个人简介
浙江大学医学院病原生物学系副教授,病原生物学博士后,病毒分子生物学方向博士,浙江大学求是青年学者,浙江省微生物学会理事兼副秘书长。主要研究方向为重要人畜共患病病原微生物致病机制及实验室诊断。擅长分子生物学、细胞生物学和免疫学相关实验技术。先后主持国家自然科学基金项目2项,国家博士后基金项目和浙江省自然科学基金项目各1项,参与973项目和国家自然科学基金项目多项;迄今发表研究论文20余篇,其中SCI收录15篇;申请国家发明专利4项,3项已授权。
近期论文
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1. Wang H, Wu Y, Ojcius DM, Yang XF, Zhang C, Ding S, Lin X (corresponding author), Yan J. Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-κB Signaling Pathways. PLoS One. 2012 Aug, 7(8): e42266.(4.092)
2. Lin X, Sun A, Ruan P, Zhang Z, Yan J. Characterization of Conserved T- and B-Cell Combined Epitopes in Leptospira interrogans Major Outer Membrane Protein OmpL1 and LipL41. BMC Microbiol. 2011 Jan, 11, 21. (2.96,3)
3. S Quan, J Wang, X Xia, X Lin, J Yan. Protective effect of puerarin form the roots of Pueraria lobata against systemic inflammatory response syndrome by regulating the levels of related cytokines. J Med Plants Res. 2011 July, 5(13): 2917-2921. (0.59)
4. Lin X, Zhao J, Qian J, Mao Y, Pan J, Li L, Peng H, Luo Y, Yan J. Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoprotein LipL32 and LipL21 of Leptospira interrogans. Clin Vaccine Immunol. 2010 May, 17(5): 778-783.(2.471,2)
5. Lin X, Chen Y, Yi Y, Zhang Z. Baculovirus immediately early 1, a mediator for homologous regions enhancer function in trans. Virol J. 2010 Feb, 7(1): 32.(2.546,2)
6. Lin X, Chen Y, Lu Y, Yan J, Yan J. Application of loop-mediated isothermal amplification method for the detection of pathogenic leptospira. Diagn Micr Infec Dis. 2009 Mar, 63: 237-242.(2.451,13)
7. Lin X, Chen Y, Yan J. Recombinant multiepitope protein for diagnosis of leptospirosis. Clin Vaccine Immunol. 2008 Nov, 15(11): 1711-1714.(2.471,4)
8. Lin X, Chen Y, Yi Y, Yan J, Zhang Z. Promoter analysis of Bombyx mori nucleopolyhedrovirus ubiquitin gene. J Microbiol. 2008 Aug, 46(4): 429-435.(2.05)
9. Lin XA, Chen Y, Xu WH, Yi YZ, Zhang ZF. Characterization of Autographa californica nucleopolyhedrovirus ubiquitin gene promoter. Z Naturforsch [C]. 2008 Mar-Apr, 63c: 277-283.(0.8)
10. Lin X, Zhang W, Chen Y, Yao B, Zhang ZF. Overexpression of celB Gene Coding for β-Glucosidase from Pyrococcus furiosus Using Baculovirus Expression Vector System in Silkworm, Bombyx mori. Z Naturforsch [C]. 2006 Jul-Aug, 61(7-8): 595-600.(0.8)
11. Zhang L, Zhang CL (co-first author), Ojcius M., Zhao JF, Lin XA, Mao YF, Li LW Yan J. The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif-dependent infection of cells and animals. Mol Microbiol. 2012 Feb, 83(5): 1006-1023. (5.01)
12. Chen Y, Lin X, Yi Y, Lu Y, Zhang Z. Construction and application of a baculovirus genomic library. Z Naturforsch [C]. 2009 Jul-Aug, 6 64 c, 574-580 .(0.8)
13. Luo D, Xue F, Ojcius DM, Zhao J, Mao Y, Li L, Lin X, Yan J. Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp. and characterization of their immunogenicity. Vaccine. 2009, 28(1): 243-255. (3.572)
14. Yin Chen, Zhongze Zhu, Xu’ai Lin, Yongzhu Yi, Zhifang Zhang. Overexpression and Characterization of appA Phytase Expressed by Recombinant Baculovirus Infected Silkworm. J Microbiol. Biotechnol. 2005 Jan,15(3): 466-471.(SCI收录)
15. Chen Y, Yao B, Zhu Z, Yi Y, Lin X, Zhang Z, Shen G. A constitutive super-enhancer: homologous region 3 of Bombyx mori nucleopolyhedrovirus. Biochem Biophys Res Commun. 2004 Jun, 318(4): 1039-1044. (SCI收录)