个人简介
上海交通大学副研究员，博士生导师，从事微生物细胞工厂的构建，实现蘑菇真菌源重要代谢物的高效生物合成。基于合成生物学、基因组编辑等策略，挖掘决定细胞工厂优良性状的关键遗传因子并解析其机制。
2012年，获得中国科学院上海生命科学研究院微生物学博士学位；
2012-2015年，在美国伊利诺伊大学厄巴那香槟分校从事博士后研究；
2015-今，上海交通大学，副研究员；
2019-今，上海交通大学，博士生导师；
现任上海市生物工程学会合成生物学专业委员会委员、中国医药生物技术协会合成生物技术分会委员。
2017年，荣获上海交通大学晨星优秀青年学者副教授支持计划（B类）
2019年，荣获日本生物技术学会授予的DaSilva Award
2019、2020年，荣获上海交通大学优秀班主任
2023年，荣获镁伽科技授予的镁伽工程奖
2024年，荣获上海市生物工程学会“曼森”生物工程优秀青年科学家奖
研究领域
Mushroom Synthetic Biology
Efficient Biomanufacturing
Develop genome engineering tools and smart response systems in mushroom for applicatons in efficient biosynthesis of secondary metabolites.
Develop and apply genome engineering tools to discover the genetic determinants for chassis cell construction regarding efficient biomanufacturing.
近期论文
查看导师新发文章
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1. Qin Wang, Ye Li, Shunhan Zhang, Wei Yuan, Zeqian Du, Ting Shi, Zhao Chang, Xingye Zhai, Yinhua Lu, Meng Wang, Juan Guo, Jian-Jiang Zhong and Han Xiao* (2025). Decoding and reprogramming of the biosynthetic networks of mushroom derived bioactive type II ganoderic acids in yeast. Cell Discov, 11(1): 61.
2. Qin Wang, Zeqian Du, Zhenhao Li, Wei Yuan, Jian-Jiang Zhong, Juan Guo, Shenggan Luo, Ting Shi* and Han Xiao* (2025). A branchpoint cytochrome P450 CYP512A13 interconverts different types of Ganoderma triterpenoids. ACS Catal, 15, 13428–13443.
3. Yuhuan Luo, Jian-Jiang Zhong* and Han Xiao* (2025). Mechanism and engineering of endoplasmic reticulum-localized membrane protein folding in Saccharomyces cerevisiae. Metab Eng, 90: 43-56.
4. Yuhuan Luo, Zeqian Du, Chenjian Jiang, Ziqian Yu, Jian-Jiang Zhong*, Ting Shi* and Han Xiao* (2023). Rational engineering of a membrane-anchored promiscuous cytochrome P450 for efficient biosynthesis of valuable ganoderic acids. ACS Catal, 13: 15673-15681.
5. Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang, Meng Wang* and Han Xiao* (2022). Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast. Nat Commun, 13: 7740.
6. Yubo Fang and Han Xiao* (2022). The aspartic protease Yps3p and cell wall glucanase Scw10p are novel determinants that enhance the secretion of the anti-tumor triterpenoid GA-HLDOA in Saccharomyces cerevisiae. ACS Synth Biol, 11(9):2917-2926.
7. Pingan Wang, Han Xiao* and Jian-Jiang Zhong* (2020). CRISPR-Cas9 assisted functional gene editing in the mushroom Ganoderma lucidum. Appl Microbiol Biotechnol, 104: 1661-1671.
8. Han Xiao*, Yue Zhang and Meng Wang* (2019). Discovery and engineering of cytochrome P450s for terpenoid biosynthesis. Trends Biotechnol, 37(6): 618-631.
9. Wen-Fang Wang, Han Xiao* (co-first author) and Jian-Jiang Zhong* (2018). Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum. Biotechnol Bioeng, 115(7): 1842-1854.
10. Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan, Ran Chao, Jing Liang and Huimin Zhao* (2018). Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision. Nature Biotechnol, 36(6): 505-508.
学术兼职
上海市生物工程学会合成生物学专业委员会委员
中国医药生物技术协会合成生物技术分会委员
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