Methods focuses on rapidly developing techniques in the experimental biologicaland medical sciences.
Each topical issue, organized by a guest editor who is an expert in the area covered, consists solely of invited quality articles by specialist authors, many of them reviews. Issues are devoted to specific technical approaches with emphasis on clear detailed descriptions of protocols that allow them to be reproduced easily. The background information provided enables researchers to understand the principles underlying the methods; other helpful sections include comparisons of alternative methods giving the advantages and disadvantages of particular methods, guidance on avoiding potential pitfalls, and suggestions for troubleshooting. 
Some recent thematic issues covered these hot topics: 

• Chromatin Structure 

• Editing and investigating genomes with TALE and CRISPR 

• Tools and Methods for Cellular Localization and Measurements 

• Recent development in bioinformatics for utilizing omics data 

• Nucleic Acids Nanotechnology 

• Systems Biology with Omics Data 

• Autophagy 

• Spatial mapping of multi-modal data in neuroscience 

• Advancing the boundaries of molecular cellular pathology 

• NGS applications to translational research 

• Detection and Quantification of Proteins in Clinical Samples Using Mass Spectrometry 

Full-length research articles or Reviews

Editor-in-Chief
Kenneth W. Adolph
University of Minnesota, Minneapolis, Minnesota, United States
Editor
Sun Kim
Seoul National University Department of Computer Science and Engineering, Seoul, Korea, Republic of
Brian McFarlin
University of North Texas, Denton, Texas, United States
Michelle Peckham
University of Leeds, Leeds, United Kingdom
Editorial Board
Jurg Bahler
University College London, London, United Kingdom
Vytas Bankaitis
University of North Carolina at Chapel Hill School of Medicine, Asheville, North Carolina, United States
Toni Cathomen
University of Freiburg, Freiburg im Breisgau, Germany
Jonathan Chaires
University of Louisville, Louisville, Kentucky, United States
David Corey
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States
Nancy Cox
University of Chicago, Chicago, Illinois, United States
Erica A. Golemis, PhD
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Allan Jacobson
University of Massachusetts Medical School, Worcester, Massachusetts, United States
Ulf Landegren
Uppsala University, Uppsala, Sweden
David M.J. Lilley
University of Dundee, Dundee, United Kingdom
James Manley
Columbia University, New York, New York, United States
Lynne Maquat
University of Rochester, Rochester, New York, United States
Tom Misteli, PhD
National Cancer Institute, Bethesda, Maryland, United States
Stephen Neidle
University College London, London, United Kingdom
Michael Pfaffl
Technical University of Munich Chair of Animal Physiology and Immunology, Freising-Weihenstephan, Germany
Cenk Sahinalp
Simon Fraser University, Burnaby, British Columbia, Canada
Thomas Schmittgen
University of Florida Health Science Center, Gainesville, Florida, United States
Marc H.V. Van Regenmortel
Higher School of Biotechnology Strasbourg, Illkirch, France
Johannes Walter
Harvard Medical School, Boston, Massachusetts, United States
Nils Walter
University of Michigan, Ann Arbor, Michigan, United States
Wei Wang
University of California San Diego Department of Chemistry and Biochemistry, La Jolla, California, United States
Limsoon Wong
National University of Singapore, Singapore, Singapore
Jerry Workman
Stowers Institute for Medical Research, Kansas City, Missouri, United States