张晓伟 - 北京大学 - 基础医学院

个人简介

1994-1999，毕业于北京大学医学部生化与分子生物学系，获博士学位 1999-2003，北京大学医学部生化与分子生物学系教授 2003-2006，在美国Tufts University做博士后研究工作 2001-2013，北京大学医学部生化与分子生物学系副教授 2013-至今，北京大学医学部生化与分子生物学系教授

研究领域

一直从事细胞衰老和肿瘤发生的分子机制的研究

近期论文

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1.Wang W, Chen Y, Wang S, Hu N, Cao Z, Wang W, Tong T,Zhang X*. PIASxα enhances SUMO1 modification of PTENas a SUMO E3 ligase. J Biol Chem ., 2014, 289(6):3217-3230. 2.Pan K, Chen Y, Roth M, Wang W, Wang S, Yee AS, Zhang X*. HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Mol Cell Biol., 2013, 33(5):887-903. 3.Wang W, Pan K, Chen Y, Huang C, Zhang X*. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. Nucleic Acids Research, 2012, 40(3):981-995. 4.Li H, Wang W, Liu X, Pauson EK., Yee AS,Zhang X*.Transcriptional factor HBP1 targets P16INK4A, upregulating its expression and consequently is involved in Ras-induced premature senescence. Oncogene , 2010, 29:5083-5094. 5.Zhang X, Kim J, Ruthazer R, Pauson EK., Yee AS. The HBP1 transcriptional repressor participates in Ras-induced premature senescence. Mol Cell Biol., 2006, 26(22):8252-8266. 6.Zhang X, Chen Z, Chen Y, Tong Tan. Delivering antisense telomerase RNA by a hybrid adenovirus/adeno-associated virus significantly suppresses the malignant phenotype and enhances cell apoptosis of human breast cancer cells. Oncogene , 2003, 22: 2405-2416.