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个人简介

1997年获美国北卡罗莱纳大学分子生物学和遗传学博士学位,随后在普林斯顿大学做博士后,1999年起在美国哥伦比亚大学任教授,2008年加入北京大学医学部任淑范讲座教授,2015起年任林松年基金讲座教授。尹玉新教授长期从事肿瘤发生机理的研究,主要关注抑癌基因在细胞周期调控、细胞凋亡和基因组稳定性以及细胞代谢中发挥的作用。发表SCI论文160余篇,重要成果以第一作者/通讯作者发表于 Cell , Nature , Nature Immunology , Cell Metabolism, PNAS , Science Translational Medicine 等国际顶尖杂志。研究团队2017年获“中华医学科技奖”二等奖。

研究领域

1. 抗癌基因PTEN家族在肿瘤和代谢中的作用 2. 肿瘤免疫的机制研究及肿瘤免疫治疗 3. 肿瘤的代谢组学研究及早期诊断 4. 脑认知与记忆的机制研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Yin, Y.*, Liu, Y. X., Jin, Y. J., Hall, E. J., and Barrett, J. C. (2003). PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. Nature 422:527-531. 2. Shen, W. H., Balajee, A. B., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y.* (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157-170. 3. Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M.A., Shen, W.H.,* and Yin, Y.*. (2014). PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function. Cell Metab . 19, 836-848. 4. Lu, D., Liu, L., Ji, X., Gao, Y., Chen, X., Liu, Y., Liu, Y., Zhao, X., Li, Y., Li, Y., Jin, Y., Zhang, Y., McNutt, M.A., Zhang, Y., and Yin, Y.*(2015).The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol., 16, 1263-1273. 5. Lu, D., Liu, L., Sun, Y., Song, J., Yin, Q., Zhang, G., Qi, F., Hu, Z., Yang, Z., Zhou, Z., Hu, Y., Zhang, L., Ji, J., Zhao, X., Jin, Y., McNutt, M. A., Yin, Y*. (2020). The phosphatase pac1 acts as a t cell suppressor and attenuates host antitumor immunity. Nat. Immunol. 21, 287-297 6. Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R., Hou, Y., Li, Y., Pan, S., Huang, Y., Yang, F., Bai, F., Nie, H., Di, S., Guo, L., Meng, Z., Wang, J., Yin, Y*. (2022). Systematic analyses of early-stage lung cancer by scRNA-seq and lipidomic reveal aberrant lipid metabolism as detection biomarkers. Science Translational Medicine 14(630):eabk2756.

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