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2025
Guangliang Tu†, Ke Xiao†, Xiaoping Chen†, Haoran Xu†, Haifeng Zeng, Fangjiang Zhang, Xiaosong Xue*, and Xiaheng Zhang*. Direct deaminative functionalization with N-nitroamines. Nature 2025, 648, 341. (†co-first author)
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Weitai Fan†, Yuang Cui†, Beibei Zhan†, Yizhou Chen, Lei Bao, Yufan Liang, and Xiaheng Zhang*. Biomimetic 1,2-amino migration via photoredox catalysis. Nature Chemistry 2025, 17, 941. Highlighted by Synfacts 2025, 21, 600.
Lu Wang†, Hongxiang Yang†, Jianwen Cui, Xiaoping Chen*, Biao Yu, and Xiaheng Zhang*. Rewriting lysine reactivity: Lysine-targeted bioconjugation via biomimetic polarity reversal for diversified biomolecule modification. Chem 2025, doi.org/10.1016/j.chempr.2025.102744 (†co-first author)
Kaihang Wei, Yulian Tang, Xiaoping Chen,* Beibei Zhan,* and Xiaheng Zhang*. Stereodivergent Deacylative Mizoroki–Heck Reaction of Unstrained Ketones. Angew. Chem. Int. Ed. 2025, e202518599.
Minxu Shi†, Lu Wang†, Lei Bao, Tianyu Wang, Nicholas Su, Xiaoping Chen, and Xiaheng Zhang*. Photocatalytic Arene C−H Amination with Aromatic N-Heterocyclic Radicals. ACS Catalysis 2025, 15, 16863.
Shen Cao†, Haobo Zhang†, Mingshuo Chen, Niming Zhu, Beibei Zhan, Peng Xu, Xiaoping Chen*, Biao Yu* and Xiaheng Zhang*. Regiodivergent Functionalization of Protected and Unprotected Carbohydrates using Photoactive 4-Tetrafluoropyridinylthio Fragment as an Adaptive Activating Group. Angew. Chem. Int. Ed. 2024, e202412436. (†co-first author)
Selected as Hot Paper by Angew. Chem.
Zhibin Li, Lei Bao, Kaihang Wei, Beibei Zhan, Ping Lu, and Xiaheng Zhang*. Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Photoexcited Palladium Catalysis. JACS Au. 2024, 4, 4223.
Boyi Zhang,† Hui Bai,† Beibei Zhan,†* Kaihang Wei, Shenyou Nie*, and Xiaheng Zhang*. Deacylative arylation and alkynylation of unstrained ketones. Science Advances 2024, 10, eado0225. (†co-first author)
Selected as a "Literature Coverage" by Synform
Beibei Zhan, and Xiaheng Zhang*. Deacylative Arylation and Alkynylation of Unstrained Ketones. Synform 2024, 08, A126-A129.
Mingshuo Chen, Yuang Cui, Xiaoping Chen, Rui Shang, and Xiaheng Zhang*. C−F Bond Activation Enables Synthesis of Aryl Difluoromethyl Bicyclopentanes as Benzophenone-Type Bioisosteres. Nature Communications 2024, 15, 419.
Highlighted by J. Am. Chem. Soc. 2023, 145, 20716.
Lei Bao, Hongxiang Yang, Beibei Zhan*, and Xiaheng Zhang*. Photoinduced Bi-catalyzed C–H trifluoromethylation of (hetero)arenes. Chem Catal. 2024, 4, 100877. (invited Preview)
Shen Cao, Lu Wang, Xiaoping Chen*, and Xiaheng Zhang*. Sulfonyl Radicals Generation via β-Scission. Trends in Chemistry 2024, 6, 159. (invited highlight paper)
Hongxiang Yang, and Xiaheng Zhang*. An Efficient Strategy for the Semisynthesis of Herpes Simple Virus-1 Glycoprotein D. Chin. J. Org. Chem. 2024, 44, 326. (invited highlight paper)
2023
Lu Wang,† Minxu Shi,† Xiaoping Chen, Nicholas Su, Weili Luo, and Xiaheng Zhang*. Generation of Aromatic N-Heterocyclic Radicals for Functionalization of Unactivated Alkenes. Angew. Chem. Int. Ed. 2023, e202314312. (†co-first author)
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Olivia L. Garry, Michael Heilmann, Jingjia Chen, Yufan Liang, Xiaheng Zhang, Xiaoshen Ma, Charles S. Yeung, David Jonathan Bennett, and David W. C. MacMillan*. Rapid Access to 2-Substituted Bicyclo[1.1.1]pentanes. J. Am. Chem. Soc. 2023, 145, 3092.
2022
Siyao Wang, Qingqing Zhou, Xiaheng Zhang, Ping Wang. Site-Selective Itaconation of Complex Peptides by Photoredox Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202111388.
2020
Xiaheng Zhang†, Russell T. Smith†,Chip Le, Stefan J. McCarver, Brock T. Shireman, Nicholas I. Carruthers, and David W. C. MacMillan*. Copper-mediated Synthesis of Drug-like Bicyclopentanes. Nature 2020, 580, 220-226. (†co-first author)
2018
Yufan Liang†, Xiaheng Zhang†, and David W. C. MacMillan*. Decarboxylative sp3 C–N Coupling via Dual Copper and Photoredox Catalysis. Nature 2018, 559, 83-88. (†co-first author)
Russell T. Smith†, Xiaheng Zhang†, Juan A. Rincón*, Javier Agejas, Carlos Mateos, Mario Bar-beris, Susana García-Cerrada, Oscar de Frutos, and David W. C. MacMillan*. Metallaphotoredox-Catalyzed Cross-Electrophile Csp3–Csp3 Coupling of Aliphatic Bromides. J. Am. Chem. Soc. 2018, 140, 17433-17438. (†co-first author)
Xiaheng Zhang, and Biao Yu*. Tackling the Challenge of the Total Synthesis of Periploside A. Synlett 2018, 29, 1683-1692.
2017
Xiaheng Zhang, and David W. C. MacMillan*. Direct Aldehyde C−H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis. J. Am. Chem. Soc. 2017, 139, 11353-11356.
Xiaoping Chen, Xiaofei Shao, Wei Li, Xiaheng Zhang, and Biao Yu*. Total Synthesis of Echinoside A, a Representative Triterpene Glycoside of Sea Cucumbers. Angew. Chem. Int. Ed. 2017, 56, 7648-7652.
2016
Xiaheng Zhang, and David W. C. MacMillan*. Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3−sp2 Cross-Coupling of Oxalates with Aryl Halides. J. Am. Chem. Soc. 2016, 138, 13862-13865.
2015
Xiaheng Zhang, Yu Zhou, Jianping Zuo, and Biao Yu*. Total Synthesis of Periploside A, a Unique Pregnane Hexasaccharide with Potent Immunosuppressive Effects. Nat. Commun. 2015, 6, 5879.
You Yang*, Xiaheng Zhang, and Biao Yu*. O-Glycosylation methods in the total synthesis of complex natural glycosides. Nat. Prod. Rep. 2015, 32, 1331-1355.
Gaoyan Lian, Xiaheng Zhang, and Biao Yu*. Thioglycosides in carbohydrate research. Carbohydr. Res. 2015, 403, 13-22.
2009
Liuqing Yang, Lijian Zhong, Kazuhiro Yamato, Xiaheng Zhang, Wen Feng, Pengchi Deng, Lihua Yuan*, Xiao Cheng Zeng*, and Bing Gong*. Aromatic oligoamide macrocycles from the bimolecular coupling of folded oligomeric precursors. New J. Chem. 2009, 33, 729–733.