代表性论文

1.   Fan Yang, Duo Zhang, Haowen Jiang, Jiangbin Ye, Lin Zhang, Stephen J. Bagley, Jeffery Winkler, Yanqing Gong, and Yi Fan. Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science Translational Medicine. 2023 Feb 15;15(683):eabq3558. (https://pmc.ncbi.nlm.nih.gov/articles/PMC10394757IF: 15.8 Q1 B1/)

2.   Fan Yang^#, Md Naushad Akhtar^#, Duo Zhang, Rakan El-Mayta, Junyoung Shin, Jay F Dorsey, Lin Zhang, Xiaowei Xu, Wei Guo, Stephen J Bagley, Serge Y Fuchs, Constantinos Koumenis 1, Justin D Lathia, Michael J Mitchell, Yanqing Gong, Yi Fan. An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science Advances. 2024 Mar;10(9):eadj4678. (https://pmc.ncbi.nlm.nih.gov/articles/PMC10901371IF: 11.7 Q1 B1/)

3.   Fan Yang^#, Zhengqiang He^#, Hao Duan^#, Duo Zhang, Juehui Li, Huijuan Yang, Jay F Dorsey, Wei Zou, S Ali Nabavizadeh, Stephen J Bagley, Kalil Abdullah, Steven Brem, Lin Zhang, Xiaowei Xu, Katelyn T Byrne, Robert H Vonderheide, Yanqing Gong, Yi Fan. Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nat Commun. 2021 Jun 8;12(1):3424.(https://pmc.ncbi.nlm.nih.gov/articles/PMC8187342IF: 14.7 Q1 B1/)

4.   Aizhen Xiong, Jiwei Zhang, Yan Chen, Yi Zhang, Fan Yang. Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM. eBioMedicine. 2022 Sep; 83:104239. (https://pmc.ncbi.nlm.nih.gov/articles/PMC9437813IF: 9.7 Q1 B1/)

5.   Fan Yang, Gloria Lee, Yi Fan. Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism. Angiogenesis. 2024 Aug;27(3):333-349. (https://pmc.ncbi.nlm.nih.gov/articles/PMC11303583IF: 9.2 Q1 B1/)

6.   Menggui Huang^#, Fan Yang^#, Duo Zhang^#, Maohuan Lin, Hao Duan, Rakan El-Mayta, Lin Zhang, Ling Qin, Swapnil V. Shewale, Liming Pei, Michael J. Mitchell, Yi Fan and Yanqing Gong. Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nature Cardiovascular Research. 2022 Apr;1(4):372-388.  (https://pmc.ncbi.nlm.nih.gov/articles/PMC9104847IF: 9.4 Q1 NA/)

7.   Wenjuan Ma^#, Yanling Wang^#, Rongxin Zhang^#, Fan Yang^#, Duo Zhang, Menggui Huang, Lin Zhang, Jay F. Dorsey, Zev A. Binder, Donald M. O’Rourke, Joseph A. Fraietta, Yanqing Gong, Yi Fan. Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer.2021; 2(1):83-97. (https://pmc.ncbi.nlm.nih.gov/articles/PMC10097424IF: 23.5 Q1 B1/)