个人简介
1998 - 2002,四川大学,生命科学学院,学士
2002 - 2007,北京大学,生命科学学院,博士
工作经历:
2007 - 2009,美国耶鲁大学,医学院,博士后
2009 - 2010,美国M.D.安德森癌症医学中心,博士后
2010 - 2015,浙江大学,生命科学研究院,副教授
2015 - 今 ,浙江大学,医学院基础医学系,博士生导师
近期论文
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1. Liu, T., Ghosal, G., Yuan, J., Chen, J., and Huang, J. (2010). FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329, 693-696.
2. Wan, L.*, Han, J.*, Liu, T.*, Dong, S., and Huang, J. (2013). SPIDR connects the BLM-TopoIIIalpha-RMI1/2 complex with homologous recombination repair. PNAS 110, 10646-10651(* are co-first authors)
3. Liu, T., Wan, L., Wu, Y., Chen, J., and Huang, J. (2011). hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem286, 41758-41766.
4. Liu, T., Chen, H., Kim, H., Huen, M.S., Chen, J., and Huang, J. (2012). RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair 11, 131-138.
5. Liu, T. and Huang, J. (2014). Quality control of homologous recombination. Cell Mol Life Sci. 71 (19): 3779-97 (Corresponding author)
6. Liu,T., Huang,J., and Chen, J. (2010). RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair9, 1241-1248.
7. Liu, T., and Feng, X.H. (2010). Regulation of TGF-beta signalling by protein phosphatases. Biochem J 430, 191-198.
8. Wan, T.*, Liu, T.*, Zhang, H., Tang, S., and Min, W. (2010). AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. J Biol Chem 285, 3750-3757.(* are co-first authors)
9. Huang, J.*, Liu, T.*, Xu, L.G., Chen, D., and Zhai, Z., and Shu, H.B. (2005). SIKE is an IKKepsilon/TBK1-associated suppressor of TLR-and virus-triggered IRF-3 activation pathways. EMBO J 24, 4018-4028.(* are co-first authors)
1. Dong, S., Han, J., Chen, H., Liu, T., Huen, MS., Yang, Y., Guo, C., Huang, J. (2014). The human SRCAP chromatin remodeling complex promotes DNA-End resection. Current Biology. 24(18):2097-2110.
2. Han, J., Liu, T., Huen, MS., Hu, L., Chen, Z., Huang, J. (2014). SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol. 205(6), 811-27.
3. Feng, Y., Wu, H., Xu, Y., Zhang, Z., Liu, T., Lin, X., and Feng, X.H. (2014) Zinc finger protein 451 is a novel Smad corepressor in transforming growth signaling. J Biol Chem 289(4):2072-83.
4. Wan, L., Lou, J., Xia, Y.,bfactor- Su, B., Liu, T., Cui, J., Sun, Y., Lou, H., and Huang, J. (2013). hPrimpol1/CCDC111 is a human DNA primase- polymerase required for the maintenance of genome integrity. EMBO Report 14, 1104-1112.