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成果及论文

2024年

Boyi Zhang,† Hui Bai,† Beibei Zhan,†* Kaihang Wei, Shenyou Nie*, Xiaheng Zhang*.  Deacylative arylation and alkynylation of unstrained ketones. Science Advances 2024, in press. (co-first author)


Mingshuo Chen, Yuang Cui, Xiaoping Chen, Rui Shang, and Xiaheng Zhang*. C−F Bond Activation Enables Synthesis of Aryl Difluoromethyl Bicyclopentanes as Benzophenone-Type Bioisosteres. Nature Communications 2024, 15, 419.

Highlighted by J. Am. Chem. Soc. 2023145, 20716. 


Lei Bao, Hongxiang Yang, Beibei Zhan*, and Xiaheng Zhang*. Photoinduced Bi-catalyzed C–H trifluoromethylation of (hetero)arenes. Chem Catal. 20244, 100877. (invited Preview)

For the original work by Cornella group see J. Am. Chem. Soc. 2023145, 25538.


Shen Cao, Lu Wang, Xiaoping Chen*, and Xiaheng Zhang*. Sulfonyl Radicals Generation via β-ScissionTrends in Chemistry 2024, 6, 159. (invited highlight paper)

For the original work by Hong group see J. Am. Chem. Soc. 2023145, 14510.


Hongxiang Yang, and Xiaheng Zhang*. An Efficient Strategy for the Semisynthesis of Herpes Simple Virus-1 Glycoprotein D. Chin. J. Org. Chem. 2024, 44, 326. (invited highlight paper)

For the original work by Wang group see J. Am. Chem. Soc. 2024146, 2615.


2023年

Lu Wang,† Minxu Shi,† Xiaoping Chen, Nicholas Su, Weili Luo, and Xiaheng Zhang*. Generation of Aromatic N-Heterocyclic Radicals for Functionalization of Unactivated Alkenes. Angew. Chem. Int. Ed. 2023e202314312. (co-first author)

• Highlighted by Chem

 Highlighted by WileyChem

• Highlighted by 《科学网》 

• Highlighted by 化学深耕堂  


Olivia L. Garry, Michael Heilmann, Jingjia Chen, Yufan Liang, Xiaheng Zhang, Xiaoshen Ma, Charles S. Yeung, David Jonathan Bennett, and David W. C. MacMillan*. Rapid Access to 2-Substituted Bicyclo[1.1.1]pentanes. J. Am. Chem. Soc. 2023145, 3092.



2022年

Siyao Wang, Qingqing Zhou, Xiaheng Zhang, Ping Wang. Site-Selective Itaconation of Complex Peptides by Photoredox Catalysis. Angew. Chem. Int. Ed. 202261, e202111388.



2020年

Xiaheng Zhang, Russell T. Smith,Chip Le, Stefan J. McCarver, Brock T. Shireman, Nicholas I. Carruthers, and David W. C. MacMillan*. Copper-mediated Synthesis of Drug-like Bicyclopentanes. Nature 2020, 580, 220-226. (co-first author)


2018年

 Yufan Liang, Xiaheng Zhang, and David W. C. MacMillan*. Decarboxylative sp3 C–N Coupling via Dual Copper and Photoredox Catalysis. Nature 2018, 559, 83-88. (co-first author)

Russell T. Smith, Xiaheng Zhang, Juan A. Rincón*, Javier Agejas, Carlos Mateos, Mario Bar-beris, Susana García-Cerrada, Oscar de Frutos, and David W. C. MacMillan*. Metallaphotoredox-Catalyzed Cross-Electrophile Csp3–Csp3 Coupling of Aliphatic Bromides.   J. Am. Chem. Soc. 2018, 140, 17433-17438. (co-first author)

 Xiaheng Zhang, and Biao Yu*. Tackling the Challenge of the Total Synthesis of Periploside A. Synlett 2018, 29, 1683-1692.


2017年

 Xiaheng Zhang, and David W. C. MacMillan*. Direct Aldehyde CH Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis. J. Am. Chem. Soc. 2017, 139, 11353-11356.

Xiaoping Chen, Xiaofei Shao, Wei Li, Xiaheng Zhang, and Biao Yu*. Total Synthesis of Echinoside A, a Representative Triterpene Glycoside of Sea Cucumbers. Angew. Chem. Int. Ed. 2017, 56, 7648-7652.


2016年

Xiaheng Zhang, and David W. C. MacMillan*. Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3sp2 Cross-Coupling of Oxalates with Aryl Halides. J. Am. Chem. Soc. 2016, 138, 13862-13865.


2015年

Xiaheng Zhang, Yu Zhou, Jianping Zuo, and Biao Yu*. Total Synthesis of Periploside A, a Unique Pregnane Hexasaccharide with Potent Immunosuppressive Effects. Nat. Commun2015, 6, 5879.

You Yang*, Xiaheng Zhang, and Biao Yu*. O-Glycosylation methods in the total synthesis of complex natural glycosides. Nat. Prod. Rep. 2015, 32, 1331-1355.

Gaoyan Lian, Xiaheng Zhang, and Biao Yu*. Thioglycosides in carbohydrate research. Carbohydr. Res. 2015, 403, 13-22.


2009年

Liuqing Yang, Lijian Zhong, Kazuhiro Yamato, Xiaheng Zhang, Wen Feng, Pengchi Deng, Lihua Yuan*, Xiao Cheng Zeng*, and Bing Gong*. Aromatic oligoamide macrocycles from the bimolecular coupling of folded oligomeric precursors. New J. Chem. 2009, 33, 729–733.