吴金美 - 江苏科技大学 - 生物技术学院

个人简介

教育经历博士后，1996.10～1997.10，美国德克萨斯农工大学高等无脊椎动物分子科学研究中心；博士后，1997.11～1998.10 美国德克萨斯大学西南医学中心博士， 1993.09～1996.06，中国农业科学院研究生院 (家蚕及杆状病毒分子生物学)；硕士， 1985.09～1988.06，浙江农业大学（家蚕生理生化及激素调控机理）；学士， 1980.08～1984.08，浙江农业大学（蚕桑专业）工作经历 1988.08～今中国农业科学院蚕业研究所病理生理研究室及农业部家蚕生物技术重点实验室工作。 2002.12～江苏科技大学生物技术学院 2006.03～2007.08 美国威斯康星医学院医学系高访 2000.06～2002.12 美国密苏里大学哥伦比亚分校高访 1994.09～1996.06 中国科学院上海生物化学研究所研修 1990.03～1990.10 印度国际热带蚕业研究中心交流访问

研究领域

（1）家蚕天然免疫相关基因及信号通路（2）家蚕lncRNA的功能（3）ABC转运子的结构与功能及其与代谢疾病的关系

近期论文

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[1] Yang Jie, Wang Xiaonan, Tang Shunming, Shen Zhongyuan, Wu Jinmei* (2015) Peptidoglycan Recognition Protein S2 From Silkworm Integument: Characterization,Microbe-Induced Expression, and Involvement in the Immune-Deficiency Pathway.Journal of Insect Science15(20) DOI:10.1093/jisesa/iev007. [2]Wu Jinmei*, Patel SB (2016) ATP-binding Cassette Sub-Family G Member 4(ABCG4) Plays an Important Role in Lipid Homeostasis of Mouse Brain. Basic & Clinical Pharmacology & Toxicology Vol.118 S1 p21 [3] Wang Xiaonan, Li Xihai, Yang Jie, Yu Ming, Wu Jinmei* (2016) Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimer's disease. Bangladesh Journal of Pharmacology Vol.11:S92-S97 [4] Liu Ji, Yang Jie, Wang Xiaonan,Zhang Yang,Shen Zhongyuan, Wu Jinmei* (2016) The Bmspatzle5 Gene Encodes a Component of Toll-signaling Pathway Against Fungus and Gram-positive Bacteria Invasion in the Integument of Silkworm, Bombyx Mori. Proceedings of the 2016 International Conference on Biotechnology and Medical Science.p129-138. [5] Xu Ying, Liu Ji, Li Fengpeng, Wang Xuefang,Li Xihai, Shen Zhongyuan,Wu Jinmei* (2015) Immune-Related Gene Spatzle4 and Its Diferential Immune Responses against Microbes in the Silkworm, Bombyx Mori. American Journal of Clinical and Experimental Medicine3(6):344-349. [6] Liu Ji, Wu Jinmei* (2015) Progress of Research on Spatzle and Toll Signaling Pathway in Insects. American Journal of Bioscience and Bioengineering. 3(5):134-141. [7] Li Fengpeng, Wang Xuefang, Xu Ying, Wu Jinmei* (2015) Characterization of ATP-binding Cassette Transporter Genes in Silkworm, Bombyx Mori. American Journal of Bioscience and Bioengineering. 3(5):123-133. [8] Wu Jinmei*, Patel SB (2015) Gender-specific Effect of Deficient Abcg4 on Lipogenesis in a Mouse Brain. Journal of Investigative Medicine 63(8):S68-69. [9] Jinmei Wu* (2011) Interference in the Expression of ATP-binding Cassette Transporter G4 (abcg4) Increased Amyloid Precursor Protein (APP) Level in Mouse Brain. BIT's 2nd Annual World Congress of NeuroTalk – 2011. 2011:p328. [10] Jinmei Wu*, Shailesh B. Patel (2015) Gender-specific Effect of Deficient Abcg4 on Lipogenesis in Mouse Brain. Proceedings of 2015 3rd International Conference on Biomedicine and Pharmaceutics. P399-403. [11] Jinmei Wu, Robert W. Lim (2005) Regulation of Inhibitor of Differentiation gene 3 (Id3) expression by Sp2-motif binding factor in myogenic C2C12 cells: Down regulation of DNA binding activity following skeletal muscle differentiation.Biochimica et Biophysica Acta1731:13 – 22. [12] Robert Wai-sui LIM, Jin-mei WU (2005) Molecular mechanisms regulating expression and function of transcription regulator Inhibitor of Differentiation 3 (Id3) Acta Pharmacologica Sinica Vol.26 Issue 12 Page1409-1420 [13] Jinmei Wu, Shailesh B. Patel (2007) Characterization of a mouse deficient in Abcg4. Research Day, Medical College of Wisconsin Jan 18, 2007. [14] Wu J., Zhu Y. and Patel, SB. (1999) Cyclosporin-induced dyslipo- proteinemia is associated with selective activation of SREBP-2.American Journal of Physiology (Endocrinol. Metab. 40). 277(6): E1087-E1092. [15] Wu J, Lim RW, Wu XF, Lu HS. (2003) Cloning and sequence analysis of iap1 gene of Bombyx mori nuclear polyhedrovirus ZJ strain and its function on regulating NF-kB activity in mammalian cells (full article in English). Acta Sericologica Sinica; 29(4): 359-364. [16] 李锡海,于明,吴金美*(2013) 阿尔茨海默病相关生物标志物的研究现状及进展[J] 江苏大学学报(医学版) 23(1): 84-88. [17] 王雪芳，吴金美*（2013） Abcg4在小鼠组织中的表达及其RNA干涉的研究江苏科技大学学报（自然科学版）27(1):89-92. [18] 栗凤鹏,王雪芳,吴金美*(2011) 家蚕新的卵色相关基因Bmwh2的克隆及组织表达与功能研究[J]蚕业科学. vol.37(No.2):193-199. [19] 栗凤鹏,吴金美*(2011) 家蚕三磷酸腺苷结合盒转运子B亚族基因Abcb6的克隆与序列分析及组织表达[J]蚕业科学.vol.37(04) [20] Jinmei Wu (2010) Increased gonadal fat ratio and cerebral ketone body formation but greatly suppressed brain glycogenesis in the female mice deficient in abcg4. 中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议，2010年8月23-26日南京