个人简介
李韶，女，博士学位，博士后经历，教授，博士及硕士研究生导师。
辽宁省脑疾病神经保护与损伤修复重点实验室主任、辽宁省省级高校脑疾病研究重点实验室主任、大连医科大学生理学教研室主任。长期从事神经生理学研究，主持完成国家级课题5项，省部级课题7项，近5年通讯作者发表SCI论文21篇，第一完成和合作完成人身份获国际专利1项、国内专利1项，教育部科技进步二等奖1项，省科技进步二等奖2项、三等奖2项。
学习经历：
2004/09 - 2007/07，生理学博士，大连医科大学与新加坡国立大学联合培养
1989/09 - 1992/07，生理学系硕士，华中科技大学同济医学院
1982/09 - 1987/07，医疗系学士，滨州医学院
工作经历：
2000/09 -至今，教授、博士研究生导师，大连医科大学
2009/01 - 2009/05，Research Fellow，Department of Pharmacology, Yong Loo Lin School of Medicine, Centre for Life Sciences, National University of Singapore, Singapore，PI: Dr. Gavin S Dawe
2005/09 - 2008/07，Research Scientist，Institute of Molecular and Cellbiology, Department of Clinical Research, Singapore General Hospital, Singapore，PI: Zhicheng Xiao
1999/12 - 2000/08，高级访问学者，中国科学院上海生理所赵志奇教授研究组
1996/01 - 1996/12，高级访问学者，华中科技大学同济医学院实验医学中心李之望教授膜片钳实验室
1987/07 - 2000/07，助教、讲师、副教授，滨州医学院
研究方向：
神经退行性疾病发病机制及防治策略的研究
主要学术任职：
中国神经科学会神经内稳态与内分泌分会副主任委员；
中国老年学和老年医学学会抗衰老分会理事
辽宁省神经科学会副理事长；
大连市医学会第十届理事会常务理事；
中国生理学会大连市分委会候任主任委员；
承担的国家级项目（近5年）：
1.国家科技部新药创制重大专项（2018ZX09301028-001），抗难治性癫痫I类新药蝎毒耐热肽的研发，400万，2018.01-220.12，第2位
2.辽宁省教育厅高等学校自然科学重点类项目（LZ2017001），抗难治性癫痫药蝎毒耐热肽临床前药代动力学研究 10万，2017.09-2020.08，主持人
3.国家自然基金面上项目（81571061），Nav1.6在阿尔茨海默病神经网络异常中的作用及机制，2016.01-2019.12，57万，主持人。
4.国家自然基金面上项目（81371223），阿尔茨海默病郎飞结区Aβ生成及调控的分子机制研究，2014/01-2017/12，65万元，主持人。
5.国家自然基金重点项目（81230084/H27），情之所致糖尿病认知功能障碍的机理及滋补脾阴法防治的基础研究，2013/01-2017/12，180万，第3位。
6.高等学校博士点基金博导类课题（20122105110010），郎飞氏结处淀粉样前体蛋白代谢异常及其调控靶点的研究，2013/01-2015/12，12万，主持人。
7.癫痫药物的行为学及电生理学筛选，横向合作课题，15万，2015.07-2015.11，主持人
8.癫痫药物的筛选，横向合作课题，10万元，2014.01-2014.12，主持人
代表性论文（近5年）：（* 通讯作者）
1. Chen JJ, Zhao B, Zhao J*, Li S*. Potential roles of exosomal microRNAs as diagnostic biomarkers and therapeutic application in Alzheimer’s disease. Neural Plasticity. 2017; 2017:7027380. doi: 10.1155/2017/7027380. Epub 2017 Jul 9.
2. Lan YL, Chen JJ, Hu G, Xu J, Xiao M*, Li S*. Aquaporin 4 in astrocytes is a target for therapy in Alzheimer's disease. Current Pharmaceutical Design. Current Pharmaceutical Design. 2017;23(33):4948-4957. doi: 10.2174/ 1381612823666170714144844.
3. Wang B, Wang Y, Wu Q, Huang HP*, Li S*. Effects ofα2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression. Frontiers in Neuroscience.2017 May 1; 11: 243. doi: 10.3389/fnins.2017.00243. eCollection 2017
4. Li S*，Wang X, Ma QH, Yang WL, Zhang, XG, Dawe GS* and Xiao ZC*. Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway. Scientific Reports ,2016 Dec 23; 6:39320, DOI: 10.1038/srep39320
5. Lan YL#, Zhao J#, Ma TH*, Li S*. The potential roles of aquaporin 4 in Alzheimer's disease. MOLECULAR NEUROBIOLOGY. 2016 Oct; 53(8):5300-9. doi: 10.1007/ s12035-015-9446-1. 2016 Oct 53(8)：5300-9
6. Zhang XG#, Wang #, Zhou TT, Wu XF, PengY, Zhang WQ, Zhao J*, Li S*, Title: Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans fromβ-Amyloid Toxicity. Front Pharmacol. 2016 Jul 26; 7: 227. doi: 10.3389/fphar.2016.00227. eCollection 2016.
7. Chen JJ, Wang T, An CD, Jiang CY, Zhao J, Li S*. Brain-derived neurotrophic factor: a mediator of inflammation-associated. Rev Neurosci. 2016 Dec 1;27(8):793-811. doi: 10.1515/revneuro-2016-0017.
8. Wang X#, Zhang XG#, Zhou TT, Li, Jang CL, Xiao ZC, Ma QH, Li S*. Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1-42. Frontiers in Neuroscience, 2016, published: 09 March 2016 doi: 10.3389/fnins.2016.00094
9. Lan YL, Zou S, Zhang C, Li J, Xu Y, Li S* Update on the effect of estradiol in postmenopause women with Alzheimer's disease: A systematic review. Acta Neurol Belg, 2016 Sep; 116(3): 249-57.
10. Lan YL#, Zou S#, Chen JJ, Zhao J*, Li S*. The neuroprotective effect of the association of aquaporin-4/glutamate transporter 1 (AQP4/GLT-1) against Alzheimer’s disease. Neural Plasticity. 2016 (2016), Article ID 4626593, 8 pageshttp://dx.doi.org/10.1155 /2016/ 4626593.
11. Lan YL, Zhao J, Ma TH*, Li S*. The research update on the potential roles of aquaporin 4 in neuroinflammation. Acta Neurol Belg, 2016 Jun;116(2):127-34
12. Yang JY*, Wei W, Liu JQ, Lan YL, Wang HB, Li S*. Role of bladder hydrodistention and intravesical sodium hyaluronate in the treatment of interstitial cystitis. Urology Journal.2015,12(06): 2417-2421.
13. Zhou TT#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease. Int Immunopharmacol. 2015 Nov 5. pii: S1567-5769(15) 30165 -X. doi: 10.1016/j.intimp.2015.10.032.
14. Zhou T#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease. Neuropharmacology. 2015 Oct 23; 101: 480-489. doi: 10.1016/j.neuropharm. 2015.10.024.
15. Lan YL#, Zhao J#, Ma TH*, Li S*. The great significance of research into the physiological relevance between AQP4 and vasopressin for studying Alzheimer's disease. J Alzheimers Dis Parkinsonism. 5: 192. doi:10.4172/2161- 0460.1000192
16. Cao Z, Wu XF, Peng Y, Zhang R, Li N, Yang JY, Zhang SQ, Zhang WQ, Zhao J*,Li S*. Scorpion Venom Heat-Resistant Peptide Attenuates Glial Fibrillary Acidic Protein Expression via c-Jun/AP-1. Cell Mol Neurobiol. 2015 Nov;35(8):1073-9. doi: 10.1007/s10571-015-0215-5. Epub 2015 Jul 2.
17. Yang JY*, Yang G, Ren J, Zhao J*, Li S*. Caffeine suppresses GABA receptor-mediated current of rat primary sensory neurons via inhibiting intracellular phosphodiesterase. Neurophysiology. April 2015, Volume 47, Issue 2, pp 108-114
18. Lan YL, Zhao J, Li S*. Update on the Neuroprotective Effect of Estrogen Receptor Alpha against Alzheimer’s disease. J Alzheimer’s Dis.2015; 43(4):1137-48.
19. Zhang MY, Zheng CY, Zou MM, Zhu JW, Zhang Yan, Sun M, Wang J, Liu CF, Xiao ZC, Li S *, Ma QH and Xu RX. Lamotrigine Attenuates Deficits in Synaptic Plasticity and Accumulation of Amyloid Plaques in APP/PS1 Transgenic Mice. Neurobiol Aging. 2014 Dec; 35(12):2713-25.
20. Wang T, Wang SW, Zhang Y, Wu XF, Peng Y, Cao Z, Ge BY, Wang X, Wu Q, Lin JT, Zhang WQ, Li S*, Zhao J. Scorpion Venom Heat-Resistant Peptide (SVHRP) Enhances Neurogenesis and Neurite Outgrowth of Immature Neurons in Adult Mice by Up-Regulating Brain-Derived Neurotrophic Factor (BDNF). PLoS One.2014 Oct 9; 9(10): e109977.
21. Jintao Lin, Shuangyue Li, Mingzhong Sun, Cuili Zhang, Wenbo Yang, Zehui Zhang, Xiaojie Li and Shao Li*，Microbial lipid production by oleaginous yeast in D-xylose solution using a two-stage culture mode. RSC Advance 2014 (4): 34944-34949.
22. Lan YL, Zhao J, Li S*. Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity. Neurol Sci. 2014 Nov; 35(11):1657-62.
23. Song Y, Li S, Song B, Zhang Y, Gao W, Li N, Fan K, Ma J*. The pathological changes in the spinal cord after dural tear with and without autologous fascia repair. Eur Spine J 2014 (23):1531-1540.
24. Xu DE, Zhang WM, Yang ZZ, Zhu HM, Yan K, Li S, Bagnard D, Dawe GS, Ma QH, Xiao ZC*. Amyloid precursor protein at node of Ranvier modulates nodal formation.Cell Adh Migr. 2013 Dec; 29(6): 752-60.
25. Wang ZC, Zhao J, Li S*，Dysregulation of Synaptic and ExtrasynapticN-methyl-D-aspartate receptors induced by amyloid-β. Neurosci Bull.2013 Dec; 29(6): 752-60. doi: 10.1007/s12264-013-1383-2.
26. Li X, Liu J, Liang S, Guan K, An L, Wu X, Li S, Sun C*. Temporal Modulation of Sodium Current Kinetics in Neuron Cells by Near-Infrared Laser. Cell Biochem Biophys. 2013 Dec; 67(3): 1409-19.
学术专著（近5年）：
1.主编: 关兵才, 张海林, 李之望。李韶参编, 细胞电生理学基本原理与膜片钳技术, 科学出版社, 55.5万字, 2013，ISBN 978-7-03-035845-5
2.主编: 刘佳, 隋鸿锦。李韶参编, 神经科学-基础与临床, 人民卫生出版社, 52.7万, 2014
3.主编：杨宝学。李韶参编，《Aquaporins》，Springer出版社，2017ISBN 978-94-024-1055-6. 2017
科研获奖（近5年）：
1.李韶（3/15）, 基于纳米复合材料的干细胞神经损伤修复关键技术体系的创建和应用, 教育部，高等学校科学研究优秀成果奖（科学技术）科技进步，二等奖，2016,
2.李韶（1/7），钠通道亚型Nav1.6与阿尔茨海默病发病机制相关性的基础与临床研究，辽宁省科技进步，三等奖，2015，证书编号2015J-3-095-1
3.李韶（1/5），Nav1.6与阿尔茨海默病发病机制相关性及其干预靶点的研究，,辽宁省医学会，辽宁省医学会科技进步，三等奖，2015，证书编号2015-3-09-01
4.李韶(2/9)，中药蝎毒治疗难治性癫痫的基础与临床研究，辽宁省政府，辽宁省科学技术奖，二等奖，2013，证书编号：2013J-2-58-02。
专利申请：
1. Modulation of Neural Activity and/or Condition. US Patent No. 60/841,6302008.03.06（Zhicheng Xiao, Quanhong Ma, Shao Li，Gavin S Davin）
2.一种耐热合成肽及其用途，专利号：ZL2016 10645111.7（赵杰李韶张万琴）
联系方式：
Email:lishao89@hotmail.com,lishao89@dlmedu.edu.cn
办公电话：0411-86110352
近期论文
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（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1. Chen JJ, Zhao B, Zhao J*, Li S*. Potential roles of exosomal microRNAs as diagnostic biomarkers and therapeutic application in Alzheimer’s disease. Neural Plasticity. 2017; 2017:7027380. doi: 10.1155/2017/7027380. Epub 2017 Jul 9.
2. Lan YL, Chen JJ, Hu G, Xu J, Xiao M*, Li S*. Aquaporin 4 in astrocytes is a target for therapy in Alzheimer's disease. Current Pharmaceutical Design. Current Pharmaceutical Design. 2017;23(33):4948-4957. doi: 10.2174/ 1381612823666170714144844.
3. Wang B, Wang Y, Wu Q, Huang HP*, Li S*. Effects ofα2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression. Frontiers in Neuroscience.2017 May 1; 11: 243. doi: 10.3389/fnins.2017.00243. eCollection 2017
4. Li S*，Wang X, Ma QH, Yang WL, Zhang, XG, Dawe GS* and Xiao ZC*. Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway. Scientific Reports ,2016 Dec 23; 6:39320, DOI: 10.1038/srep39320
5. Lan YL#, Zhao J#, Ma TH*, Li S*. The potential roles of aquaporin 4 in Alzheimer's disease. MOLECULAR NEUROBIOLOGY. 2016 Oct; 53(8):5300-9. doi: 10.1007/ s12035-015-9446-1. 2016 Oct 53(8)：5300-9
6. Zhang XG#, Wang #, Zhou TT, Wu XF, PengY, Zhang WQ, Zhao J*, Li S*, Title: Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans fromβ-Amyloid Toxicity. Front Pharmacol. 2016 Jul 26; 7: 227. doi: 10.3389/fphar.2016.00227. eCollection 2016.
7. Chen JJ, Wang T, An CD, Jiang CY, Zhao J, Li S*. Brain-derived neurotrophic factor: a mediator of inflammation-associated. Rev Neurosci. 2016 Dec 1;27(8):793-811. doi: 10.1515/revneuro-2016-0017.
8. Wang X#, Zhang XG#, Zhou TT, Li, Jang CL, Xiao ZC, Ma QH, Li S*. Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1-42. Frontiers in Neuroscience, 2016, published: 09 March 2016 doi: 10.3389/fnins.2016.00094
9. Lan YL, Zou S, Zhang C, Li J, Xu Y, Li S* Update on the effect of estradiol in postmenopause women with Alzheimer's disease: A systematic review. Acta Neurol Belg, 2016 Sep; 116(3): 249-57.
10. Lan YL#, Zou S#, Chen JJ, Zhao J*, Li S*. The neuroprotective effect of the association of aquaporin-4/glutamate transporter 1 (AQP4/GLT-1) against Alzheimer’s disease. Neural Plasticity. 2016 (2016), Article ID 4626593, 8 pageshttp://dx.doi.org/10.1155 /2016/ 4626593.
11. Lan YL, Zhao J, Ma TH*, Li S*. The research update on the potential roles of aquaporin 4 in neuroinflammation. Acta Neurol Belg, 2016 Jun;116(2):127-34
12. Yang JY*, Wei W, Liu JQ, Lan YL, Wang HB, Li S*. Role of bladder hydrodistention and intravesical sodium hyaluronate in the treatment of interstitial cystitis. Urology Journal.2015,12(06): 2417-2421.
13. Zhou TT#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease. Int Immunopharmacol. 2015 Nov 5. pii: S1567-5769(15) 30165 -X. doi: 10.1016/j.intimp.2015.10.032.
14. Zhou T#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease. Neuropharmacology. 2015 Oct 23; 101: 480-489. doi: 10.1016/j.neuropharm. 2015.10.024.
15. Lan YL#, Zhao J#, Ma TH*, Li S*. The great significance of research into the physiological relevance between AQP4 and vasopressin for studying Alzheimer's disease. J Alzheimers Dis Parkinsonism. 5: 192. doi:10.4172/2161- 0460.1000192
16. Cao Z, Wu XF, Peng Y, Zhang R, Li N, Yang JY, Zhang SQ, Zhang WQ, Zhao J*,Li S*. Scorpion Venom Heat-Resistant Peptide Attenuates Glial Fibrillary Acidic Protein Expression via c-Jun/AP-1. Cell Mol Neurobiol. 2015 Nov;35(8):1073-9. doi: 10.1007/s10571-015-0215-5. Epub 2015 Jul 2.
17. Yang JY*, Yang G, Ren J, Zhao J*, Li S*. Caffeine suppresses GABA receptor-mediated current of rat primary sensory neurons via inhibiting intracellular phosphodiesterase. Neurophysiology. April 2015, Volume 47, Issue 2, pp 108-114
18. Lan YL, Zhao J, Li S*. Update on the Neuroprotective Effect of Estrogen Receptor Alpha against Alzheimer’s disease. J Alzheimer’s Dis.2015; 43(4):1137-48.
19. Zhang MY, Zheng CY, Zou MM, Zhu JW, Zhang Yan, Sun M, Wang J, Liu CF, Xiao ZC, Li S *, Ma QH and Xu RX. Lamotrigine Attenuates Deficits in Synaptic Plasticity and Accumulation of Amyloid Plaques in APP/PS1 Transgenic Mice. Neurobiol Aging. 2014 Dec; 35(12):2713-25.
20. Wang T, Wang SW, Zhang Y, Wu XF, Peng Y, Cao Z, Ge BY, Wang X, Wu Q, Lin JT, Zhang WQ, Li S*, Zhao J. Scorpion Venom Heat-Resistant Peptide (SVHRP) Enhances Neurogenesis and Neurite Outgrowth of Immature Neurons in Adult Mice by Up-Regulating Brain-Derived Neurotrophic Factor (BDNF). PLoS One.2014 Oct 9; 9(10): e109977.
21. Jintao Lin, Shuangyue Li, Mingzhong Sun, Cuili Zhang, Wenbo Yang, Zehui Zhang, Xiaojie Li and Shao Li*，Microbial lipid production by oleaginous yeast in D-xylose solution using a two-stage culture mode. RSC Advance 2014 (4): 34944-34949.
22. Lan YL, Zhao J, Li S*. Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity. Neurol Sci. 2014 Nov; 35(11):1657-62.
23. Song Y, Li S, Song B, Zhang Y, Gao W, Li N, Fan K, Ma J*. The pathological changes in the spinal cord after dural tear with and without autologous fascia repair. Eur Spine J 2014 (23):1531-1540.
24. Xu DE, Zhang WM, Yang ZZ, Zhu HM, Yan K, Li S, Bagnard D, Dawe GS, Ma QH, Xiao ZC*. Amyloid precursor protein at node of Ranvier modulates nodal formation.Cell Adh Migr. 2013 Dec; 29(6): 752-60.
25. Wang ZC, Zhao J, Li S*，Dysregulation of Synaptic and ExtrasynapticN-methyl-D-aspartate receptors induced by amyloid-β. Neurosci Bull.2013 Dec; 29(6): 752-60. doi: 10.1007/s12264-013-1383-2.
26. Li X, Liu J, Liang S, Guan K, An L, Wu X, Li S, Sun C*. Temporal Modulation of Sodium Current Kinetics in Neuron Cells by Near-Infrared Laser. Cell Biochem Biophys. 2013 Dec; 67(3): 1409-19.
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