王守锋 - 济南大学 - 化学化工学院

研究领域

氟代天然药物的突变生物合成及其化学生物学理化性质导向的含氟化合物的合成理化性质导向的含氟化合物的合成

近期论文

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Insights into quinaldic acid moiety formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation. Lian Duan#; Shoufeng Wang#; Ri Jing Liao; Wen Liu*. Chem.Biol., 2012, 19, 443-448（IF: 6.64）. Opportunities and challenges from current investigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics. Shoufeng Wang; Shuai-xiang Zhou; Wen Liu*. Curr. Opin. Chem. Biol., 2013, 17, 626-634（IF：9.85）. Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis. Qing-Fei Zheng; Shoufeng Wang*; Wen Liu*. Tetrahedron, 2014, 70, 7686-7690（IF：2.64）. Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties. Shoufeng Wang#；Qingfei Zheng#；Jianfeng Wang； Zhixiong Zhao；Qingye Li；Yunsong Yu; Renxiao Wang; Wen Liu*. Org. Chem. Front., 2015, 2, 106–109（IF：4.69）. Thiopeptide antibiotics exhibit a dual mode of action against intracellular pathogens by affecting both host and microbe. Qingfei Zheng#; Qinglan Wang#; Shoufeng Wang#; Jiequn Wu; Qian Gao*; Wen Liu*. Chem. Biol., 2015, 22, 1002-1007（IF: 6.64）. Concurrent modifications of the C-terminus and side ring of thiostrepton and their synergistic effects with respect to improving antibacterial activities. Shoufeng Wang#*; Qingfei Zheng#; Jianfeng Wang; Dandan Chen; Yunsong Yu; Wen Liu*. Org. Chem. Front., 2016, 3, 496-500（IF：4.69）. Precursor-directed mutational biosynthesis facilitates the functional assignment of two cytochromes P450 in thiostrepton biosynthesis. Qingfei Zheng#; Shoufeng Wang#*; Rijing Liao; Wen Liu*. ACS Chem. Biol., 2016, 11, 2673−2678（IF：5.09）. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization. Qingfei Zheng#, Shoufeng Wang#, Panpan Duan, Rijing Liao, Dandan Chen, Wen Liu*. Proc. Natl. Acad. Sci. USA., 2016, 113, 14318-14323（IF：10.28）.