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个人简介

1982年 获浙江医科大学医学学士学位 1988年 获浙江医科大学医学硕士学位 1998年 获香港大学博士学位 1998-2005,美国辛辛那提大学,加拿大卡尔加里大学博士后 2005-2008,加拿大卡尔加里大学Assistant Professor 2009年至今 浙江大学教授,博士生导师

研究领域

胚胎着床机制;生殖能力保存;生殖相关性疾病(妊娠糖尿病,妊娠高血压,生殖系统肿瘤)发病机制;胚胎源性成人疾病发生机制。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Tan YJ, Xiong Y, Ding GL, Zhang D, Meng Y, Huang HF*, Sheng JZ*. Cryoprotectants upregulate the expression of mouse 2 oocyte AQP7 that facilitates water diffusion during cryopreservation. Fertility & Sterility 2012 accepted (IF:3.775) 2. Liu XM, Ding GL, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ*, Huang HF*. Down-Regulation of S100A11, a Calcium-Binding Protein, in Human Endometrium May Cause Reproductive Failure. J Clin Endocrinol Metab. 2012 2012 Oct;97(10):3672-83. (IF:5.967) 3. Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PCK, Sheng JZ*, Huang HF*: Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia, Diabetes. 2012 May;61(5):1133-42. (IF:8.286) 4. Zhang D, Tan YJ, Qu F, Sheng JZ, Huang HF. Functions of water channels in male and female reproductive systems. Mol Aspects Med. 2012 Oct;33(5-6):676-90. (IF:9.970) 5. Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ*, Huang HF*. Functional expression of large-conductance calcium-activated potassium channels in human endometrium: a novel mechanism involved in endometrial receptivity and embryo implantation. J Clin Endocrinol Metab. 2012 Feb;97(2):543-53. (IF=5.967) 6. Qu F, Wang FF, Yin R, Ding GL, El-Prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Peter CK Leung, Sheng JZ, Huang HF*: A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells. J Mol Med (Berl) 2012 Aug; 90(8):911-23.(IF:4.668 ) 7. Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF: Small-conductance calcium-activated K+ channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Hum Reprod 2012, 27:1421-1430(IF:4.475 ) 8. Zhou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, Liu AX, Wang TT, Leung PCK, Sheng JZ*, Huang HF*. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab.2011 Sep;96(9):E1399-408.(IF=5.967) 9. Raqeeb A, Sheng JZ,Ao N, Braun A. Purinergic P2Y2 Receptors Mediate Rapid Ca2+ Mobilization, Membrane Hyperpolarization and Nitric Oxide Production in Human Vascular Endothelial Cells. Cell Calcium 2011 Apr;49(4):240-8. (SCI收录,IF=4.288). 10. Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PCK, Huang HF. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab.2011 Mar;96(3):E493-7. (IF=5.967) 11. Wang TT, Wu YT, Dong MY, Sheng JZ, Leung PCK, Huang HF. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. Fertil Steril. 2010 Nov;94(6):2490-2.(IF=3.970) 12. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod. 2010, 25(6):1441-450.(IF=3.859) 13. Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ. Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation. J Biol Chem. 2010 Jan 1;285(1):131-41.(IF=5.520) 14. Sheng JZ, Ella S, Hill M, Davis M, Braun A. Openers of KCa and IKCa Channels Enhance Agonist-evoked Endothelial Nitric Oxide Synthesis and Arteriolar Vasodilation. FASEB J. 2009 Apr;23(4):1138-45 (IF=7.049)

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