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个人简介

高涛,博士,副教授,硕士生导师。于2016年6月获南京大学生物学博士学位,同年8月入选全国“博士后创新人才支持计划”,2019年入选江苏省“双创博士”、南京师范大学“中青年领军人才”,2021年入选江苏省“双创团队”。目前主持国家级和省部级项目5项,发表高质量SCI期刊论文60余篇,撰写Springer、Elsevier专著4章节,发表的论文期刊包括Nat. Commun.、CCS Chem.、Nano Lett.、Anal. Chem.、Biosens. Bioelectron.、Cell Commun. Signal.、ACS Appl. Mater. Interfaces、Sens. Actuator B-Chem.等。 教育与研究经历 2019-07 至 今, 南京师范大学, 生命科学学院, 副教授 2018-09 至 2019-06, 南京师范大学, 生命科学学院, 讲师 2016-09 至 2018-08, 上海大学, 信息与通信工程学院 生物医学工程系 2011-09 至 2016-06, 南京大学, 生物学, 博士 2007-09 至 2011-06, 南通大学, 生物技术, 学士

研究领域

以生命体系中的电活性分子、电子传递链、电活性细胞等作为生物电子元件,探究跨“生物-器件”微纳界面的质荷传输机制和特性,研究生命体系的质荷传输及其反应机理,进行生物活体的信号获取和功能调控研究,为面向生命健康的生物电子元件、生物传感器和医学诊疗器件开发提供理论基础与技术创新。 (1)核酸、蛋白质分子的电化学特性研究; (2)生物电子器件与微纳传感界面的设计与构建; (3)疾病分子靶标的精准筛查及医学检验新方法、新技术

近期论文

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Baoguo Wang, Jin Zhu, Tianxiang Wei*, Yixin Zhang, Mingyue Li, Zilong Zhang, Tao Gao*, Zhihui Dai*, Interactional analysis of single mitochondrial function directly in living cell reveals the proton circuit decoupling of mitochondria at the preliminary stage of apoptosis, CCS Chem., 2024, DOI: 10.31635/ccschem.024.202404066. Guo, J.; Li, M.; Long, S.; Zhu, J.; Miao, P.; Wei, T.; Gao, T.*, Bio-inspired electrochemical detection of nitric oxide promoted by coordinating the histamine-iron phthalocyanine catalytic center on microelectrode. Anal. Chem. 2023, 95 (23), 8842-8849. Zhu, J.; Wang, B.; Zhang, Y.; Wei, T.; Gao, T.*, Living electrochemical biosensing: Engineered electroactive bacteria for biosensor development and the emerging trends. Biosens. Bioelectron. 2023, 237, 115480. Wang, X.; Gao, T.*; Zhu, J.; Long, S.; Zhao, S.; Yuan, L.*; Wang, Z.*, Fabrication of channeled and three-dimensional electrodes for the integrated capture and detection of invasive circulating tumor cells during hematogenous metastasis. Anal. Chem. 2023, 95 (4), 2496-2503. Zhang, Y.; Xu, Q.; Wang, F.; Gao, T.*; Wei, T.*, Enzyme powered self-assembly of hydrogel biosensor for colorimetric detection of metabolites. Sens. Actuator B-Chem. 2023, 375, 132942. Wang, X.; Zhao, S.; Wang, Z.; Gao, T.*, Platelets involved tumor cell EMT during circulation: Communications and interventions. Cell Commun. Signal. 2022, 20 (1), 82. Guo, J.; Wei, T.; Huang, Q.; Li, M.; Yang, C.; Mou, J.; Shi, L.; Gao, T.*; Li, G. X.*, Direct acupuncture of nitric oxide by an electrochemical microsensor with high time-space resolution. Biosens. Bioelectron. 2022, 195, 113667. Shi, L.; Kuang, D.; Ma, X.; Jalalah, M.; Alsareii, S. A.; Gao, T.*; Harraz, F. A.*; Yang, J.; Li, G. X.*, Peptide assembled in a nano-confined space as a molecular rectifier for the availability of ionic current modulation. Nano Lett. 2022, 22 (3), 1083-1090. Wang, L.; Li, H.; Shi, L.; Li, L.; Jia, F.; Gao, T.*; Li, G. X.*, In situ peptide self-assembly on ionic nanochannel for dynamic monitoring of MMPs in extracellular matrix. Biosens. Bioelectron. 2022, 195, 113671. Gao, T.*; Zhao, S.; Sun, J.; Huang, Q.; Long, S.; Lv, M.; Ma, J.; Guo, Z. G.*; Li, G. X.*, Single-cell quantitative phenotyping via the aptamer-mounted nest-PCR (apt-nPCR). Anal. Chem. 2022, 94 (5), 2383-2390. Zeng, Y.; Gao, T.*; Li, G. X.*, Molecular modification and assembly at cell surface for biochemical analysis. SCIENTIA SINICA Vitae 2021, 52 (3), 373-386. Shi, L.; Wang, L.; Ma, X.; Jalalah, M.; Alsareii, S. A.; Gao, T.*; Harraz, F. A.*; Li, G. X.*, Electrochemical trans-channel assay for efficient evaluation of tumor cell invasiveness. ACS Appl. Mater. Interfaces 2021, 13 (15), 17268-17275. Jiao, J.; Duan, C.; Zheng, J.; Li, D.; Li, C.; Wang, Z.; Gao, T.*; Xiang, Y.*, Development of a two-in-one integrated assay for the analysis of circRNA-microRNA interactions. Biosens. Bioelectron. 2021, 178, 113032. Shi, L.; Jia, F. J.; Wang, L.; Jalalah, M.; Al-Assiri, M.; Gao, T.*; Harraz, F. A.*; Li, G. X.*, Fabrication of an artificial ionic gate inspired by mercury-resistant bacteria for simple and sensitive detection of mercury ion. Sens. Actuator B-Chem. 2021, 326. Yang, Y.; He, M.; Wei, T.; Sun, J.; Wu, S.; Gao, T.*; Guo, Z.*, Photo-affinity pulling down of low-affinity binding proteins mediated by post-translational modifications. Anal. Chim. Acta 2020, 1107, 164-171. Shi, L.; Mu, C.; Gao, T.; Chai, W.; Sheng, A.; Chen, T.; Yang, J.; Zhu, X.; Li, G. X., Rhodopsin-Like Ionic Gate Fabricated with Graphene Oxide and Isomeric DNA Switch for Efficient Photocontrol of Ion Transport. J. Am. Chem. Soc. 2019, 141 (20), 8239-8243. Gao, T.; Chen, T.; Feng, C.; He, X.; Mu, C.; Anzai, J. I.; Li, G. X., Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells. Nat. Commun. 2019, 10 (1), 2946. Gao, T.; Li, L.; Chen, T.; Shi, L.; Yang, Y.; Li, G. X., DNA-Oriented Shaping of Cell Features for the Detection of Rare Disseminated Tumor Cells. Anal. Chem. 2019, 91 (1), 1126-1132. Gao, T.; Zhi, J.; Mu, C.; Gu, S.; Xiao, J.; Yang, J.; Wang, Z.; Xiang, Y., One-step detection for two serological biomarker species to improve the diagnostic accuracy of hepatocellular carcinoma. Talanta 2018, 178, 89-93. Gao, T.; Mu, C.; Shi, H.; Shi, L.; Mao, X.; Li, G. X., Embedding Capture-Magneto-Catalytic Activity into a Nanocatalyst for the Determination of Lipid Kinase. ACS Appl. Mater. Interfaces 2018, 10 (1), 59-65. Gao, T.; Wang, B.; Shi, L.; Zhu, X.; Xiang, Y.; Anzai, J. I.; Li, G. X., Ultrasensitive Quantitation of Plasma Membrane Proteins via isRTA. Anal. Chem. 2017, 89 (20), 10776-10782. Gao, T.; Li, L. D.; Wang, B.; Zhi, J.; Xiang, Y.; Li, G. X., Dynamic electrochemical control of cell capture-and-release based on redox-controlled host-guest interactions. Anal. Chem. 2016, 88 (20), 9996-10001. Gao, T.; Liu, F. Z.; Yang, D. W.; Yu, Y.; Wang, Z. X.; Li, G. X., Assembly of selective biomimetic surface on an electrode surface: A design of nano-bio interface for biosensing. Anal. Chem. 2015, 87 (11), 5683-5689.

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