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成果及论文

2024

30. High Contrast Bioimaging of Tumor & Inflammation with A Bicyclic Dioxetane Chemiluminescent Probe

Shang, Qian; Li, Shen-Huan; He, Yu-Ting; Zhang, Yun; Fu, Ting; Han, Shisong; Huang, Wenshan; Wang, Xue-Qiang*;  Xu, Jie-Hua*

Analytical Chemistry, 2024, 96, 2286–2291. DOI: 10.1021/acs.analchem.3c05062

Link: https://doi.org/10.1021/acs.analchem.3c05062


2023

29. Emission Wavelength-Tunable Bicyclic Dioxetane Chemiluminescent Probes for Precise in vitro and in vivo Imaging

Li, Shen-Huan; Zhang, Guo-Rong; He, Yu-Ting; Yang, Liu; Li, Han-Lu; Long, Cheng-Yu; Cui, Yue; Wang, Xue-Qiang*

Analytical Chemistry, 2023, 95, 13191–13200.

Link: https://doi.org/10.1021/acs.analchem.3c02126


28. Chemical Tailoring of Aptamer Glues with Significantly Enhanced Recognition Ability for Targeted Membrane Protein Degradation

Zhang, Guo-Rong; Tan, Weihong; Wang, Xue-Qiang*

ACS Nano, 2023, 17, 15146-15154. DOI: 10.1021/acsnano.3c04457

Link: https://pubs.acs.org/doi/full/10.1021/acsnano.3c04457


27. Ni-Catalyzed Protecting Group-Free Diphenic Acid Analogs Synthesis

Bo-Wei Zhao, Liu Yang, Cheng-Yu Long,Han-Lu Li, Yu-Ting He, Xue-Qiang Wang*

Organic Letters, 2023,  25, 4700–4704. DOI:10.1021/acs.orglett.3c01625

Link:https://doi.org/10.1021/acs.orglett.3c01625


26. Regulating the Properties of XQ-2d for Targeted Therapeutic Agents Delivery to Pancreatic Cancer

Qiuxia Yang, Yongbo Peng, Zhengyu Deng, Dailiang Zhang, Cheng-Yu Long, Guo-Rong Zhang, Juan Li, Xue-Qiang Wang*,  Weihong Tan*

National Science Review, 2023, online. DOI:10.1093/nsr/nwad113

Link: https://doi.org/10.1093/nsr/nwad113


25. A Versatile Strategy for Convenient Circular Bivalent Functional Nucleic Acids Construction
Xiao-Jing Zhang, Zhuo Zhao, Xia Wang, Min-Hui Su, Yingying Li, Quan Yuan, Xue-Qiang Wang*, Weihong Tan

National Science Review, 2023, 10, nwac107

Link:https://academic.oup.com/nsr/article/10/2/nwac107/6603820


2022:

24. Dual-Targeting Circular Aptamer Strategy Enabled Recognition of Dfferent Leukemia Cells with Enhanced Binding Ability

Lili Ai#, Tianhuan Peng#, Yingying Li, Hailan Kuai, Yingyu Sima, Minhui Su, Dan Wang, Qiuxia Yang, Xue-Qiang Wang*, Weihong Tan*

Angew. Chem. Int. Ed, 2022, 61, e202109500. DOI: 10.1002/anie.202109500

Link:https://doi.org/10.1002/anie.202109500


23. CsOH-Promoted Regiospecific C-H Chalcogenation of Indoles in H2O

Shitang Xu, Rongnan Yi, Chunling Zeng, Yue Cui, Xue-Qiang Wang*, Xinhua Xua, Ningbo Li*

Synlett, 2022, accepted, DOI: 10.1055/a-1879-2521 (invited letter)

Link:https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1879-2521


22. Highly Chemoselective Ni-Catalyzed Protecting-Group-Free 2,2'-Biphenols Synthesis and Mechanistic Insights

Cheng-Yu Long, Hao Chen, Cheng Ma, Bo-Wei Zhao, Shen-Huan Li, Yue Cui, Xinge Yang,*, Shao-Fei Ni*, Xue-Qiang Wang*

Organic Letters2022, 24, 4155–4159. DOI: 10.1021/acs.orglett.2c01367

Link: https://pubs.acs.org/doi/abs/10.1021/acs.orglett.2c01367


21. Molecularly Engineered  Aptamers Targeting Tumor Tissue and Cancer Cells for Efficient in vivo Recognition and Enrichment

Xia Wang, Xiao-Jing Zhang, Yingying Li, Guo-Rong Zhang, Juan Li, Xue-Qiang Wang*, Weihong Tan

CCS Chemistry, 2022, 4, 2581–2587. DOI: 10.31635/ccschem.021.202101337

Link: https://doi.org/10.31635/ccschem.021.202101337


2021:

20. Recent Progresses in Amination Enabled by Transition-Metal-Free C(sp2)-O/C(sp2)-S Bond Cleavage Strategy

Shen-Huan Li, Cheng-Yu Long, Xin-Ge Yang*, Xue-Qiang Wang*

Synthesis 2021, 53, 3716. (Invited Review) DOI: 10.1055/s-0040-1720382

Link: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0040-1720382


19. Regulating the Anticancer Efficacy of Sgc8-Combretastatin A4 Conjugates: A Case of Recognizing the Significance of Linker Chemistry for the Design of Aptamer-Based Targeted Drug Delivery Strategies

Zhiyong Huang, Dan Wang, Cheng-Yu Long, Shen-Huan Li, Xue-Qiang Wang*, Weihong Tan*

J. Am. Chem. Soc. 2021, 143, 8559–8564. DOI: 10.1021/jacs.1c03013

Link: https://pubs.acs.org/doi/10.1021/jacs.1c03013


18.  A New Paradigm for Artesunate Anticancer FunctionConsiderably Enhancing the Cytotoxicity via Conjugating Artesunate with Aptamer
Li Yingying, Peng Yongbo, Tan Yan, Xuan Wenjing, Fu Ting, Xue-Qiang Wang*, Weihong Tan*

Signal Transduction and Targeted Therapy, 2021, 6, 327. DOI: 10.1038/s41392-021-00671-8

Link: https://www.nature.com/articles/s41392-021-00671-8


17.  Aptamer-Peptide Conjugates as Targeted Chemosensitizers for Breast Cancer Treatment

Yan Tan, Yingying Li, Yi-Xin Qu, Yuanye Su, Yongbo Peng, Zilong Zhao, Ting Fu, Xue-Qiang Wang*, Weihong Tan*

ACS Applied Materials & Interfaces, 2021, 13, 8, 9436–9444. DOI: 10.1021/acsami.0c18282.

Link: https://pubs.acs.org/doi/abs/10.1021/acsami.0c18282


16Nucleophilic Etherification of Heteroaryl Alkyl Ethers, Heteroaryl Halides with (Deuterated)Alcohols

Wang, Xia# Qu, Yixin#  Long, Chengyu Wang, Xue-Qiang*

Chinese Journal of Organic Chemistry, 2021, 41, 2, 795-805. DOI: 10.6023/cjoc202006077.

Link: http://sioc-journal.cn/Jwk_yjhx/EN/10.6023/cjoc202006077


2020:

15.  Hierarchical Fabrication of DNA Wireframe Nanoarchitectures for Efficient Cancer Imaging and Targeted Therapy

Dan Wang, Ruizi Peng, Yongbo Peng, Zhengyu Deng, Fengyuan Xu, Yuanye Su, Pengfei Wang, Ling Li, Xue-Qiang Wang*, Yonggang Ke*, Weihong Tan*

ACS Nano, 2020, 14, 17365–17375.

Link: https://pubs.acs.org/doi/abs/10.1021/acsnano.0c07495


14.  Highly Chemoselective Access to 2,2'-Diaminobiaryls via Ni-Catalyzed Protecting-Group-Free Coupling of 2-Haloanilines

Cheng-Yu Long#, Shaofei Ni#, Min-Hui Su#, Xue-Qiang Wang*, Weihong Tan

ACS Catalysis, 2020, 10, 13641–13649

Link:https://pubs.acs.org/doi/10.1021/acscatal.0c03428


13 Modularly Engineered Solid‐Phase Synthesis of Aptamer‐Functionalized Small Molecule Drugs for Targeted Cancer Therapy

Dan Wang,# Yongbo Peng,# Zhengyu Deng,# Yan Tan, Yuanye Su, Hailan Kuai, Lili Ai, Zhiyong Huang, Xue-Qiang Wang*, Xiaobing Zhang*, and Weihong Tan*

Advanced Therapeutics, 2020, 202000074

Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.202000074


12. Aptamer Enables Consistent Maytansine Delivery Through Maintaining Receptor Homeostasis for HER2 Targeted Cancer Therapy

Yan Tan, Yongbo Peng, Lili Ai, Yingying Li, Yixin Qu, Dan Wang, Yuanye Su, Tanggang Deng, Ting Fu, Zilong Zhao, Xue-Qiang Wang*, and Weihong Tan*

Bioconjugate Chem. 2020, 31, 7, 1766–1774

Link: https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.0c00250


11. Targeted delivery of emodin to adipocytes by aptamer-functionalized PEG-PLGA nanoparticles in vitro

Bo Yu,Ying Pu,Jun Liu,Jie Liao,Ke Chen,Jiani Zhang,Wen Zhong,Yalan Hu,Xue-Qiang  Wang*, Bo Liu*, Huixia Liu*, Weihong Tan

J. Drug Deliv. Sci. Technol., 2020, 57, DOI: 10.1016/j.jddst.2020.101739

Link: https://www.sciencedirect.com/science/article/pii/S1773224719319112


10. Conjugating Aptamer and Mitomycin C with Reductant-Responsive Linker Leading to Synergistically Enhanced Anticancer Effect

Qiuxia Yang, Zhengyu Deng, Dan Wang, Jiaxuan He, Dailiang Zhang, Yan Tan, Tianhuan Peng Xue-Qiang Wang*, Weihong Tan*

J. Am. Chem. Soc. 2020,  142, 2532-2540

Link: https://pubs.acs.org/doi/10.1021/jacs.9b12409


9. Molecularly Engineering Triptolide with Aptamers for High Specificity and Cytotoxicity for Triple-Negative Breast Cancer

Jiaxuan He, Tianhuan Peng, Yongbo Peng, Lili Ai, Zhengyu Deng, Xue-Qiang Wang*, Weihong Tan*

J. Am. Chem. Soc. 2020, 142, 6, 2699–2703

Link: https://pubs.acs.org/doi/10.1021/jacs.9b10510

                                 

                                 

           

           

           

           

                                 

                                 

           

                                 

           

           

           

                                 

           

           

                                 

           

           

           

           

           

                       
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8. Polymeric Engineering of Aptamer–Drug Conjugates for Targeted Cancer Therapy

Zhengyu Deng, Qiuxia Yang, Yongbo Peng, Jiaxuan He, Shujuan Xu, Dan Wang, Tianhuan Peng, Ruowen Wang, Xue-Qiang Wang*, Weihong Tan*

Bioconjugate Chem. 2020, 31, 37-42

Link: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00715


7. Functional nucleic acids for cancer theranostics

Tianhuan Peng, Zhengyu Deng, Jiaxuan He, Yingying Li, Yan Tan, Yongbo Peng, Xue-Qiang Wang*,Weihong Tan*

Coordination Chemistry Reviews, 2020, 43, 213080

Link: https://www.sciencedirect.com/science/article/pii/S0010854519304692


2019:

6. Deuterated Aryl Alkyl Ethers Synthesis via Nucleophilic Etherification of Aryl Alkyl Ethers and Thioethers with Deuterated Alcohols

Shuai Li, Xia Wang, Xinge Yang*, Guiquan Yu, Xue-Qiang Wang*

Synlett 2019, 30, 1805-1809

Link: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1611898


5. Rapid Amination of Methoxy Pyridines with Aliphatic Amines

Xia Wang,Cheng-Yu Long,Min-Hui Su,Yi-Xin Qu,Shen-Huan Li,Xiao-Jing Zhang,Xue-Qiang Wang*

Org. Process Res. Dev. 201923,1587-1593 (Invited paper)

Link: https://pubs.acs.org/doi/10.1021/acs.oprd.9b00235


4. Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines

Xia Wang, Qiu-Xia Yang, Cheng-Yu Long, Yan Tan, Yi-Xin Qu, Min-Hui Su, Weihong Tan*, Xue-Qiang Wang*

Org. Lett. 2019, 21, 5111-5115

Link: https://pubs.acs.org/doi/full/10.1021/acs.orglett.9b01711


2018:

3. Nucleophilic Amination and Etherification of Aryl Alkyl Thioethers

Xia Wang, Yue Tang, Cheng-Yu Long, Wen-Ke Dong, Chenchen Li, Xinhua Xu, Wanxiang Zhao,* Xue-Qiang Wang*

Org. Lett. 2018, 20, 4749–4753. Highlighted by Synfacts 2018, 14(10), 1076

Link: https://pubs.acs.org/doi/10.1021/acs.orglett.8b01758


2. Metal-Free Etherification of Aryl Methyl Ether Derivatives by C-OMe Bond Cleavage

Xue-Qiang Wang,* Chenchen Li, Xia Wang, Qingli Wang, Xiu-Qin Dong, Abing Duan,* Wanxiang Zhao*
Org. Lett. 2018, 20, 4267–4272

Link: https://pubs.acs.org/doi/abs/10.1021/acs.orglett.8b01696


1. NaI-mediated Divergent Synthesis of Isatins and Isoindigoes: A New Protocol Enabled by Oxidation Relay Strategy
Hong-hua Zhang, Yong-qiang Wang, Long-tao Huang, Long-qing Zhu, Yi-yue Feng, Yingmei Lu, Quan-yi Zhao,
Xue-Qiang Wang,* Zhen Wang *

Chem. Commun., 2018, 54, 8265-8268

Link: https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc04471f#!divAbstract