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Editor-in-Chief  Chapel Hill, NCEditors Emeritus Annual Reviews Editor  University of Sussex,Genome Damage and Stability Centre,University of Sussex, Brighton, United Kingdom DNA damage response to DNA double strand breaksAssociate Editors  University of Sussex, United Kingdom Ageing, drug discovery, mitosis, neurodegeneration, proteomics The Institute of Cancer Research, United Kingdom Epigenetics and genome stability National Institutes of Health, United States V(D)J recombination, topoisomerase, non-homologous end joining, guanine quadruplex Duke University, United States Mechanisms of homologous recombination, transcription and genome stability University of Sussex, United Kingdom Xeroderma pigmentosum, Cockayne Syndrome, trichothiodystrophy University of Texas Southwestern Department of Radiation Oncology, United States DNA mismatch repair, genome instability, cancer, DNA Damage response, epigenetics, histone modifications and mutations, post-translational modifications University of California Los Angeles, California, United States Mutation, DNA repair University of Milan Department of Biomolecular Sciences at Biotechnology, Milan, ItalyGenome integrity, DNA damage checkpoints, initiation of DNA replication Columbia University Department of Genetics and Development, United States Email Rodney Rothstein Genome stability Massachusetts Institute of Technology Center for Environmental Health Sciences, United States Toxigenomics, animal models of DNA repair, DNA repair pathways, Genomic phenotyping, spontaneous mutagenesis, gene environment interactions, structure function relationship University of South Alabama, Mitchell Cancer Institute, Molecular and Metabolic Oncology Program, United States DNA Repair, base excision repair, DNA damage response, ADP-ribose, Poly-ADP-ribose polymerase, DNA polymerases, NAD+ metabolism Kyoto University Graduate School of Medicine Faculty of Medicine Department of Radiation Genetics, Japan Reverse genetics, radiation genetics UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER, United States DNA repair mechanisms UNIVERSITY OF PITTSBURGH CANCER INSTITUTE, University of Pittsburgh Cancer Institute, United States DNA Repair, drug discovery, redox pharmacology, pharmacology of cell and organ systems Leiden University Medical Centre Center for Human and Clinical Genetics, NetherlandsDNA damage responses, mutagenesis, DNA translesion synthesis, DNA mismatch repair National Institutes of Health, United States DNA replication, repair, and mutagenesis in eukaryotic and prokaryotic cellsEditorial Board Leiden University Medical Centre Center for Human and Clinical Genetics, Leiden, Netherlands Chromatin and DNA repair, systems biiology, ubiquitination, chromatin-modifying factors Hillman Cancer Center,Sch. of Medicine; Dept. of Radiation Oncology,University of Pittsburgh, Pittsburgh, Pennsylvania, United States Cancer pharmacology, DNA repair, radiation oncology, chemical biology University at Albany College of Nanoscale Science and Engineering, Albany, New York, United States DNA repair, genetic toxicology, environmental health, epitranscriptomics, tRNA modifications and translation University of Pittsburgh Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, United States double-strand break repair, homologous recombination, RAD51 regulation Wayne State University Department of Chemistry, Detroit, Michigan, United StatesFunctional genomics Southern Illinois University School of Medicine Department of Biochemistry and Molecular Biology, Carbondale, Illinois, United States Transcription, Chromatin Structure, DNA Repair, and Genomic Instability Margherita BignamiNational Institute of Health Department of Environment Health and Health, Roma, ItalyCampus Universidad Autónoma de Madrid,Spanish Research Council (CSIC) Genome Dynamics and Function,Centro de Biología Molecular Severo Ochoa, Madrid, SpainGenome maintenance and variability, enzymology of DNA replication and repair University of Florida Department of Biochemistry and Molecular Biology, Gainesville, Florida, United States DNA replication and repair Stony Brook University Department of Pharmacological Sciences, Stony Brook, New York, United States Mitochondrial DNA (mtDNA) replication, transcription and repair in animal cells Biomedical Research Center,Lab. of Molecular Gerontology,National Institute of Aging (NIA), Baltimore, Maryland, United States DNA repair, telomere maintenance, base excision DNA repair, helicase function, aging, neurodegeneration French Alternative Energies and Atomic Energy Commission Laboratory of Genetic and Molecular Radiobiology, Fontenay aux Roses, France Bethesda, MD, USA Chromosome biology Life Sciences Addition, room 1002,Dept. of Plant Biology,University of California, Davis, Davis, California, United States Cell and developmental biology, chromosome biology, environmental and Integrative biology, model plants, molecular biology, biochemistry and genomics Leiden Inst. of Chemistry (Scheikunde Universiteit Leiden),Molecular Genetics,Universiteit Leiden, Leiden, Netherlands Molecular genetics Div. of Molecular Radiation Biology,Dept. of Radiation Oncology,University of Texas Southwestern Medical Center, Dallas, Texas, United States DNA double-strand break repair, mechanisms of repair pathway choice, cell cycle checkpoint signaling, genomic instability and cancer development, targeting DNA repair pathways for cancer therapy University of Sussex,Genome Damage and Stability Centre,University of Sussex, Brighton, United Kingdom Genome stability Div. of Molecular Radiation Biology,Dept. of Radiation Oncology,University of Texas Southwestern Medical Center, Dallas, Texas, United States DNA repair and nuclear organization Harvard Medical School, Boston, MA, United States DNA double strand break repair, phosphatase, non-coding RNA Fac. of Medicine,Dept. of Nutrition,University of Oslo, Oslo, Norway Comet Assay, DNA damage and mutagenesis, nutrition and cancer, DNA repair in mammalian cells, human biomonitoring; molecular epidemiology E O Lawrence Berkeley National Laboratory, Berkeley, California, United States University at Albany Department of Biological Sciences, Albany, New York, United StatesBiochemistry of DNA repair enzymes, DNA repair in bacteria, structure and function of DNA nucleases, structure and function of DNA glycosylases, genetic and systems analysis of DNA repair pathways Dept. of Radiation Oncology,Dana-Farber Cancer Institute,Harvard Medical School, Boston, Massachusetts, United States Cancer susceptibility, Fanconi anemia, gene therapy, genetic risk University of California Davis Department of Chemistry, Davis, California, United StatesDNA repair enzymes Stony Brook University Department of Pharmacological Sciences, Stony Brook, New York, United States Biochemical and biological functions of repair pathways for oxidative DNA damage Gray Institute for Radiation Oncology and Biology, Oxford, United Kingdom DNA damage recognition, DNA damage signalling, DNA repair, G1 DNA damage checkpoint, DNA damage response regulation, cancer Atlanta, Georgia, USA DNA damage repair, radiation biology, genetic and genomic instability, mechanism of action of DNA targeting antitumor agents National Institute of Health Department of Environment Health and Health, Roma, ItalyGenome stability, DNA repair and replication, mutagenesis in cancer Massachusetts Institute of Technology Department of Biological Engineering, Cambridge, Massachusetts, United States Carcinogenesis, toxicology California State University Northridge Department of Chemistry and Biochemistry, Northridge, California, United States Protein biochemistry of DNA repair Molecular Virology, Immunology & Medical Genetics,Comprehensive Cancer Center,The Ohio State University, Columbus, Ohio, United States Biophysical mechanisms, genetics, regulation, and consequences of DNA repair and genome rearrangement in human cells Cancer Research Centre Marseille, Marseille, France Replication of damaged DNA, DNA polymerases, translesion synthesis, mutagenesis, DNA damage response Stanford University Department of Biology, Stanford, California, United States Genomic maintenance, transcription-coupled DNA repair in prokaryotes Columbia University Irving Medical Center, New York, New York, United StatesMaintenance of genome stability Erasmus Medisch Centrum,Dept. of Cell Biology & Genetics (Celbiologie & Genetica),Erasmus Universiteit, Rotterdam, Netherlands Non-homologous end-joining, BRCA1, BRCA2, PARP inhibitors, breast cancer, ovarian cancer Fac. of Medicine,Dept. of Cardiac Surgery,University of Calgary, Calgary, Alberta, CanadaIonizing Radiation, DNA repair, Chromatin Dynamics, DNA double strand break, Non-Homologous End-Joining, Alpha Particle, ATM, CHD3, CHD6 University of Southern California Section of Molecular and Computational Biology, Los Angeles, California, United States Molecular basis of mutagenesis, DNA replication fidelity, DNA repair, nucleotide metabolisms enzymes Leiden Inst. of Chemistry (Scheikunde Universiteit Leiden),Molecular Genetics,Universiteit Leiden, Leiden, Netherlands Mutagenesis, Bacterial genetics Stony Brook University Department of Pharmacological Sciences, Stony Brook, New York, United States Molecular carcinogenesis, mechanisms of DNA repair and mutagenesis in mammalian cells Rosenstiel Basic Medical Sciences Research Center, Waltham, Massachusetts, United States Homologous recombination, nonhomologous end-joining and repair, cell cycle regulation in response to DNA damage Sciences III,Dept. de Biologie Moléculaire (Dept. of Molecular Biology),Université de Genève, Geneve, Switzerland DNA replication stress in cancer National Institute of Genetics, Mishima, Japan Genome maintenance, translesion DNA synthesis, TLS polymerases, nucleotide excision repair, Xeroderma pigmentosum University of Copenhagen Department of Cellular and Molecular Medicine, København, Denmark DNA repair in eukaryotic cells, chromosome stability Erasmus Medisch Centrum,Dept. of Cell Biology & Genetics (Celbiologie & Genetica),Erasmus Universiteit, Rotterdam, Netherlands Mechanism of nucleotide excision repair Jun HuangZhejiang University, Hangzhou, ChinaUniversity of California San Diego, La Jolla, California, United States Systems biology, Gurdon Institute, Cambridge, United Kingdom DNA Repair, genomic DNA instability and cancer University of Mainz Institute of Toxicology, Mainz, Germany DNA repair, apoptosis Erasmus Medisch Centrum,Dept. of Cell Biology & Genetics (Celbiologie & Genetica),Erasmus Universiteit, Rotterdam, Netherlands DNA damage response CNRS Université Paris-XI,FRE 2939 Stabilité génétique et oncogenèse,Institut Gustave Roussy, Villejuif, France Translesion DNA synthesis Department of Microbiology and Molecular Genetics,McGovern Medical School,University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United StatesMechanisms of mutagenesis and chromosomes rearrangements in Saccharomyces cerevisiae. Inst. for Structural Biology,Rudolf-Virchow-Zentrum für Experimentelle Biomedizin,Julius-Maximilians-Universität Würzburg, Wurzburg, Germany Nucleotide excision repair, helicases, structure-based-drug design, structural biology New York University Department of Biochemistry and Molecular Pharmacology, New York, New York, United States Pathways of DNA damage avoidance, DNA repair and recombination, genomic instability, DNA damage checkpoints, cancer Oslo University Hospital, Oslo, Norway Modifications in DNA and RNA Howard Hughes Medical Institute - University of California San Diego School of Medicine, La Jolla, California, United States Genome instability in cancer Peking University School of Life Sciences, Beijing, China DNA replication, replication fork stability, repair of dsDNA breaks in eukaryotes University of California Davis Department of Microbiology and Molecular Genetics, Davis, California, United States Genetic recombination, DNA helicases, protein-nucleic acid interactions National Institute of Health (NIH),Lab. of Molecular Genetics,National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, United States Genome integrity, structural Biology, DNA replication fidelity Ctr. for Chromosome Biology,Sch. of Natural Sciences,National University of Ireland, Galway, Ireland Mismatch repair, mutagenesis, trinucleotide repeat expansion, MutS homologs, MutL homologs, neurological disease Susan LeDouxCollege of Medicine,Dept. of Cell Biology and Neuroscience,University of South Alabama, Mobile, Alabama, United StatesUniversity of Calgary Department of Biochemistry and Molecular Biology, Calgary, Alberta, Canada Molecular biology and disease, cell signalling and structure Wright State University Department of Biochemistry and Molecular Biology, Dayton, Ohio, United States Structural biology, DNA replication Randy LegerskiUNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, Texas, United StatesDept. of Neurology,Keck School of Medicine,University of Southern California, Los Angeles, California, United States DNA double-strand breaks roles in human cancer, aging, and the immune system University of California Berkeley Department of Molecular and Cell Biology, Berkeley, California, United States Enzymes and DNA binding proteins involved in DNA damage responses, DNA repair and replication in mammalian cells. Dosimetry and signaling for the DNA damage response. DNA polymerases. Generation of DNA damage by reactive oxygen species (ROS). University of Copenhagen Department of Biology, København, Denmark Homologous recombination, yeast Saccharomyces cerevisiae, protein quality control, DNA replication stress, telomere maintenance, nuclear organisation, DNA repair foci, DNA anaphase bridges Oregon Health & Science University, Portland, Oregon, United States DNA mismatch repair University of Michigan Department of Radiation Oncology, Ann Arbor, Michigan, United States Transcription, epigenetics, DNA damage responses, cancer biology, radiation biology Oregon Health & Science University Oregon Institute of Occupational Health Sciences, Portland, Oregon, United States Molecular mechanisms of DNA repair University of Washington Department of Pathology, Seattle, Washington, United StatesMutagenesis, cancer University of Bari Department of Bioscience Biotechnology and Biopharmaceutics, Bari, Italy University of Pittsburgh Department of Biomedical Informatics, Pittsburgh, Pennsylvania, United States Translational bioinformatics and systems/computational biology, natural language processing and text mining College of Veterinary Medicine, DCPAH,Dept. of Pathobiology and Diagnostic Investigation (PDI),Michigan State University, East Lansing, Michigan, United States DNA repair, serine/threonine protein kinases University of Kentucky Department of Toxicology and Cancer Biology, Lexington, Kentucky, United States DNA repair mechanisms University of São Paulo Department of Microbiology, São Paulo, Brazil DNA repair, Translesion synthesis, ultraviolet, mutagenesis, chemotherapy Duke University Nicholas School of the Environment, Durham, North Carolina, United States Environmental genotoxicants, mitochondrial DNA, mitophagy, Caenorhabditis elegans Houston Methodist Research Institute, Houston, Texas, United States Oxidative damage in mammalian genome and its linkage to transcription and involvement of non-canonical factors, microhomology-mediated end-joining of DNA double-strand breaks in tumor cells University of Zurich Institute of Pharmacology and Toxicology, Zurich, SwitzerlandNucleotide excision repair Kyushu University Medical Institute of Bioregulation, Fukuoka, Japan Reactive oxygen species Recombination and Genetic Instability, Paris, France Replication, DNA repair, genome instability, genomics and human genetics Icahn School of Medicine at Mount Sinai, New York, New York, United States Cell cycle regulation, genomic stability, chromosome dynamics UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States Cancer pharmacology, DNA repair Patricia OpreskoUniversity of Pittsburgh, Pittsburgh, Pennsylvania, United StatesUniversity of Texas at Austin Department of Molecular Biosciences, Austin, Texas, United States DNA damage response in eukaryotic cells Dept. of Internal Medicine,Sch. of Medicine,Wake Forest University, Winston-Salem, North Carolina, United States Biochemistry of DNA and RNA in human disease National Cancer Institute (NCI), Molecular Mechanisms Section, Bethesda, Maryland, United States DNA topoisomerase biology and biochemistry Div. of Genome Stability and DNA Repair,Dept. of Radiation Oncology,Dana-Farber Cancer Institute, Boston, Massachusetts, United States DNA double-strand breaks City of Hope National Medical Center Division of Head and Neck Surgery, Duarte, California, United States Radiation oncology, radiobiology Dept. of Microbiology and Molecular Genetics,Hillman Cancer Center,University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States Nucleotide excision repair Cardiff University Section of Pathology, Cardiff, United Kingdom Genome Instability National Institute of Health (NIH),Lab. of Molecular Genetics,National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, United States Genome stability, environmental factors, stress-signaling Baylor College of Medicine Department of Molecular and Human Genetics, Houston, Texas, United States Genome instability in evolution, antibiotic resistance, and cancer Georgetown University Medical Center Lombardi Comprehensive Cancer Center Dept. of Oncology, Washington, District of Columbia, United States DNA repair MRC Laboratory of Molecular Biology, Cambridge, United Kingdom DNA replication, DNA repair, translesion synthesis, DNA polymerases, DNA secondary structures, G quadruplexes, epigenetics University of Texas Southwestern Department of Neuroscience, Dallas, Texas, United States Cytogenetics, DNA repair, cancer, genome stability Fukuoka Dental College, Fukuoka, Japan Mutagenesis, carcinogenesis, fidelity of DNA replication Beckman Research Institute Department of Cancer Genetics and Epigenetics, Duarte, California, United States FEN1, DNA2, DNA Replication, DNA Repair, Cancer Biology DNA damage responses, genome integrity, protein posttranslational modifications, cancer genetics and epigenetics Dept. of Radiation Oncology,Rutgers Cancer Inst. of NJ,Rutgers University, New Brunswick, New Jersey, United States Mechanisms of genomic instability, replication stress, tumorigenesis, mitosis Sackler School of Medicine,Dept. of Human Molecular Genetics and Biochemistry,Tel Aviv University, Tel Aviv, Israel Genome instability in human morbidity and aging Osaka University Research Institute for Microbial Diseases, Osaka, Japan Cancer Research UK Inst. for Cancer Studies,Sch. of Cancer Sciences,University of Birmingham, Birmingham, United Kingdom DNA repair Northeastern University Department of Biology, Boston, Massachusetts, United StatesDNA repair, AP endonuclease Kobe University Biosignal Research Center, Kobe, Japan Signal transduction, DNA repair Patrick SungYale University Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut, United StatesClare Hall Lab.,London Research Inst.,Cancer Research UK, Herts, United KingdomTranscription, DNA replication and repair Yale University Department of Therapeutic Radiology, New Haven, Connecticut, United States Mutagenesis, autoimmunity, genomic instability, DNA damage, DNA repair Kiyoji TanakaDept. of Cardiology,Graduate School of Comprehensive Human Sciences,University of Tsukuba, Tsukuba, JapanDept. of Biochemistry & Molecular Biology,Dept. of Medicine,Indiana University School of Medicine, Indianapolis, Indiana, United States DNA repair pathways, proteomics, markers of chemotherapeutic responsiveness Institute of Molecular Biology, Mainz, Germany Ubiquitin, SUMO, polyubiquitin chains, ubiquitin protein ligases (E3), ubiquitin-conjugating enzymes (E2), DNA repair, DNA replication, DNA replication stress, DNA damage response, mutagenesis, genome stability, yeast genetics,biochemistry National Institute of Public Health and the Environment, Bilthoven, Netherlands DNA repair, aging, biological clock Division of Pharmacology and Toxicology,Dell Pediatric Research Institute,University of Texas at Austin, Austin, Texas, United States DNA damage and repair, genomic instability, gene targeting, DNA structure, cancer therapeutics University of Cambridge Department of Oncology, Cambridge, United KingdomChomosomal instability in cancer pathogenesis and treatment Erasmus Medisch Centrum,Dept. of Cell Biology & Genetics (Celbiologie & Genetica),Erasmus Universiteit, Rotterdam, Netherlands Molecular mechanisms of DNA repair, genome stability in cancer Fac. der Geneeskunde, Divisie 5,Toxicogenetica,Universiteit Leiden, Leiden, NetherlandsToxicogenomics Salk Institute for Biological Studies, La Jolla, California, United States Gene expression, cancer Massachusetts Institute of Technology Department of Biology, Cambridge, Massachusetts, United States Mutagenesis, translesion synthesis, TLS DNA polymerases, cellular responses to DNA damage, oxidative stress Research Center for Eco-Environmental Sciences,State Key Laboratory of Environmental Chemistry and Ecotoxicology,Chinese Academy of Sciences (CAS), Beijing, ChinaHomologous recombination, RecA, Rad51, single stranded binding protein, DNA damage detection, ultrasensitive assay, single molecule fluorescence study, protein-DNA interaction, protein assembly and disassembly University of Kentucky Department of Toxicology and Cancer Biology, Lexington, Kentucky, United States DNA damage-induced mutagenesis, DNA excision repair Francis Crick Institute, London, United Kingdom Mechanisms of genetic recombination, DNA strand break repair Shanghai Institute of Biochemistry and Cell Biology, Shanghai, China Base excision repair, deamination, DNA demethylation, epigenetics Shenzhen University College of Medicine, Shenzhen, China DNA damage response, DNA double strand break, DNA replication, replication stress, post-translational modifications, ubiquitination, UFMylation. Beijing Institute of Genomics Chinese Academy of Sciences, Beijing, ChinaEpitranscriptomic regulations, mechanisms of RNA methylation Hongfeng YuanBeckman Research Institute of the City of Hope Department of Cancer Biology, Duarte, California, United StatesPrinceton University Department of Molecular Biology, Princeton, New Jersey, United States DNA replication and chromosome structure in yeast; telomeres; replication fork progression University of Miami Department of Biochemistry and Molecular Biology, Miami, Florida, United States DNA interstrand crosslink repair, double strand break repair, mismatch repair, translesion synthesis, genome instability, Fanconi anemia, cancer, biochemistry, genetics Department of Biochemistry and Molecular Biology Shenzhen University School of Medicine, Shenzhen, China Histone modifications, DNA damage responses, Epigenetics, p53, Autophagy
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