Publications
2026
68. In revision
67. In revision
66. Pan, X.;# Li, H.;# Dong, L.-B.*, Engineering class I terpene synthases for skeletal diversity: strategies and applications. Nat. Prod. Rep. 2026, in press. DOI: 10.1039/D5NP00066A.
2025
65. Sun, X.;# Li, F.-R.;# Yang, Q.; Pan, X.; Xu, H.-M.; Dong, L.-B.*, Discovery and characterization of a cis-casbene diterpene synthase from Streptomyces paromomycinus. J. Nat. Prod. 2025, 88, 2481-2489. DOI: 10.1021/acs.jnatprod.5c00870. Link
64. Lin, X.;# Xu, X.;# Zhang, D.; Chen, S.; Pan, X.; Wang, Z.; Xu, H.-M.; Dong, L.-B*, Engineering Streptomyces for efficient terpenoid production. J. Agri. Food Chem. 2025, 73, 22039-22045. DOI: 10.1021/acs.jafc.5c08127. Link
63. Yang, Z.;# Pan, X.;# Deng, L.; Wang, Z.; Li, F.-R.; Lin, X.; Xu, H.-M.; Dong, L.-B.*, Genome mining reveals a highly oxidized bacterial perhydrophenanthrene meroterpenoid smelanic acid. Org. Biomol. Chem., 2025, 23, 7773-7779. DOI: 10.1039/D5OB01195G. Link
62. Yue, M.; Deng, L.; Lin, X.; Dong, L.-B.*, Development and advances of CRISPR/Cas technology in Streptomyces. Chin. J. Antibiot. 2025, 50, 572-584. (invited review) Link
61. Li, F.-R.;# Yang, Q.;# He, J.;# Sun, X.; Pan, X.; Xu, H.-M.; Rudolf, J. D.; Dong, L.-B.*, Crystal structure and catalytic mechanism of the cis-eunicellane cyclase AriE. Chem. Eur. J. 2025, 31, e202500012. DOI: https://doi.org/10.1002/chem.202500012. Link
60. Du, W.;# Cheng, Z.;# Pan, X.;# Liu, C.; Yue, M.; Li, T.; Xiao, Z.; Li, L.-L.; Zeng, X.; Lin, X.; Li, F.;* Dong, L.-B.*, Microbe engineering to provide drimane-type building blocks for chiral pool synthesis of meroterpenoids. Angew. Chem. Int. Ed. 2025, 64, e202419463. DOI: https://doi.org/10.1002/anie.202419463. Link
59. Wang, Z.; Alsup, T. A.; Pan, X.; Li, L.; Tian, J.; Yang, Z.; Lin, X.; Xu, H.-M.; Rudolf, J. D.; Dong, L.-B.*, Biosynthesis of a bacterial meroterpenoid reveals a non-canonical class II terpene synthase. Chem. Sci., 2025, 16, 310-317. DOI: 10.1039/D4SC06010E. Link
2024
58. Li, F.-R.;# Wang, Q.;# Pan, X.; Xu, H.-M.; Dong, L.-B.*, Discovery, structure, and engineering of a cis-geranylfarnesyl diphosphate synthase. Angew. Chem. Int. Ed. 2024, 63, e202401669. Link
57. Alsup, T.; Li, Z.; McCadden, C.; Jagels, A.; Łomowska-Keehner, D.; Marshall, E.; Dong, L.-B.; Loesgen, S.; Rudolf, J.*, Early-stage biosynthesis of phenalinolactone diterpenoids involves sequential prenylation, epoxidation, and cyclization. RSC Chem. Biol. 2024. 5, 1010-1016. Link
56. Zhang, D.; Du, W.; Pan, X.; Lin, X.; Li, F.-R.; Wang, Q.; Yang, Q.; Xu, H.-M.; Dong, L.-B.*, Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus. Beilstein J. Org. Chem., 2024, 20, 815-822. Link
55. Yang, Q.;# Tian, J.;# Chen, S.;# Yang, Z.; Wang, Z.; Xu, H.-M.; Dong, L.-B.*, Discovery of sesquiterpenoids from an actinomycete Crossiella cryophila through genome mining and heterologous expression. Bioorg. Chem. 2024, 146, 107308. Link
54. Pan, X.; Dong, L.-B.*, Deciphering magnesium binding site and structure-function insights in a class II sesquiterpene cyclase. Methods Enzymol. 2024, 699, 25-57. Link
53. Xiao, Z.;# Yang, Q.;# Lin, X.;# Li, F.-R.; Zhang, X.; Xu, H.-M.; Wang, Z.; Wang, J.; Dong, L.-B.*, Cytochrome P450-mediated skeleton rearrangement of taxadiene in an engineered Escherichia coli system. Org. Lett. 2024. 26, 1640-1644. Link
52. Fluegel, L. L.; Deng, M.-R.; Su, P.; Kalkreuter, E.; Yang, D.; Rudolf, J. D.; Dong, L.-B.; Shen, B.*, Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. J. Ind. Microbiol. Biotechnol. 2024, kuae003. Link
51. Chen, S.;# Yang, Q.;# Zhang, X.; Wang, Z.; Xu, H.-M.; Dong, L.-B.*, Discovery of diverse sesquiterpenoids from Crossiella cryophila through genome mining and NMR tracking. J. Nat. Prod. 2024, 87, 195-206. Link
50. Pan, X.; Rudolf, J. D.;* Dong, L.-B.*, Class II terpene cyclases: structures, mechanisms, and engineering. Nat. Prod. Rep. 2024, 41, 402-433. Link
2023
49. Xu, Z. F.; Dong, L.-B.* De novo production of 24-epi-ergosterol in bioengineered yeast. Chin. J. Nat. Med., 2023, 21, 321-322 (Comment). link
48. Wang, Z.;# Yang, Q.;#,* He, J.; Li, H.; Pan, X.; Li, Z.; Xu, H.-M.; Rudolf, J. D.; Tantillo, D. J.;* Dong, L.-B.* Cytochrome P450 mediated cyclization in eunicellane derived diterpenoid biosynthesis. Angew. Chem. Int. Ed. 2023, 62, e202312490. DOI: 10.1002/anie.202312490. link
2022
47. Pan X.;# Du W.;# Zhang X.; Lin X.; Li F.-R.; Yang Q.; Wang H.; Rudolf, J. D.;*, Zhang B.;* Dong L.-B.*, Discovery, structure, and mechanism of a class II sesquiterpene cyclase. J. Am. Chem. Soc. 2022, 144, 22067-22074. link
46. Li F.-R.; Lin X.; Yang Q.; Tan N.-H.; Dong L.-B.*, Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli. Beilstein J. Org. Chem., 2022, 18, 881-888. (invited article for a thematic issue of "Enzyme in biosynthesis") link
45. Du W;# Yang Q;# Xu H.-M.; Dong L.-B.*, Drimane-type sesquiterpenoids from fungi. Chin. J. Nat. Med., 2022, 20, 737-748. (invited review) link
2021
44. Luo J.;# Yang D.;# Adhikari A.;# Dong L.-B.; Ye F.; Yan X.; Rader C.; Shen B.*, Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis. J. Ind. Microbiol. Biotechnol., 2021, DOI: 10.1093/jimb/kuab027. link
2020
43. Zheng C.-J.;# Kalkreuter E.;# Fan B.-Y.; Liu Y.-C.; Dong L.-B.; Shen B.*. PtmC catalyzes the final step of thioplatensimycin, thioplatencin, and thioplatensilin biosynthesis and expands the scope of arylamine N-acetyltransferases. ACS Chem. Biol., 2020, 16, 96-105. link
42. Zhang, X.; King-Smith, E.; Dong, L. B.; Yang, L. C.; Rudolf, J. D.; Shen, B.; Renata, H.*, Divergent synthesis of complex diterpenes through a hybrid oxidative approach. Science 2020, 369, 799-806. link
41. Yi, S.;# Kuang, T.;# Miao, Y.; Xu, Y.; Wang, Z.; Dong, L.-B.; Tan, N.*, Discovery and characterization of four glycosyltransferases involved in anthraquinone glycoside biosynthesis in Rubia yunnanensis. Org. Chem. Front. 2020, 7, 2442-2448. link
2019
40. Dong, L.-B.;# Liu, Y.-C.;# Cepeda, A. J.; Kalkreuter, E.; Deng, M.-R.; Rudolf, J. D.; Chang, C.; Joachimiak, A.; Phillips, G. N.; Shen, B.*, Characterization and crystal structure of a nonheme diiron monooxygenase involved in platensimycin and platencin biosynthesis. J. Am. Chem. Soc. 2019, 141, 12406-12412. link
39. Dong, L.-B.;# Zhang, X.;# Rudolf, J. D.; Deng, M.-R.; Kalkreuter, E.; Cepeda, A. J.; Renata, H.; Shen, B.*, Cryptic and stereospecific hydroxylation, oxidation, and reduction in platensimycin and platencin biosynthesis. J. Am. Chem. Soc. 2019, 141, 4043-4050. link
38. Meng Su, M.; Qiu, L.; Deng, Y.; Ruiz, C. H.; Rudolf, J. D.; Dong, L.-B.; Feng, X.; Cameron, M. D.; Shen, B.; Duan, Y.*; and Huang, Y.*, Evaluation of platensimycin and platensimycin-inspired thioether analogues against methicillin-resistant Staphylococcus aureus in topical and systemic infection mouse model. Mol Pharmaceutics, 2019, 16, 3065-3071. link
37. Zhu, Y.; Dong, L.-B.; Zhang, Z.-J.; Fan, M.; Zhu, Q.-F.; Qi, Y.-Y.; Liu, Y.-C.; Peng, L.-Y.; Wu, X.-D.; Zhao, Q.-S.*, Three new Lycopodium alkaloids from Lycopodium japonicum. J. Asian Nat. Prod. Res. 2019, 21, 17-24. link
2018
36. Dong, L.-B.; Rudolf, J. D.; Kang, D.; Wang, N.; He, C. Q.; Deng, Y.; Huang, Y.; Houk, K. N.; Duan, Y.; Shen, B.*, Biosynthesis of thiocarboxylic acid-containing natural products. Nat. Commun. 2018, 9, 2362.
**Paper highlighted by EurekAlert, AAAS: “Scientists find potential disease-fighting 'warheads' hidden in bacteria”, Public Release: 18-June-2018**Paper selected as the 50 most read Nature Communications chemistry and materials science articles published in 2018. link
35. Dong, L.-B.;# Rudolf, J. D.;# Deng, M.-R.; Yan, X.-H.; Shen, B.*, Discovery of the tiancilactone antibiotics by genome mining of atypical bacterial type II diterpene synthases. ChemBioChem 2018, 19, 1727-1733. link
34. Rudolf, J. D.; Dong, L.-B.; Zhang, X.; Renata, H.; Shen, B.*, Cytochrome P450-catalyzed hydroxylation initiating ether formation in platensimycin biosynthesis. J. Am. Chem. Soc. 2018, 140, 12349-12353. link
33. Wang, N.;# Rudolf, J. D.;# Dong, L.-B.; Osipiuk, J.; Hatzos-Skintges, C.; Endres, M.; Chang, C.-Y.; Babnigg, G.; Joachimiak, A.; Phillips, G. N. Jr.; Shen, B.*, Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nat. Chem. Biol. 2018, 14, 730-737. link
32. Yang, D;# Hindra;# Dong, L.-B.; Crnovčić, I.; Shen, B.*, Engineered production and evaluation of 6′-deoxy-tallysomycin H-1 revealing new insights into the structure–activity relationship of the anticancer drug bleomycin. J. Antibiot. 2018, 71, 97-103. link
31. Crnovcic, I.; Gan, F.; Yang, D.; Dong, L.-B.; Schultz, P. G.; Shen, B., Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. Bioorg. Med. Chem. Lett. 2018, 16, 2670-2674. link
2017
30. Dong, L.-B.;# Rudolf, J. D.;# Lin, L.; Ruiz, C.; Cameron, M. D.;* Shen, B.*, In vivo instability of platensimycin and platencin: synthesis and biological evaluation of urea- and carbamate-platensimycin. Bioorg. Med. Chem. 2017, 25, 1990-1996. link
29. Rudolf, J. D.; Dong, L.-B.; Shen, B.*, Platensimycin and platencin: inspirations for chemistry, biology, enzymology, and medicine. Biochem. Pharmacol. 2017, 133, 139-151. link
28. Hindra;# Yang, D.;# Teng, Q.; Dong, L.-B.; Crnovčić, I.; Huang, T.; Ge, H.; Shen, B.*, Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues. Org. Lett. 2017, 19, 1386-1389. link
2016
27. Rudolf, J. D.;# Dong, L.-B.;# Manoogian, K.; Shen, B.*, Biosynthetic origin of the ether ring in platensimycin. J. Am. Chem. Soc. 2016, 138, 16711-16721. link
26. Rudolf, J. D.;# Dong, L.-B.;# Cao, H.; Hatzos-Skintges, C.; Osipiuk, J.; Endres, M.; Chang, C.-Y.; Ma, M.; Babnigg, G.; Joachimiak, A.; Phillips, G. N.; Shen, B.*, Structure of the ent-copalyl diphosphate synthase PtmT2 from Streptomyces platensis CB00739, a bacterial type II diterpene synthase. J. Am. Chem. Soc. 2016, 138, 10905-10915.
**Paper highlighted by EurekAlert, AAAS: “'Missing Evolutionary Link' of a Widely Used Natural Drug Source”, Public Release: 19-AUG-2016. link
25. Dong, L.-B.;# Rudolf, J. D.;# Shen, B.*, A mutasynthetic library of platensimycin and platencin analogues. Org. Lett. 2016, 18, 4606-4609. link
24. Dong, L.-B.; Wu, X.-D.; Shi, X.; Zhang, Z.-J.; Yang, J.; Zhao, Q.-S.*, Phleghenrines A–D and neophleghenrine A, bioactive and structurally rigid Lycopodium alkaloids from Phlegmariurus henryi. Org. Lett. 2016, 18, 4498-4501.
**Paper highlighted by the “Hot off the Press” of Natural Product Reports (Hill, R. A.; Sutherland, A., Nat. Prod. Rep. 2016, 33, 1352-1356). link
23. Dong, L.-B.;# Rudolf, J. D.;# Shen, B.*, Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. Bioorg. Med. Chem. 2016, 24, 6348-6353. link
2015
22. Rudolf, J. D.;# Dong, L.-B.;# Huang, T.; Shen, B.*, A genetically amenable platensimycin-and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Mol. BioSyst. 2015, 11, 2717-2726.
**This paper is part of themed collection: 10th Anniversary of Molecular BioSystems and 2015 Hot Articles in Molecular BioSystems, and printed on the front cover. link
21. Peng, L.-Y.; Xu, G.; He, J.; Wu, X.-D.; Dong, L.-B.; Gao, X.; Cheng, X.; Su, J.; Li, Y.; Dong, W.-M.; Zhao, Q.-S.*, Nor-lupane triterpenoid and guaiane sesquiterpenoids from Schefflera venulosa. Fitoterapia 2015, 103, 294-298. link
2014
20. Dong, L.-B.; Wu, Y.-N.; Jiang, S.-Z.; Wu, X.-D.; He, J.; Yang, Y.-R.;* Zhao, Q.-S.*, Isolation and complete structural assignment of Lycopodium alkaloid cernupalhine A: theoretical prediction and total synthesis validation. Org. Lett. 2014, 16, 2700-2703.
**Paper highlighted by the “Hot off the Press” of Natural Product Reports (Hill, R. A.; Sutherland, A., Nat. Prod. Rep. 2014, 31, 1083-1087). link
19. Liu, F.; Dong, L.-B.; Gao, X.; Wu, X.-D.; He, J.; Peng, L.-Y.; Cheng, X.; Zhao, Q.-S.*, New Lycopodium alkaloids from Phlegmariurus squarrosus. J. Asian Nat. Prod. Res. 2014, 16, 574-580. link
18. Gao, X.; Shao, L.-D.; Dong, L.-B.; Cheng, X.; Wu, X.-D.; Liu, F.; Jiang, W.-W.; Peng, L.-Y.; He, J.*; Zhao, Q.-S.*, Vibsatins A and B, Two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. variegatus. Org. Lett. 2014, 16, 980-983. link
2013
17. Dong, L.-B.; Gao, X.; Liu, F.; He, J.; Wu, X.-D.; Li, Y.; Zhao, Q.-S.*, Isopalhinine A, a unique pentacyclic Lycopodium alkaloid from Palhinhaea cernua. Org. Lett. 2013, 15, 3570-3573. link
16. Li, Y.-P.; Dong, L.-B.; Chen, D.-Z.; Li, H.-M.; Zhong, J.-D.; Li, F.; Liu, X.; Wang, B.; Li, R.-T.*, Two new dihydrobenzofuran-type neolignans from Breynia fruticosa. Phytochem. Lett. 2013, 6, 281-285. link
15. Zhang, X.-Y.; Dong, L.-B.; Liu, F.; Wu, X.-D.; He, J.; Peng, L.-Y.; Luo, H.-R.; Zhao, Q.-S.*, New Lycopodium alkaloids from Lycopodium obscurum. Nat. Prod. Bioprospect. 2013, 3, 52-55. link
14. Wu, X.-D.; He, J.; Li, X.-Y.; Dong, L.-B.; Gong, X.; Song, L.-D.; Li, Y.; Peng, L.-Y.; Zhao, Q.-S.*, Diterpenoids from the Twigs and Leaves of Fokienia hodginsii. J. Nat. Prod. 2013, 76, 1032-1038. link
13. Wu, X.-D.; Wang, L.; He, J.; Li, X.-Y.; Dong, L.-B.; Gong, X.; Gao, X.; Song, L.-D.; Li, Y.; Peng, L.-Y.; Zhao, Q.-S.*, Two new indole alkaloids from Emmenopterys henryi. Helv. Chim. Acta 2013, 96, 2207-2213. link
12. Wu, X.-D.; He, J.; Li, X.-Y.; Dong, L.-B.; Gong, X.; Gao, X.; Song, L.-D.; Li, Y.; Peng, L.-Y.; Zhao, Q.-S.*, Triterpenoids and steroids with cytotoxic activity from Emmenopterys henryi. Planta Med. 2013, 79, 1356-1361. link
11. Cheng, J.-T.; Liu, F.; Li, X.-N.; Wu, X.-D.; Dong, L.-B.; Peng, L.-Y.; Huang, S.-X.; He, J.*; Zhao, Q.-S.*, Lycospidine A, a new type of Lycopodium alkaloid from Lycopodium complanatum. Org. Lett. 2013, 15, 2438-2441. link
10. Cheng, J. T.; Han, Y. Q.; He, J.; De, W. X.; Dong, L.-B.; Peng, L. Y.; Li, Y.; Zhao, Q. S.*, Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis. Arch. Pharmacal Res. 2013, 36, 1084-1089. link
9. Gao, X.; He, J.; Wu, X.-D.; Peng, L.-Y.; Dong, L.-B.; Deng, X.; Li, Y.; Cheng, X.; Zhao, Q.-S.*, Further lignans from Saururus chinensis. Planta Med. 2013, 79, 1720-1723. link
8. Wu, X.-D.; Zhang, L.-C.; He, J.; Li, G.-T.; Ding, L.-F.; Gao, X.; Dong, L.-B.; Song, L.-D.; Li, Y.; Zhao, Q.-S.*, Two new diterpenoids from Excoecaria acerifolia. J. Asian Nat. Prod. Res. 2013, 15, 151-157. link
7. Wu, X.-D.; Wang, S.-Y.; Wang, L.; He, J.; Li, G.-T.; Ding, L.-F.; Gong, X.; Dong, L.-B.; Song, L.-D.; Li, Y.; Zhao, Q.-S.*, Labdane diterpenoids and lignans from Calocedrus macrolepis. Fitoterapia 2013, 85, 154-160. link
2012
6. Dong, L.-B.; Yang, J.; He, J.; Luo, H.-R.; Wu, X.-D.; Deng, X.; Peng, L.-Y.; Cheng, X.; Zhao, Q.-S.*, Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua. Chem. Commun. 2012, 48, 9038-9040.
**Paper highlighted by the “Hot off the Press” of Natural Product Reports (Hill, R. A.; Sutherland, A., Nat. Prod. Rep. 2012, 29, 1033-1037). link
5. Wu, X.-D.; He, J.; Shen, Y.; Dong, L.-B.; Pan, Z.-H.; Xu, G.; Gong, X.; Song, L.-D.; Leng, Y.; Li, Y.; Peng, L.-Y.; Zhao, Q.-S.*, Pseudoferic acids A–C, three novel triterpenoids from the root bark of Pseudolarix kaempferi. Tetrahedron Lett. 2012, 53, 800-803. link
4. Cheng, J.-T.; He, J.; Li, X.-Y.; Wu, X.-D.; Shao, L.-D.; Dong, L.-B.; Deng, X.; Gao, X.; Peng, L.-Y.; Cheng, X.; Li, Y.; Zhao, Q.-S.*, Three new sucrose fatty acid esters from Equisetum hiemale L. Helv. Chim. Acta 2012, 95, 1158-1163. link
3. Wu, X.-D.; Cheng, J.-T.; He, J.; Zhang, X.-J.; Dong, L.-B.; Gong, X.; Song, L.-D.; Zheng, Y.-T.; Peng, L.-Y.; Zhao, Q.-S.*, Benzophenone glycosides and epicatechin derivatives from Malania oleifera. Fitoterapia 2012, 83, 1068-1071. link
2011
2. Dong, L.-B.; He, J.; Wang, Y.-Y.; Wu, X.-D.; Deng, X.; Pan, Z.-H.; Xu, G.; Peng, L.-Y.; Zhao, Y.; Li, Y.; Gong, X.; Zhao, Q.-S.*, Terpenoids and norlignans from Metasequoia glyptostroboides. J. Nat. Prod. 2011, 74, 234-239. link
1. Dong, L.-B.; He, J.; Li, X.-Y.; Wu, X.-D.; Deng, X.; Xu, G.; Peng, L.-Y.; Zhao, Y.; Li, Y.; Gong, X.; Zhao, Q.-S.*, Chemical constituents from the aerial parts of Musella lasiocarpa. Nat. Prod. Bioprospect. 2011, 1, 41-47. link