赵鹏超
PI,教授
2023 — 至今 华南理工大学生物医学科学与工程学院 教授
2019 — 2022 香港中文大学 博士后
2015 — 2019 香港中文大学生物医学工程系 博士
2011 — 2015 山东大学 化学学士
凝聚体(Coacervate)是一种通过液-液相分离(Liquid-liquid phase separation, LLPS)形成的、富含分子的高浓度凝聚液相(或液滴状凝聚相),它是分散在水中的分子在弱非共价相互作用驱动下发生相分离的产物。凝聚体及其衍生的水凝胶相变行为,在生物系统中扮演着多种关键角色,揭示了跨越亚细胞结构(如无膜细胞器)、细胞外基质构筑、宏观生物界面粘附,乃至于生命起源(原细胞,Protocell)的一种普适性机制。
体外设计合成液-液相分离诱导的凝聚体有望作为一类新型生物材料用于解决生物医学前沿挑战。课题组致力于发展组成模块化的液-液相分离生物材料(凝聚体) 的通用设计策略;探究凝聚体以及凝聚体-水凝胶相转变应用于细胞/组织仿生、药物递送载体、疾病免疫治疗、组织工程与再生医学等领域的优势及功效机制。在Nat. Chem.、Sci. Adv.、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Mater. Today等期刊以通讯作者或第一作者发表论文10余篇,申请/获批国内外专利6项。主持国家自然科学基金优青(海外)项目、国家重点研发计划重点专项课题、国家自然科学基金面上项目等。
2023年入职后的代表性通讯工作(*):
- +Sirong Chen, +Tianshen Jiang, Xiaorou Qiu, Ruitong Luo, Haiyang Yao, Ruinan Wang, Zhuo Li, *Pengchao Zhao, *Liming Bian. Cartilage-binding coacervate as biomimetic therapeutics-laden lubricant alleviates osteoarthritis by reducing joint friction and inflammation. In Revision.
- +Ruinan Wang, +Hao Li, +Bo Yi, Sirong Chen, Qiangjun Ling, Tiansheng Jiang, Hao Fu, *Xuefeng Yang, *Pengchao Zhao, *Liming Bian. Enhanced biofilm infiltration by drug-laden coacervate for treating refractory infections. In Revision.
- +Bo Yi, +Hao Li, Sirong Chen, Honghui Lian, Fengming Tan, Haiyang Yao, Xiayi Xu, *Kunyu Zhang, *Pengchao Zhao, *Liming Bian. Superspreading and ultra-infiltrative coacervate mediates strong underwater adhesion on hydrated and lipidic substrates. Nature Chemistry, 2026, Accepted.
- Qingqiao Xie, Chenchen Yan, Zifeng Yang, Xiayi Xu, *Yong Li, *Pengchao Zhao, *Liming Bian. Fluidic microgel assemblies with enhanced oral delivery of biologics alleviate colonic inflammation in murine and canine models. Science Advances, 2025, eadv6994.
- +Xian Xie, +Tianjie Li, Linjie Ma, Jiahao Wu, Yajing Qi, Boguang Yang, Zhuo Li, Zhinan Yang, Kunyu Zhang, Zhiqin Chu, To Ngai, Jiang Xia, *Yi Wang, *Pengchao Zhao, *Liming Bian. A designer minimalistic model parallels the phase separation-mediated assembly and biophysical cues of extracellular matrix. Nature Chemistry, 2025, 17, 1216.
- +Tianshen Jiang, +Sirong Chen, +Jingwen Xu, Yuxiao Zhang, Hao Fu, Qiangjun Ling, Yan Xu, Xiangyu Chu, Ruinan Wang, Liangcong Hu, Hao Li, Weitong Huang, *Liming Bian, *Pengchao Zhao, *Fuxin Wei. Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs. Nature Communications, 2024, 15, 5460.
- +Xuefeng Yang, +Boguang Yang, +Yingrui Deng, +Xian Xie, Yanwei Qi, Guoqing Yan, Xin Peng, *Pengchao Zhao, *Liming Bian. Coacervation-mediated cytocompatible formation of supramolecular hydrogels with self-evolving macropores for 3D multicellular spheroid culture. Advanced Materials, 2023, 202300636.