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个人简介

教育和科研背景 2002.09-2006.07,中国科学技术大学,生物科学,学士 2006.08-2007.08,中国科学技术大学生命学院,研究助理 2007.09-2012.07,中国科学技术大学,细胞生物学,博士 2012.08-2017.10,美国斯托瓦斯医学研究所,博士后(导师:Linheng Li教授) 2017.11-至今,浙江大学医学院,博士生导师

研究领域

1. 印记基因及其3D空间网络调控造血干细胞稳态的机理; 2. DNA甲基化和差异甲基化区域在白血病发生中的机理; 3. 非编码RNA与造血干细胞稳态; 4. 纳米材料对造血干细胞稳态和肿瘤干细胞的作用和机制。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell. 2016 Feb 4;18(2):214-28. (封面文章). 2. Zhang W*,Qian P*, Zhang X, Zhang M, Wang H, Wu M, Kong X, Tan S, Ding K, Perry JK, Wu Z, Cao Y, Lobie PE, Zhu T. Autocrine/paracrine human growth hormone stimulated miRNA 96-182-183 clusters promotes epithelial-mesenchymal transition and invasion in breast cancer. J Biol Chem. 2015 May 29;290(22):13812-29. 3. Liu Y*, Chen C*, Qian P*, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T, Zhao Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat Commun. 2015 Jan 23;6:5988. 4. Banerjee A*, Qian P*, Wu ZS, Ren X, Steiner M, Bougen NM, Liu S, Liu DX, Zhu T, Lobie PE. Artemin stimulates radio- and chemo-resistance by promoting TWIST1-BCL-2-dependent cancer stem cell-like behavior in mammary carcinoma cells. J Biol Chem. 2012 Dec 14;287(51):42502-15. 5. Qian P, Banerjee A, Wu ZS, Zhang X, Wang H, Pandey V, Zhang WJ, Lv XF, Tan S, Lobie PE, Zhu T. Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells. Cancer Res. 2012 Nov 15;72(22):6036-50. 6. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y, Wang P, Zhao L, Wang J, Wu Q, Song E, Lobie PE, Yin Z, Zhu T. Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 2011 Oct 15;71(20):6463-74. 7. Pandey V*, Qian PX*, Kang J, Perry JK, Mitchell MD, Yin Z, Wu ZS, Liu DX, Zhu T, Lobie PE. Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells. Endocrinology. 2010 Mar;151(3):909-20.

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