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个人简介

教育经历 1991.91994.7 大连市金州高中无 2001.42006.6 大连理工大学生物化工博士 1994.91998.7 辽宁大学微生物学士 工作经历 2006.6至今 大连理工大学化工学院高校教师

研究领域

干细胞与组织工程 精准转化医学智能材料 神经系统疾病药物筛选及毒性评价 微生态大脑保护

近期论文

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Shuping Wang, Shui Guan*, Changkai Sun, Hailong Liu, Tianqing Liu, Xuehu Ma. Electrical stimulation enhances the neuronal differentiation of neural stem cells in three-dimensional conductive scaffolds through the voltage-gated calcium ion channel. Brain Res. 2023 Jan 1;1798: 148163. (SCI, IF=3.61, JCR Q3) Yujiao Yan#, Shui Guan#*, Shuping Wang, Jianqiang Xu, Changkai Sun*. Synthesis and characterization of protocatechuic acid grafted carboxymethyl chitosan with oxidized sodium alginate hydrogel through the Schiff's base reaction. Int J Biol Macromol. 2022 Oct 10; S0141-8130(22)02280-2. (SCI, IF=8.025, Top, JCR Q1) Shui Guan*, Yangbin Wang, Feng Xie, Shuping Wang, Weping Xu, Jianqiang Xu*, Changkai Sun*. Carboxymethyl chitosan and gelatin hydrogel scaffolds incorporated with conductive PEDOT nanoparticles for improved neural stem cell proliferation and neuronal differentiation. Molecules, 2022, 27, 8326. (SCI, IF=4.927, JCR Q2) Rui Yang#, Shibo Sun#, Yining Guo, Yao Meng, Haowen Liu, Meiyun Shi, Shui Guan*, Jianqiang Xu*. Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells. Molecules, 2022, 28, 107. (SCI, IF=4.927, JCR Q2) Xie F., Wang S.P., Sun C.K.*, Guan S*. Preparation of conductive hydrogel and its effect on the proliferation of neural stem cells. 10th Annual International Conference on Material Science and Engineering (ICMSE 2022), Sep 2022. (EI) Li J., Xu C., Sun C.K.*, Guan S*. Edaravone-Loaded Sodium Alginate/Carboxymethyl Chitosan Composite Flim for the Healing of Chronic Wound. 10th Annual International Conference on Material Science and Engineering (ICMSE 2022), Sep 2022. (EI) Chao Xu, Shui Guan*, Jianqiang Xu, Weitao Gong, Tianqing Liu, Xuehu Ma, Changkai Sun. Preparation, Characterization and Antioxidant Activity of Protocatechuic Acid Grafted Carboxymethyl Chitosan and Its Hydrogel. Carbohydrate Polymers, 2021, 252: 117210. (SCI/EI, IF=10.723, Top, JCR Q1) 被引频次:46 Shuping Wang, Shui Guan*, Wenfang Li, Dan Ge, Jianqiang Xu, Changkai Sun, Tianqing Liu, Xuehu Ma. 3D culture of neural stem cells within conductive PEDOT layer-assembled chitosan/gelatin scaffolds for neural tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 2018, 93: 890-901. (SCI/EI, IF=8.457, JCR Q1) 被引频次:65 Chao Xu, Shui Guan*, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Tianqing Liu, Xuehu Ma. Synthesis of protocatechuic acid grafted chitosan copolymer: structure characterization and in vitro neuroprotective potential. International Journal of Biological Macromolecules, 2018, 109: 1-11. (SCI, IF=8.025, Top, JCR Q1) 被引频次:23 Chao Xu, Shui Guan*, Shuping Wang, Weitao Gong, Tianqing Liu, Xuehu Ma, Changkai Sun. Biodegradable and electroconductive poly(3,4-ethylenedioxythiophene)/ carboxymethyl chitosan hydrogels for neural tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 2017, 84: 32-43. (SCI/EI, IF=8.457, JCR Q1) 被引频次:60 Shuping Wang, Shui Guan*, Jianqiang Xu, Wenfang Li, Dan Ge, Changkai Sun, Tianqing Liu, Xuehu Ma. Neural stem cells proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering. Biomaterials Science, 2017, 5: 2024-2034. (SCI/EI, IF=7.59, JCR Q1, Cover) 被引频次:61 Shuping Wang#, Changkai Sun#, Shui Guan*, Wenfang Li, Jianqiang Xu, Dan Ge, Meiling Zhuang, Tianqing Liu, Xuehu Ma. Chitosan/gelatin porous scaffolds assembled with conductive poly (3,4-ethylenedioxythiophene) nanoparticles for neural tissue engineering. Journal of Materials Chemistry B, 2017, 5: 4774-4788. (SCI/EI, IF=7.571, Top, JCR Q1) 被引频次:88 Shuping Wang, Shui Guan*, Jing Wang, Hailong Liu, Tianqing Liu, Xuehu Ma, Zhanfeng Cui. Fabrication and characterization of conductive poly(3,4-ethylenedioxythiophene) doped with hyaluronic acid/poly(L-lactic acid) composite film for biomedical application, Journal of Bioscience and Bioengineering, 2017, 123: 116-125. (SCI/EI, IF=3.185, JCR Q3) 被引频次:41 Shuping Wang, Shui Guan*, Zhibo Zhu, Wenfang Li, Tianqing Liu, Xuehu Ma. Hyaluronic acid doped-poly(3,4-ethylenedioxythiophene)/chitosan/gelatin (PEDOT-HA/Cs/Gel) porous conductive scaffold for nerve regeneration, Materials Science & Engineering C-Materials for Biological Applications, 2017, 71: 308-316. (SCI/EI, IF=8.457, JCR Q1) 被引频次:69 Shui Guan*, Jianqiang Xu, Yifu Guo, Dan Ge, Tianqing Liu, Xuehu Ma, Zhanfeng Cui. Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells. International Journal of Developmental Neuroscience, 2015, 42, 37-45. (SCI, IF=2.54, JCR Q3) 被引频次:11 Shui Guan*, Xiuli Zhang, Xiaomin Lin, et al. Chitosan/gelatin porous scaffolds containing hyaluronic acid and heparan sulfate for neural tissue engineering. Journal of Biomaterials Science, Polymer Edition, 2013, 24(8): 999-1014. (SCI/EI, IF=3.682, JCR Q2) 被引频次:51 Shui Guan*. Development of in Vitro Neural Models for Drug Discovery and Toxicity Screening. In: Murray Moo-Young (Ed.), Comprehensive Biotechnology, 2e, 2011. Publisher: Elsevier, Amsterdam, Netherlands, pp. 565-572. (SCI) Shui Guan*, Xiuli Zhang, Dan Ge, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells. European Journal of Pharmacology, 2011, 670 (2-3): 471-478. (SCI, IF=5.195, JCR Q2) 被引频次:14 Xiu-li Zhang, Gui-Fang Shi, Xiu-zhen Liu, Li-jia An, Shui Guan*. Anti-aging effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice. Cell Biochemistry and Function, 2011, 29 (4): 342-347. (SCI, IF=3.963, JCR Q3) 被引频次:44 Shui Guan*, Dan Ge, Tianqing Liu, Xue-hu Ma, Zhan-fang Cui. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Toxicology in Vitro, 2009, 23(2), 201-208. (SCI, IF=3.685, JCR Q2) 被引频次:72 Shui Guan, Jiang B, Bao YM, An LJ. Protocatechuic acid suppresses MPP+-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food and Chemical Toxicology, 2006, 44 (10): 1659-1666. (SCI, IF=4.679, JCR Q1) 被引频次:57 Shui Guan, Bao YM, Jiang B, An LJ. Protective effect of protocatechuic acid from Alpinia oxyphylla on hydrogen peroxide-induced oxidative PC12 cell death. European Journal of Pharmacology, 2006, 538 (1-3): 73-79. (SCI, IF=5.195, JCR Q2) 被引频次:112 An LJ, Guan S, Shi GF, Bao YM, Duan YL, Jiang B. Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells. Food and Chemical Toxicology, 2006, 44 (3): 436-443. (SCI, IF=5.572, JCR Q1) 被引频次:119

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