healing elastomers with double-locked nanodomains exhibit fast stimuli-responsive shape transformation. Journal of Materials Chemistry A, 2020, 8, 12463-12471.

  40. Wong, S.H.D.; Wong, W.K.R.; Lai, N.C.H.; Oh, J.; Li, Z.; Chen, X.; Yuan, W.; *Bian, L. Soft polymeric matrix as a macroscopic cage for magnetically modulating reversible nanoscale ligand presentation. Nano Letters, 2020, 20, 5, 3207-3216.

  41. +Chen, X.; +Lai, N.C.H.; +Wei, K.; Li, R.; Cui, M.; Yang, B.; Wong, S.H.D.; Deng, Y.; Li, J.; Shuai, X.; *Bian, L. Biomimetic presentation of cryptic ligands via single-chain nanogels for synergistic regulation of stem cells. ACS Nano, 2020, 14, 4, 4027-4035.

  42. Yang, X.; Jiang, X.; Yang, H.; *Bian, L.; *Chang, C.; *Zhang, L. Biocompatible cellulose-based supramolecular nanoparticles driven by host–guest interactions for drug delivery. Carbohydrate Polymers, 2020, 237, 116114.

  43. +Yin, C.;  +Li, X.; +Wen, G.; Yang, B.; Zhang, Y.; Chen, X.; Yang, X.; Zhao, P.; Li, S.; Li, R.; *Wang, L.; *Lee, C.S.; *Bian, L. Organic Semiconducting polymer amphiphile for near-Infrared-II light triggered phototheranostics. Biomaterials, 2019, 232: 119684.

  44. Yin, B.; et al.; *Bian, L.; *Tian, X.Y.; *Chan, M.N.; *Choi, C.H. Intrapulmonary cellular-level distribution of inhaled nanoparticles with defined functional groups and its correlations with protein corona and inflammatory response. ACS Nano, 2019, 13(12):14048-14069.

  45. Li, R; Lin, S., Zhu, M., Deng, Y., Chen, X., Wei, K., Xu, J., Li, G.; *Bian, L. Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration. Science Advances, 2019, 5, eaaw3896.

  46. Zhou, H.; Liang, C.; Wei, Z.; Bai, Y.; Bhaduri, S.B; Webster, T. J.; *Bian, L.; *Yang, L. Injectable biomaterials for translational medicine. Materials Today,  2019, 28: 81.

  47. Chen, X.; Li, R; Wong, S.H.D.; Wei, K.; et al.; Xia, J.; Chen, G.; Li, G.; *Bian, L. Conformational manipulation of scale-up prepared single chain polymeric nanogels for multiscale regulation of cells. Nature Communications, 2019, 10, 2075.

  48. +Xu, J.; +Feng, Q.; +Lin, S.; Yuan, W.; Li, R.; Li, J.; Wei, K.; Chen, X.; Zhang, K.; Yang, Y.; Wu, T.; Wang, B.; Zhu, M.; Guo, R.; *Li, G.; *Bian, L. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials, 2019; 210:51-61.

  49. Wei, K.; Chen, X.; Zhao, P.; Feng, Q.; Yang, B.; Li, R.; *Zhang Z.; *Bian, L. Stretchable and bio-adhesive supramolecular hydrogels activated by a one-stone-two-bird post-gelation functionalization method. ACS Appl. Mater. Interfaces, 2019, 11 (18), pp 16328–16335.

  50. +Kang, H.; +Yang, B.; Zhang, K.; Pan, Q.; Yuan, W.; Li, G.; *Bian, L. Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination. Nature Communications, 2019, 10, 1696.

  51. +Zhang, K.; +Yuan, W.; Wei, K.; Yang, B.; Chen, X.; Li, Z.; *Zhang, Z.; *Bian, L. Highly dynamic nanocomposite hydrogels self-assembled by metal ion-ligand coordination, Small, 2019, 201900242.

  52. +Feng, Q.; +Xu, J.; Zhang, K.; Yao, H.; Zheng, N.; Zheng, L.; Wang, J.; Wei, K.; Xiao, X.; *Qin, L; *Bian, L. Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects. ACS Central Science, 2019, 5(3), pp 440–450.

  53. +Kang, H.; +Wong, S.H.D.; Pan, Q.; Li, G.; *Bian, L. Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages. Nano Letters, 2019, 19(3), 1963.

  54. +Wong, S.H.D.; +Yin, B.; Lin S.; Yang, B.; Li, R.; Feng, F.; Yang, H.; Zhang, L.; Yang, Z.; Li, G.; *Choi, C. H.; *Bian, L. Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells. Advanced Functional Materials, 2019, 29(8), 201806822.  

  55. +Kang, H.; +Zhang, K.; Jung, H.J.; Yang, B.; Chen, X.; Pan, Q.; Li, R.; Xu, X.; Li, G.; Dravid, V.; *Bian, L. In situ reversible heterodimeric nanoswitch controlled by metal ion-ligand coordination regulates the adhesion, release, and differentiation of stem cells. Advanced Materials, 2018, 30(44), 201803591.

  56. +Yin, C.; +Wen, G.; Liu, C.; Yang, B.; Lin, S.; Huang, J.; Zhao, P.; Wong, S.H.D., Zhang, K.; Chen, X.; Li, G.; Jiang, X.; *Pu, K.; *Wang, L.; *Bian, L. Organic semiconducting polymer nanoparticles for photoacoustic labelling and tracking of stem cells in the second near-infrared window. ACS Nano, 2018, 12(12), 12201.

  57. +Zhang, K.; +Jia, Z.; Yang, B.; Feng, Q.; Xu, X.; Yuan, W.; Li, X.; Chen, X.; Duan, L.; *Wang, D.; *Bian, L. Adaptable hydrogels mediate cofactor-assisted activation of biomarker-responsive drug delivery via positive feedback for enhanced tissue regeneration. Advanced Science, 2018, 5(12), 1800875.

  58. +Kang, H.; +Zhang, K.; Pan, Q.; Lin, S.; Wong, S.H.D.; Li, J.; Lee, Y. W.; Yang, B.; Han, F.; *Li, B.; *Bian, L. Remote control of intracellular calcium using upconversion nanotransducers regulates stem cell differentiation in vivo. Advanced Functional Materials, 2018, 201802642.  

  59. Li, J.; Lee, Y. W.; Wu, T.; Leung, Y.T.C; Xu, J.; Wong, S.H.D.; Li, R.; *Li, G.; *Tang, B.Z.; *Bian, L. Detection of matrix metallopeptidase 13 for monitoring stem cell differentiation and early diagnosis of osteoarthritis by fluorescent light-Up probes with aggregation-induced emission characteristics. Advanced Biosystems, 2018, 2(10), 201800010.

  60. +Chen, X.; +Dong, C.; +Wei, K.; +Yao, Y.; et al., Feng, Q.; Zhang, K.; Mak, A.; *Bian, L. Supramolecular hydrogels cross-linked by preassembled host-guest PEG cross-linkers resists excessive, ultrafast, and non-resting cyclic compression. NPG Asia Materials, 2018, 10, 788–799.   

  61. +Kang, H.; Jung, H.J.; Kim, S.K.; Wong, S.H.D.; Lin, S.; Li, G.; Dravid, V.; *Bian, L. Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages. ACS Nano, 2018, 12(6), 5978-5994.

  62. +Li, R.; +Li, J.; Xu, J.; Wong, S.H.D.; Chen, X.; Yuan, W.; *Bian, L. Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells. Biomaterials, 2018,173, 87–99.

  63. +Kang, H.; +Jung, H.J.; Wong, S.H.D.; Kim, S.K.; Lin, S.; Chan, K.F.; Zhang, L.; Li, G.; Dravid, V.; *Bian, L. Remote control of heterodimeric magnetic nanoswitch regulates the adhesion and differentiation of stem cells. Journal of the American Chemical Society, 2018, 140(18), 5909-5913.

  64. +Kang, H.; +Zhang, K.; Wong, S.H.D.; et al.; *Bian, L. Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization. Biomaterials, 2018,178, 681-696.

  65. Zhu, M.; Wei, K.; Lin, S.; Wu, C.C.; *Li, G.; *Bian, L. Bio-adhesive polymersome for localized and sustained drug delivery at pathological sites with harsh enzymatic and fluidic environment via supramolecular host-guest complexation. Small, 2018, 201702288.

  66. Chen, H.; Yan, X.; Feng, Q.; Zhao, P.; Xu, X. Ng, D.H.L.; *Bian, L. Citric acid/cysteine modified cellulose-based materials: green preparation and its applications in anti-counterfeiting, chemical Sensing, and UV shielding. ACS Sustain. Chem. Eng., 2017, 5(12), 11387–11394.

  67. Zhao, P.; Wei, K.; Feng, Q.; Chen, H.; Wong, S.H.D.; Chen, X.; Wu, C.C.; *Bian, L. Mussel-mimetic hydrogels with defined cross-linkers achieved by controlled catechol dimerization exhibiting tough adhesion for wet biological tissues. Chemical Communications, 2017, 53, 12000-12003.  

  68. Feng, Q.; Wei, K.; Zhang, K.; Yang, B.; Tian, F.; Wang, G.; *Bian, L. One-pot solvent exchange preparation of non-swellable, thermoplastic, stretchable, and adhesive supramolecular hydrogels based on dual synergistic physical crosslinking. NPG Asia Materials, 2018, 10, e455.

  69. +Kang, H.; +Kim, M.; +Feng, Q.; Lin, S.; Wei, K.; Li, R.; Choi, C. J.; Kim, T.; Li, G.; *Oh, J. M.; *Bian, L. Nanolayered hybrid mediates synergistic co-delivery of ligand and ligation activator for inducing stem cell differentiation and tissue healing. Biomaterials, 2017, 149, 12-28.

  70. +Zhang, K.; +Lin, S.; Feng, Q.; Dong, C.; Yang, Y.; *Li, G.; *Bian, L. Bioactive nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration. Acta Biomaterialia, 2017, 64, 389-400.

  71. Wei, K.; Chen, X.; Li, R.; Feng, Q.; *Bian, L. Multivalent host-guest hydrogels as fatigue resistant 3D matrix for excessive mechanical stimulation of encapsulated cells. Chemistry of Materials, 2017, 29(20), 8604-8610.

  72. +Kang, H.; +Kim, S.; Wong, S.H.D.; Jung, H.J.; Lin, Si.; Zou, K.; Li, R.; Li, G.; *Dravid, V.; *Bian, L. Remote manipulation of ligand nano-oscillations regulates adhesion and polarization of macrophages in vivo. Nano Letters, 2017, 17(10), 6415-6427

  73. +Kang, H.; +Wong, S.H.D.; Yan, X.; Jung, H.J.; King, S.K.; Lin, Si.; Wei, K.; Li, G.; *Dravid, V.; *Bian, L. Remote control of multi-Modal nanoscale ligand oscillations regulates stem cell adhesion and differentiation. ACS Nano, 2017, 11(10), 9636-9649.

  74. +Li, R.; +Xu, J.; Wong, S.H.D.; Li, J.; Zhao, P.; *Bian, L.; Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/β-catenin signaling. Biomaterials, 2017, 145, 33-43.

  75. +Ouyang, X.; +Zhang, K.; Wu, J.; Wong, S.H.D.; Feng, Q.; *Bian, L.; *Zhang, A. Optical ¦Ì-Printing of Cellular-Scale Microscaffold Arrays for 3D Cell Culture, Scientific Report, 2017, 7(1), 8880.

  76. Zhang, K.; Feng, Q.; Xu, J.; Xu, X.; Yeung, K.W.K.; *Bian, L. Self-assembled injectable nanocomposite hydrogels stabilized by bisphosphonate-magnesium (Mg2+) coordination regulates the differentiation of encapsulated stem cells via dual crosslinking. Advanced Functional Materials, 2017, 27, 1701642.

  77. Li, J.; Yan, X.; Leung, Y.T.C; Wong, S.H.D.; Xu, J.; Li, R.; Zhao, Y.; Yung, Y.Y.C; Zhao, E.; *Tang, B.Z.; *Bian, L. Photo-controlled siRNA delivery and biomarker-triggered AIEgen emission by upconversion NaYF4:Yb3+Tm3+@SiO2 nanoparticles for inducing and monitoring stem cell differentiation. ACS Appl. Mater. Interfaces, 2017, 7b00845.

  78. +Wong, S.H.D.; +Li, J.; Yan, X.; Wang, B., Zhang, L.; *Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells. Nano Letters, 2017, 17(3), 1685-1695.

  79. +Feng, Q.; +Lin, S..; Zhang, K.; Dong, C.,  Sun, Y.; Huang, H.; Yan, X.; Zhang, L.; Li, G.; *Bian, L. Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy. Acta Biomaterialia, 2017, 53, 329-342.

  80. +Xu, Y.; +Wei, K.; Zhao, P.; Feng, Q.; Choi, C.K. ; *Bian, L. Preserving the adhesion of catechol-conjugated hydrogels by thiourea-quinone coupling. Biomaterials Science, 2016, 4, 1726-1730.

  81. +Li, J.; +Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Wong, S.H.; Li, R.; *Li, G.; *Bian, L. Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials, 2016, 110, 1-10.

  82. Zhu, M.; Feng, Q.; Sun, Y.; Li, G.; *Bian, L. Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. J Biomed Mater Res B Appl Biomater, 2017, 105(8), 2292-2300. 

  83. +Feng, Q.; +Wei, K.; Lin, S.; Xu, Z.; Sun, Y.; Shi, P.; Li, G.; *Bian, L. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials, 2016, 101, 217-28.

  84. Huang, H.; Xu, J.; Wei, K.; Xu, Y.; Choi, C. K; Zhu, M.; *Bian, L. Bioactive nanocomposite poly (ethylene glycol) hydrogels crosslinked by multifunctional layered double hydroxides nano-crosslinkers. Macromolecular Bioscience, 2016, 16(7), 1019-26.

  85. +Xu, J.; +Li, J.; Lin, S.; Wu, T.; Huang, H.; Zhang, K.; Su, Y.;  Yeung, K.W.K.; Li, G.; *Bian, L. Nanocarrier-mediated codelivery of small molecular drugs and siRNA to enhance chondrogenic differentiation and suppress hypertrophy of human mesenchymal stem cells. Advanced Functional Materials, 2016, 26(15), 2463-72.

  86. Wei, K.; Zhu, M.; Su, Y.; Xu, J.; Feng, Q.; Lin, S.; Wu, T.; Xu, J.; Tian, F.; Xia, J.; Li, G.; *Bian, L. Robust biopolymeric supramolecular “Host-Guest Macromer” hydrogels reinforced by in situ formed multivalent nanoclusters for cartilage regeneration. Macromolecules, 2016, 49(3), 866–875.

  87. Li, J.; Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Li, G.; Xia, J.; *Bian, L. Multifunctional quantum dot nanoparticles for effective differentiation and long-term tracking of human mesenchymal stem cells in vitro and in vivo. Advanced Healthcare Materials, 2016, 5(9), 1049-57.

  88. Zhu, M.; Lin, S.; Sun, Y.; Feng, Q.; Li, G.; *Bian, L. Hydrogels functionalized with N-cadherin mimetic peptide enhance osteogenesis of hMSCs by emulating the osteogenic niche. Biomaterials, 2016, 77, 44–52.

  89. Choi, C.K.; Xu, Y.; Wang, B.; Zhu, M.; Zhang, L.; *Bian, L. Substrate coupling strength of integrin-binding ligands modulates adhesion, spreading, and differentiation of Human mesenchymal stem cells. Nano Letters, 2015, 14, 15(10), 6592-600.

  90. Choi, C.K.; Li, J.; Wei, K.; Xu, Y.; Ho, L.W.; Zhu, M.; To, K.W.; *Choi, C.H.; *Bian, L. A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc.,  2015,137(23), 7337-46.

  91. +Feng, Q.; +Zhu, M.; Wei, K.; *Bian, L. Cell-mediated degradation regulates human mesenchymal stem Cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels. PLoS ONE, 2014, 9(6).  

  92. +Zhu, M.; +Feng, Q.; *Bian, L. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels.  Acta Biomaterialia, 2014, 10(3), 1333-40.

  93. Bian, L.; Guvendiren, M.; Mauck, R.L.; Burdick, J.A.  Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc. Natl. Acad. Sci. USA, 2013, 110(25), 10117-22.

  94. Bian, L.; Hou, C., Tous, E.; Rai R.; Mauck, R.L.; Burdick, J.A. The Influence of Hyaluronic Acid Hydrogel Crosslinking Density and Macromolecular Diffusivity on Human MSC Chondrogenesis and Hypertrophy. Biomaterials, 2013, 34(2), 413-21.

  95. Bian, L.; Zhai, D.Y.; Tous, E.; Rai R.; Mauck, R.L.; Burdick, J.A. Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials, 2011, 32(27), 6425-34.

  96. Bian, L.; Zhai, D.Y.; Zhang, E.C.; Mauck, R.L.; Burdick, J.A. Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue Engineering Part A, 2012, 18(7-8), 715-24.

  97. Bian, L.; Zhai, D.Y.; Mauck, R.L.; Burdick, J.A. Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Engineering Part A, 2011, 17(7-8), 1137-45.

  98. Bian, L.; Stoker, A.M.; Marberry, K.M; Ateshian, G.A.; Cook, J.L.; Hung, C.T. Effects of dexamethasone on the functional properties of cartilage explants during long term culture. Am. J. Sports Med., 2010, 38(1), 78-85.

  99. Bian, L., Fong, J.V., Lima, E.G., Stoker, A.M., Ateshian, G.A., Cook, J.L., Hung, C.T. Dynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes. Tissue Engineering Part A, 2010, 16(5), 1781-90.

  100. Bian, L., Ng, K.W., Lima, E.G., Williams, D.Y., Ateshian, G.A., Hung, C.T. Influence of temporary chondroitinase ABC-induced GAG suppression on maturation of tissue engineered cartilage. Tissue Engineering Part A, 2009, 15(8), 2065-72.

  101. Bian, L., Kaplun, M., Williams, D.Y., Ateshian, G.A., Hung, C.T. Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long term culture. Journal of Biomechanics, 2009, 42(3), 286-90.

  102. Bian, L., Angione, S.L., Ng, K.W., Lima, E.G., Williams, D.Y., Mao D.Q., Ateshian, G.A., Hung, C.T. Influence of decreasing nutrient path length on the development of engineered cartilage. Osteoarthritis and Cartilage, 2009, 17(5), 677-85.

  103. Bian, L., Lima, E.G., Angione, S.L., Ng, K.W., Williams, D.Y., Xu, D., Stoker, A.M., Cook, J.L., Ateshian, G.A., Hung, C.T. Mechanical and biochemical characterization of cartilage explants in serum-free culture. Journal of Biomechanics, 2008, 41(6), 1153-1159.

    Patents

  1. US patent (US 2010/0036492A1): Osteochondral implants, arthroplasty methods, devices and systems. Inventors: Hung C.T, Ateshian, G.A, Lima, E.G., Cook, J.L., Bian, L.
  2. US patent (US 9889086B2): Bioadhesive and injectable hydrogel. Inventors: Bian. L; Feng, Q.; Wei, K.; Lin, S.; Li, G. Patent date: Feb 13, 2018.
  3. US patent (US10240190B2): Nano-constructs for polynucleotide delivery. Inventors: Bian L, Choi, C.H. Choi, C.K.; Patent date: March 26, 2019.
  4. US/China patent (US10208104B2): Fast and efficient conjugation method based on thiourea-catechol coupling. Inventors: Bian, L.; Xu, Y.; Zhao, P.; Wei, K. Patent date: Feb 19, 2019.
  5. US/China patent: Scalable and versatile method for preparing single-chain nanoparticles. Inventors: Chen, X..; Wei, K.; Bian, L.
  6. US/China patent: Injectable hydrogels that promote mineralization and afford sustained release of bioactive ions. Inventors: Zhang, K.; Bian, L.

    Book Chapters

  1. Injectable Smart Hydrogels for Biomedical Applications, Q. Ling, X. Chen, K. Zhang, RSC, 2023.

  2. Multicomponent Hydrogels: Smart Materials for Biomedical Applications, B. Yang, J. Xu, K. Zhang, RSC, 2023.

  3. Biomedical Nanotechnology: Methods and Protocols, Second edition, C.K.K. Choi, C.H.J. Choi, L. Bian, Springer, 2016.

  4. Bio-Inspired Materials for Biomedical Engineering, L. Bian, Wiley, 2013.