Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms. The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments.

Each issue of Cancer and Metastasis Reviews is devoted to a particular theme or topic and will contain from five to seven different contributions. In addition, an introductory preface is included from an individual who is distinguished in the field to be covered. The topics and contributors are chosen by the Editor-in-Chief after consultation with various members of the Editorial Advisory Board. Special emphasis is placed on subjects which are of relevance to the molecular and cellular biology of cancer metastasis and tumor progression, as well as to the treatment of metastatic disease. Occasional issues will be devoted to an in-depth clinical and biological analysis of a particular type of cancer.

A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.

Editors-in-Chief:
Kenneth V. Honn
Distinguished Professor of Pathology, Oncology and Chemistry
Wayne State University School of Medicine, Detroit, MI, USA
Avraham Raz
Paul Zuckerman Professor of Oncology and Pathology,
Barbara Ann Karmanos Cancer Institute
Wayne State University, School of Medicine, Detroit, MI, USA
Editorial Advisory Board:
Robin Anderson, Peter MacCallum Cancer Center, Australia 
Menashe Bar-Eli, UTMD Anderson Cancer Center, USA 
Ann F. Chambers, London Health Sciences Center, Canada; 
Michael Cher, Wayne State University School of Medicine, USA
David Cheresh, University of California, San Diego, USA 
Isaiah J. Fidler, UTMD Anderson Cancer Center, USA
Paul Fisher, Virginia Commonwealth, USA
Mary J.C. Hendrix, Children's Hospital of Chicago Research Center, USA 
Meenhard Herlyn, The Wistar Institute, USA 
Yusuf Hannun, Stony Brook University, USA
Mien-Chie Hung, University of Texas MD Anderson Cancer Center, USA
John T. Isaacs, The Johns Hopkins Oncology Center, USA 
Rakesh Kumar, Rajiv Gandhi Centre for Biotechnology, India
Lawrence J. Marnett, Vanderbilt University School of Medicine, USA 
Dipak Panigrahy, Harvard Medical School, USA
Richard Phipps, University of Rochester Medical Center, USA
Kenneth J. Pienta, Johns Hopkins University, USA 
Charles Serhan, Harvard Medical School, USA
Bonnie Sloane, Wayne State University School of Medicine, USA 
Saburo Sone, Tokushima University School of Medicine, Japan 
Joszef Timar, Semmelweis University, Hungary 
Danny Welch, Kansas University Cancer Center, USA


Founding Editors: 
Isaiah J. Fidler
Garth L. Nicolson
George Poste