Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs.
The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.
Coverage Includes

Studies on the interactions between cells and constructs are welcome, particularly where they advance our understanding of these processes or provide clear suggestions for improvements to existing systems. Surface modification technologies, their effects on protein adsorption and on cell seeding adhesion and proliferation are of major interest to the journal. Both in vitro and in vivo approaches will be considered, as the journal also aims to focus on in vivo responses to cell-material constructs. Typically, papers presenting the design, development or refinement of biomaterials or scaffolds will only be considered when these have been tested for their ability to support cellular attachment/interaction and/or growth, development and differentiation.
The journal also publishes manuscripts dealing with novel approaches to regenerative medicine that apply some type of controlled/sustained release strategy. Papers dealing with the development of carrier systems, cell encapsulation, release of drugs, growth factors, differentiation agents, and other types of bioactive agents, especially when they apply nanotechnology and/or non-invasive approaches, are particularly welcome. Works on the use of tissue engineering to develop novel drug discovery/testing methodologies and models are also of special interest. A particular emphasis is also to be placed on inductive scaffolds and matrices and on smart systems, including self-assembly materials, which will react to physiological stimuli and will elicit some exact and controllable response of specific cell types.
Research on the use of different cell types and methods for controlling their isolation, expansion and differentiation, and manuscripts describing the effects of manipulating cells, such as by gene therapy, or by supplying proteins, DNA or other biomolecules within the constructs used are also encouraged. Submissions of works on the derivation and maintenance of new stem cell lines and on the development of novel cocktails and serum free media for their culturing are also invited. Manuscripts addressing fundamental issues of stem cell biology, namely those related with stem cell plasticity, potency, clonality, etc., will be considered only if there is some discussion on potential strategies for their application in relevant clinical situations, in cell based therapies or regenerative medicine approaches. Papers on cell transplantation technologies, as well as on the use of stem cells in drug discovery are welcome. Works on relevant regulatory and ethical issues might also be considered.
The journal also focuses on the use of bioreactors for cell seeding, culturing and stimulation of cell differentiation. Papers on the effects of diffusion and mechanical stimulation of stem and progenitor cells are welcome. The design of novel bioreactors, the use of bioreactors for 2D and 3D tissue growth, as well as all production and scale-up aspects related to the use of bioreactors and its effect on the clinical introduction of new technologies will be welcomed. Papers on industrial and patent aspects of tissue engineering and regenerative medicine are also within the scope of the journal.

EDITOR-IN-CHIEF
Rui L. Reis
University of Minho, Taipas-Guimarães, Portugal
ASSOCIATE EDITORS
Anthony Atala
Wake Forest University, North Carolina, USA
Helena Azevedo
Queen Mary University London, UK
Alexandra Marques
University of Minho, Taipas-Guimarães, Portugal
Samuel I. Stupp
Northwestern University, Chicago, USA
EDITORIAL BOARD
C. Mauli Agrawal
University of Texas at San Antonio, San Antonio, USA
Joachim Aigner
Ludwig-Maximilians-University, Munich, Germany
Luigi Ambrosio
Institute of Composite and Biomedical Materials (IMCB-CNR), Naples, Italy
Augustinus Bader
University of Leipzig, Leipzig, Germany
Besim Ben-Nissan
University of Technology Sydney, Sydney, Australia
Aldo R. Boccaccini
University of Erlangen-Nurenberg, Germany
Barbara D. Boyan
Georgia Institute of Technology, Atlanta, USA
Karen J. Burg
Rhodes Research Center, Clemson, USA
Joaquim Sampaio Cabral
Instituto Superior Técnico, Lisbon, Portugal
Ranieri Cancedda
University of Genova, Genova, Italy
Yilin Cao
Shanghai Tissue Engineering Center, Shanghai, China
Arnold I. Caplan
Case Western Reserve University, Cleveland, USA
Guoping Chen
University of Tsukuba, Japan
Daniel Cohn
Hebrew University of Jerusalem, Jerusalem, Israel
Simon Cool
A*STAR's Institute of Medical Biology, Singapore
Fu Zhai Cui
Tsinghua University, Beijing, China
Jed Davies
University of Toronto, Toronto, Canada
Joost D. de Bruijn
Queen Mary University of London, London, UK
Utkan Demirci
Stanford University School of Medicine, USA
Paul Ducheyne
University of Pennsylvania, Philadelphia, USA
Gregory Dustin
University of Melbourne, Australia
Elazer R Edelman
Harvard University, Massachusetts, USA
Y. Murat Elcin
Ankara University, Ankara, Turkey
Changyou Gao
Zhejiang University, China
Andres J. Garcia
Georgia Institute of Technology, Atlanta, USA
Dan Gazit
Hebrew University of Jerusalem, Jerusalem, Israel
Jeffrey M. Gimble
Louisiana State University, Baton Rouge, USA
James Goh
National University of Singapore, Singapore
Alicia El Haj
Keele University, Keele, UK
Paul V. Hatton
University of Sheffield, Sheffield, UK
Jons Hilborn
Uppsala University, Uppsala, Sweden
Jeffrey Hubbell
École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Yu-Chen Hu
National Tsing Hua University, Hsinchu, Taiwan
John A Hunt
University of Liverpool, UK
Joseph Itskovitz-Eldor
Technion Israel Institute of Technology, Haifa, Israel
John A. Jansen
University of Nijmegen, Nijmegen, Netherlands
Yan Jin
Fourth Military Medical University, China
David L. Kaplan
Tufts University, Boston, USA
Ali Khademhosseini
Harvard University, Cambridge MA, USA
Gilson Khang
Chonbuk National University, Korea
Byung-Soo Kim
Hanyang University, Seoul, South Korea
Hae Won Kim
Dankook University, South Korea
Charles James Kirkpatrick
Johannes Gutenberg Universitt, Mainz, Germany
Jonathan Knowles
University College of London, London, UK
Deling Kong
Nankai University, China
Cato Laurencin
University of Connecticut, USA
Hai Bang Lee
Korea Research Institute of Chemical Technology, Daejeon, South Korea
Jin Ho Lee
Hannam University, South Korea
Kam W Leong
Columbia University, New York, USA
Jeong Ok Grace Lim
Kyungpook National University School of Medicine, Korea
Feng-Huei Lin
National Taiwan University,Taiwan
Wei Liu
Shanghai Tissue Engineering Center, Shanghai, China
Ivan Martin
University Hospital of Basel, Basel, Switzerland
Claudio Migliaresi
University of Trento, Trento, Italy
Antonios G. Mikos
Rice University, Houston, USA
Antonella Motta
University of Trento, Trento, Italy
Ralph Müller
Swiss Federal Institute of Technology, Zurich, Switzerland
Robert M. Nerem
Georgia Institute of Technology, Atlanta, USA
Kee Woei Ng
Nanyang Technological University, Singapore
Gordana V. Novakovic
Columbia University, New York, USA
Fergal O'Brien
Royal College of Surgeons Ireland, Ireland
Hajime Ohgushi
Research Institute for Cell Engineering (RICE), AIST, Osaka, Japan
Teruo Okano
Tokyo Women's Medical University, Tokyo, Japan
Richard OC. Oreffo
University of Southampton, Southampton, UK
Gerjo van Osch
Erasmus University, Rotterdam, The Netherlands
Abhay Pandit
National University of Ireland, Galway, Ireland
Erhan Piskin
Hacettepe University, Ankara, Turkey
Milica Radisic
University of Toronto, Canada
Michael Raghunath
National University of Singapore, Singapore
Seeram Ramakrishna
National University of Singapore
Buddy D. Ratner
University of Washington, Seattle, USA
A. Hari Reddi
University of California at Davis, Sacramento, USA
Heinz Redl
Ludwing Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
Julio San Roman
Instituto de Ciencia y Tecnologia de Polímeros, CSIC, Madrid, Spain
Michael V. Sefton
University of Toronto, Toronto, Canada
Dror Seliktar
Technion - Israel Institute of Technology, Israel
Michael Sittinger
Charité - University Medicine, Berlin, Germany
Molly Stevens
Imperial College, London, UK
Hsin-Wen Sung
National Tsing Hua University, Taiwan
Hwal Suh
Yonsei University, Yonsei, South Korea
Yasuhiko Tabata
Kyoto University, Kyoto, Japan
Tetsuya Tateishi
National Institute of Materials Science, Tsukuba, Japan
Swee Hin Teoh
Nanyang Technological University, Singapore
Rocky S Tuan
University of Pittsburgh School of Medicine, USA
Minoru Ueda
Nagoya University, Nagoya, Japan
Takashi Ushida
University of Tokyo, Tokyo, Japan
Clemens A. van Blitterswijk
University of Twente, Enschede, The Netherlands
Martijn van Griensven
Technical University Munich, Germany
William R. Wagner
University of Pittsburgh, Pittsburgh, USA
Anthony Weiss
University of Sydney, Australia
Masayuki Yamato
Tokyo Women's Medical University, Tokyo, Japan
James Yoo
Wake forest University, USA
Dimitrios Zeugolis
National University of Ireland, Galway, Ireland