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成果及论文

Journal Article (#equal contribution, *corresponding author):

Submitted:

43. Preparation of Electrospun Fucoidan-based Nanofibers and their Interaction with Endothelial Cells. (Submitted)

42. Metals and their Ions Promote Bone Repair and Regeneration by Mediating Osteolysis and Osteogenesis. (Under Review)

41. Nanomaterials for Sepsis Diagnosis and Therapy. (Submitted)

40. Role and possible mechanism of reactive oxygen species-mediated oxidative stress in the pathogenesis of oral lichen planus. (Under Review)

2020:

39. Yun He#, Wenwen Zhao#, Zuoxiang Dong, Yanjing Ji, Min Li, Yuanping Hao, Demeng Zhang, Changqing Yuan, Jing Deng, Peng Zhao *, Qihui Zhou *. A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing. International Journal of Biological Macromolecules 2020, 167: 182-192.

38. Qi Zhang, Yanjing Ji, Weiping Zheng, Mingzhe Yan, Danyang Wang, Min Li, Junbo Chen, Xiao Yan, Qiang Zhang, Xiao Yuan *, Qihui Zhou *. Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering. Journal of Nanomaterials. 2020. (Accepted)

37. Yaofang Fan, Yanming Liu, Qihui Zhou, Hao Du, Xueyang Zhao, Fei Ye, Huimin Zhao*. Catalytic hairpin assembly indirectly covalent on Fe3O4@C nanoparticles with high signal-to-background ratio for intracellular miRNAs visualization. Talanta. 2020. (Accepted)

36. Laís Ribovski, Qihui Zhou, Jiawen Chen, Ben L. Feringa, Patrick van Rijn*, Inge S. Zuhorn*. Light-induced molecular rotation triggers on-demand release from liposomesChemical Communications. 2020. (In Press)

35. Xiao-Fei Liu, Jun Zhang, Jiang-Jun Liu, Qihui Zhou, Zhongqiang Liu, Peng-Yue Hu, Zhe Yuan, Seeram Ramakrishna, Da-Peng Yang*, Yun-Ze Long*. Bifunctional CuS composite nanofibers via in situ electrospinning for outdoor rapid hemostasis and simultaneous ablating superbug. Chemical Engineering Journal 2020, 401: 126096.

34. Yuanping Hao #, Wenwen Zhao #, Liyu Zhang, Xi Zeng, Zhanyi Sun, Demeng Zhang, Peili Shen, Zhixin Li, Yantao Han, Peifeng Li*, Qihui Zhou*, Bio-multifunctional Alginate/Chitosan/Fucoidan Sponges with Enhanced Angiogenesis and Hair Follicle Regeneration for Promoting Full-Thickness Wound Healing. Materials & Design 2020, 193: 108863.

33. Baowei Li, Yuzhen Li, Longgang Hu, Ying Liu, Qihui Zhou, Man Wang, Yi An, Peifeng Li, Role of Circular RNAs in the Pathogenesis of Cardiovascular Disease. Journal of Cardiovascular Translational Research. https://doi.org/10.1007/s12265-019-09912-2.

32. Liangliang Yang, Lu Ge, Qihui Zhou, Taraneh Mokabber, Yutao Pei, Reinier Bron, Patrick van Rijn*, Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells. Advanced Materials Interfaces 2020: 2000385.

31. Zhongjie Yu, Qi Li, Jing Wang, Yali Yu, Yin Wang, Qihui Zhou*, Peifeng Li*, Reactive Oxygen Species Related Nanoparticle Toxicity in the Biomedical Field. Nanoscale Research Letters 2020, 15: 115.

30. Liangliang Yang, Lu Ge, Qihui Zhou, Klaudia Jurczak, Patrick van Rijn*, Decoupling amplitude and wavelength of anisotropic topography and the influence on osteogenic differentiation of stem cells using a high-throughput screening approach. ACS Applied Bio Materials. http://doi.org/10.1021/acsabm.0c00330

29. Wenwen Zhao, Chunxia Li, Hao Zhang, Qihui Zhou, Xuehong Chen, Yantao Han*, Xiuping Chen*, Dihydrotanshinone I attenuates plaque vulnerability in ApoE-/- mice: role of RIP3. Antioxidants and Redox Signaling. https://doi.org/10.1089/ars.2019.7796 

28. Yan Liu, Wenshuai Deng, Liangliang Yang, Xiuxiu Fu, Zhibin Wang, Patrick van Rijn *, Qihui Zhou *, Tao Yu*, Biointerface topography mediates the interplays between endothelial cells and monocytes. RSC Advances 2020, 10: 13848-13854.

27. Liangliang Yang, Qi Gao, Lu Ge, Qihui Zhou, Eliza M. Warszawik, Reinier Bron, King Wai Chiu Lai*, Patrick van Rijn*, Topography induced stiffness alteration of stem cells influences osteogenic differentiation. Biomaterials Science 2020,8: 2638-2652.

26. Lu Han, Liangliang Yang, Patrick van Rijn, Qingde Yin, Yanyan Yang, Yan Liu, Min Li, Mingzhe Yan, Qihui Zhou*, Tao Yu*  and Zhexun Lian*, Biointerface topography regulates phenotypic switching and cell apoptosis in vascular smooth muscle cells, Biochemical and Biophysical Research Communications 2020, 526: 841-847. 

25. Shuo Xu, Qihui Zhou, Zhongxin Jiang, Yanwen Wang, Kai Yang, Xiaohui Qiu, Qiuxia Ji*, The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease, Carbohydrate Polymers 2020: 116163.

24. Qihui Zhou, Jiawen Chen, Yafei Luan, Petteri A. Vainikka, Sebastian Thallmair,  Siewert J. Marrink, Ben L. Feringa*, Patrick van Rijn*. Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells, Science Advances 2020, 6: eaay2756.

媒体报道:

https://www.eurekalert.org

https://www.rug.nl/news

https://www.sciencedaily.com

https://www.regmednet.com

https://www.innovationtoronto.com

23. Xiaohui Qiu, Shuo Xu, Yuanping Hao, Brandon Peterson, Baowei Li, Kai Yang, Xiaofang Lv, Qihui Zhou*, Qiuxia Ji*. Biological effects on tooth root surface topographies induced by various mechanical treatments, Colloids and Surfaces B: Biointerfaces 2020, 188: 110748.

2019:

22. Torben AB van der Boon, Liangliang Yang, Linfeng Li, Daniel E Córdova Galván, Qihui Zhou, Jan de Boer, Patrick van Rijn*. Well Plate Integrated Topography Gradient Screening Technology for Studying Cell‐Surface Topography Interactions, Advanced Biosystems 2019, 4 (1): 1900218.

21. Ana Maria Almonacid Suarez, Qihui Zhou, Patrick van Rijn*, Martin C Harmsen*. Directional topography gradients drive optimum alignment and differentiation of human myoblasts, Journal of Tissue Engineering and Regenerative Medicine 2019, 13 (12): 2234-2245.

20. Shuo Xu, Qihui Zhou, Chun Fan, Hongmei Zhao, Yanwen Wang, Xiaohui Qiu, Kai Yang, Qiuxia Ji*. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts 2019, Archives of Oral Biology 2019, 107: 104514.

19. Taraneh Mokabber, Qihui Zhou, Antonis I. Vakis, Patrick van Rijn*, Yutao Pei. Mechanical and biological properties of electrodeposited calcium phosphate coatings, Materials Science and Engineering: C 2019, 100: 475-484.

18. Gabriel Romero Liguori, Qihui Zhou, Tácia Tavares Aquinas Liguori, Guilherme Garcia Barros, Philipp Till Kühn, Luiz Felipe Pinho Moreira, Patrick van Rijn*, Martin C Harmsen*. Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis, Stem cells international 2019, 5387850.

2018:

17. Guangyue Zu, Yi Cao, Jingjin Dong, Qihui Zhou, Patrick van Rijn, Min Liu*, and Renjun Pei*. Development of an AS1411-Conjugated α-Cyclodextrin-Based Polyrotaxane MRI Contrast Agent for Tumor Targeted Imaging, ACS Applied Bio Materials 2018, 2 (1): 406-416.

16. Qihui Zhou, Lu Ge, Carlos F. Guimarães, Philipp T. Kühn, Liangliang Yang, Patrick van Rijn*. Development of a Novel Orthogonal Double Gradient for High-Throughput Screening of Mesenchymal Stem Cells-Materials Interaction, Advanced Materials Interfaces 2018: 1800504.

15. Qihui Zhou, Zhiyuan Zhao, Gang Zhang, Ryan C. Chiechi*, Patrick van Rijn*. Directing stem cells with gold nanowire arrays, Advanced Materials Interfaces 2018: 1800334.

14. Gwenda F. Vasse, Philipp T. Kühn, Qihui Zhou, Shardul A. Bhusari, Catharina Reker-Smit, Barbro N. Melgert*, Patrick van Rijn*. Collagen morphology influences macrophage shape and marker expression in vitro, Journal of Immunology and Regenerative Medicine, 2018, 1: 13-20.

2017:

13. Qihui Zhou, Huilan Zhang, Ya Zhou, Zhepao Yu, Huihua Yuan, Bei Feng, Patrick van Rijn, Yanzhong Zhang*. Alkali-mediated miscibility of GT/PCL for electrospinning homogeneous composite nanofibers for tissue scaffolding. Macromolecular Bioscience, 2017, 17: 1700268.

12. Qihui Zhou, Olga Castañeda Ocampo, Carlos F Guimarães, Philipp T Kühn, Theo G van Kooten, Patrick van Rijn*. Screening platform for cell contact guidance based on inorganic biomaterial micro/nanotopographical gradients. ACS Appiled Materials & Interfaces, 2017, 9 (37): 31433-31445.

11. Giulio Abagnale, Antonio Sechi, Michael Steger, Qihui Zhou, Chao-Chung Kuo, Gülcan Aydin, Carmen Schalla, Gerhard Müller-Newen, Martin Zenke, Ivan G Costa, Patrick van Rijn, Arnold Gillner, Wolfgang Wagner*. Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies. Stem Cell Reports, 2017 9 (2): 654-666.

2016:

10. Qihui Zhou, Patrick Wünnemann, Philipp T. Kühn, Joop de Vries, Marta Helmin, Alexander Böker, Theo G van Kooten, Patrick van Rijn*. Mechanical properties of aligned nanotopologies for directing cellular behavior. Advanced Materials Interfaces 2016, 3, 18: 1600275.

9. Philipp T. Kühn, Qihui Zhou, Torben AB van der Boon, Aneta M Schaap-Oziemlak, Theo G van Kooten, Patrick van Rijn*. Double linear gradient biointerfaces for determining two-parameter dependent stem cell behavior. ChemNanoMat 2016, 2 (5): 407-413.

2015:

8. Huihua Yuan, Qihui Zhou, Biyun Li, Min Bao, Xiangxin Lou, Yanzhong Zhang*. Direct printing of patterned three-dimensional ultrafine fibrous scaffolds by stable jet electrospinning for cellular ingrowth, Biofabrication, 2015, 7(4): 045004.

7. Qihui Zhou, Philipp T Kühn, Thirsa Huisman, Elsje Nieboer, Charlotte Van Zwol, Theo G Van Kooten, Patrick Van Rijn*. Directional nanotopographic gradients: a high-throughput screening platform for cell contact guidance, Scientific Reports 2015, 5: 16240.

6. Qihui Zhou#, Jing Xie#, Min Bao, Huihua Yuan, Zhaoyang Ye, Xiangxin Lou, Yanzhong Zhang*. Engineering aligned electrospun PLLA microfibers with nano-porous surface nanotopography for modulating the responses of vascular smooth muscle cells, Journal of Materials Chemistry B 2015, 3 (21): 4439-4450.

2014:

5. Min Bao, Xiangxin Lou, Qihui Zhou, Wen Dong, Huihua Yuan, Yanzhong Zhang*. Electrospun biomimetic fibrous scaffold from shape memory polymer of PDLLA-co-TMC for bone tissue engineering, ACS Applied Materials & Interfaces 2014, 6 (4): 2611-2621.

2013:

4. Qihui Zhou, Min Bao, Huihua Yuan, Shifang Zhao, Wen Dong, Yanzhong Zhang*. Implication of stable jet length in electrospinning for collecting well-aligned ultrafine PLLA fibers, Polymer 2013, 54 (25): 6867-6876.

3. Shifang Zhao#, Qihui Zhou#, Yunze Long, Guanghui Sun, Yanzhong Zhang*. Nanofibrous patterns by direct electrospinning of nanofibers onto topographically structured non-conductive substrates, Nanoscale 2013, 5 (11): 4993-5000.

2. Min Bao, Qihui Zhou, Wen Dong, Xiangxin Lou, Yanzhong Zhang*. Ultrasound-modulated shape memory and payload release effects in a biodegradable cylindrical rod made of chitosan-functionalized PLGA microspheres, Biomacromolecules 2013, 14 (16): 1971-1979.

1. Min Bao, Yufeng Zhou, Qihui Zhou, Wen Dong, Yanzhong Zhang*. Recent Advances in the Ultrasound-Mediated Drug Delivery Systems, Chinese Journal of Biomedical Engineering 2013, 32 (6): 731-740.


Book Chapter (#equal contribution, *corresponding author):

2. “Electrospun Nanofibers. Chapter 6: Improving fiber alignment during electrospinning.” Editors: Mehdi Afshari; Authors: Huihua Yuan#, Qihui Zhou#, Yanzhong Zhang*. Elsevier. 2016; Reference: B978-0-08-100907-9.00006-4.

1. “Exploring Combined Influences of Material Topography, Stiffness and Chemistry on Cell Behavior at Biointerfaces”. Author: Qihui Zhou. ISBN (printed version): 978-94-034-0780-7.


专利(Patent):

4. “海洋生物多糖基复合海绵的制备方法、复合海绵及应用”,周祺惠,郝源萍,袁昌青,李培峰,申请公布号:CN110585474A2019

3. “一种岩藻多糖微纳米材料及其制备方法”,周祺惠,陈艺文,朱慧琳,郝源萍,王潆若,申请公布号:CN110184680A2019

2. Novel biomaterials substrates, cell culture systems comprising the same and uses thereof in cell screening applications” Patrick van Rijn, Martin C. Harmsen, Qihui ZhouPhilipp T. Kühn, Gabriel Liguori; Feb. 2017, P113777EP00 No. 17157897.4

1. “一种聚乳酸-三亚甲基碳酸酯纳米纤维薄膜的制备方法,张彦中,包敏,袁卉华,周祺惠,董文,娄向新,授权公布号:CN103397477B2015