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研究领域

天然抗癌药物结构修饰、构效关系、分子生物学作用机理研究,中药现代复方制剂与评价,新型生物医学功能材料的研究等。 1.天然抗癌新药 2.药物新剂型 3.药代动力学 4.分子生物学机理 5.新型生物医学材料

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Shixuan Zhang et.al, Nitrogen-containing Flavonoid Analogues as CDK1/Cyclin B Inhibitors: Synthesis, SAR Analysis, and Biological Activity,Bioorganic & Medicinal Chemistry,Online publication complete: 16:7127-7132,2008 (SCI IF2.687) Shixuan Zhang*, Xiaona Li, Fenghong Zhang, Puwen Yang, Xiujuan Gao, Qiling Song, Preparation of Yuanhuacine and relative daphne diterpene estersfrom Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I, Bioorganic & Medicinal Chemistry 14:3888-3895,2006(SCI IF2.687) Shixuan Zhang*, Fenghong Zhang, Xiaona Li, Luohan Wen, Shisheng Wang, Fingerprint of daphne diterpene esters from Daphne genkwa by high-performance liquid chromatography and quantitative analysis and anticancer activity of yuanhuacine,Phytochemical Analysis,18:91-97, 2007 (SCI IF 1.228)

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