李文广 - 兰州大学 - 甘肃省新药临床前研究重点实验室

个人简介

教育背景： 1983年9月至1988年7月在原兰州医学院临床医学系攻读本科 1988年9月至1991年7月在原兰州医学院药理学攻读硕士 2003年9月至2006年6月在兰大生命科学学院攻读博士工作经历： 1991年7月至1994年7月兰州医学院药理学教研室助教 1994年7月至1998年7月兰州医学院药理学教研室讲师 1998年7月至2003年12月兰州医学院药理学教研室副教授 2003年12月至2004年11月兰州医学院药理学教研室教授 2004年11月至今兰州大学药学院药理学教研室教授

研究领域

抗肿瘤药理学。新药临床前药理学。

近期论文

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LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI) 。 LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727?732. (SCI) WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941?949. (SCI) Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179-188. (SCI) WU Yong-jie, LI Wen-guang, ZHANG Zhen-ming and TIAN Xuan. Antioxidative activity of 4-oxy and 4-hydroxy nitroxides in tissues and erythrocytes from rats. cta Pharmacologica Sinica. 1997; 18(6):510-514 XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247?1257. (SCI) XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309?318. (SCI) XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043?1052. (SCI) XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432?438. (SCI) TIAN Xuan, ZHANG Fu-min and LI Wen-guang. Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congener. Life Sciences. 2002; 70:2433-2443 WANG Jun-zhi, BAI De-cheng, RAO Chun-ming, LI Wen-guang, GAO Ming-tang, WANG Xiao-qi and WU Yong-jie. Effects of 2.5s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats. Acta Pharmacologica Sinica. 1997; 18(6):501-504 ZHANG Yi, WANG Jun-zhi, WU Yong-jie and LI Wen-guang. Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism. Acta Pharmacologica Sinica. 2002; 23(5):439-444 XUE Xiao-chang, WU Yong-jie, GAO Ming-tang, LI Wen-guang, ZHAO Ning, WANG Zen-glu, BAO Chun-jie, YAN Zhen and ZHANG Ying-qi. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J. Gastroenterol. 2004; 10(7):1032-1036 Xiaoyu ZHANG, Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533?538. (SCI) WANG Jun-zhi, WU Yong-jie, RAO Chun-ming, GAO Ming-tang and LI Wen-guang. Effect of recombinant human basic fibroblast growth factor on stomach ulcers in rats and mice. Acta Pharmacologica Sinica. 1999; 20(8):763-768 ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI　Wei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386. (CSCD) ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16.(CSCD) ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extract in vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120. ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J. Lanzhou University ( Natural Sci). 2004; 40Supp: 34?36. .(CSCD) ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17. .(CSCD) LI WenGuang, ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424. .(CSCD)