个人简介
戴海斌,男,博士,教授,主任药师,浙江大学博士研究生导师。
目前任浙江大学医学院附属第二医院药学部副主任。主要从事神经药理以及脑血管病的发病机制和防治研究,以及临床药学等工作。曾受国家留学基金委员会资助在美国哈佛大学作访问学者工作一年。目前已发表SCI论文40篇,其中第一/通讯作者文章30篇。曾获省自然科学奖、省科技进步一等奖各一次。担任J Neurochem, Transl Stroke Res, Molecular Neurobiology,等杂志的审稿专家。2、大学开始受教育经历 1993.9~1998.6,中国药科大学,药理学系,学士学位。 2003.9~2008.6,浙江大学医学院,药理学系,博士学位。 3、研究工作经历 1998.8~ 浙江大学医学院附属第二医院,从事脑损伤与修复的分子药理学研究。
近期论文
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(1) Li W, Chen Z, Yuan J, Yu Z, Cheng C, Zhao Q, Huang L, Hajjar KA, Chen Z, Lo EH, Dai H*, Wang X*. Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability. J Cereb Blood Flow Metab. 2018 May 22:271678X18777916. (IF: 6.08)
(2) Li W, Chen Z, Chin I, Chen Z, Dai H*. The role of VE-cadherin in blood-brain barrier integrity under central nervous system pathological conditions. Curr Neuropharmacol. 2018;16(9):1375-1384. (IF: 3.57)
(3) Yu L, Lu Z, Burchell S, Nowrangi D, Manaenko A, Li X, Xu Y, Xu N, Tang J, Dai H*, Zhang JH*. Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice. J Neurochem. 2017 Dec;143(6):750-760 (4.66),*共同通讯作者
(4) Xu H, Ping Y, Lin H, He P, Li W, Dai H*. Antiplatelet Strategies and Outcomes in Patients with Noncardioembolic Ischemic Stroke from a Real-World Study with a Five-Year Follow-Up. Transl Stroke Res. 2017 Jun;8(3):228-233. (8.27)
(5) Xu H, Cai S, Dai H*. Characteristics of Infective Endocarditis in a Tertiary Hospital in East China. PLoS One. 2016 Nov 18;11(11):e0166764. (3.057)
(6) Li W, Chen Z, Yan M, He P, Chen Z, Dai H*. The protective role of Isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen glucose deprivation. J Neurochem. 2016 Feb;136(3):651-9. (4.281)
(7) Fang L, Li X, Zhong Y, Yu J, Yu L, Dai H*, Yan M*. Autophagy protects Human Brain Microvascular Endothelial Cells against Methylglyoxal-induced Injuries: in parallel with Cerebral Ischemic Model in Diabetic Rats. J Neurochem. 2015 135(2):431-40. (4.281)共同通讯作者
(8) Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, Zheng Y, Deng T, Yan H, Li W, Hou WW, Lu J, Shen Y, Dai H, Hu WW, Zhang Z, Chen Z. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. (11.753)
(9) Hu Y, Li L, Li W, Xu H, He P, Yan X, Dai H*. Combination antibiotic therapy versus monotherapy for Pseudomonas aeruginosa bacteraemia: A meta-analysis of retrospective and prospective studies. Int J Antimicrob Agents. 2013.42: 492–496. (4.415)
(10) Li W, Xu H, Hu Y, He P, Ni Z, Xu H, Zhang Z, Dai H*. Edaravone Protected Human Brain Microvascular Endothelial Cells from Methylglyoxal-Induced Injury by Inhibiting AGEs/RAGE/Oxidative Stress. PLoS ONE. 2013. 8(9): e76025. (3.73)
(11) Dai H*, Yu Z, Fan X, Liu N, Yan M, Chen Z, Lo EH, Hajjar KA, Wang X*. Dysfunction of annexin A2 contributes to hyperglycemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb Haemost. 2013 Mar 21;109(6): 1070-8. (6.094)
(12) Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 ;43(2):567-70.(IF:5.756)
(13) Yan M, Dai H, Ding T, Dai A, Zhang F, Yu L, Chen G, Chen Z. Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochem Int. 2011; 58(5):549-57.(IF:3.541),共同第一作者
(14) Fan YY, Hu WW, Dai HB, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cereb Blood Flow Metab. 2011;31(1):305-14. (IF:5.457),共同第一作者
(15) Dai H, Zhang Z, Zhu Y, Shen Y, Hu W, Huang Y, Luo J, Timmerman H, Leurs R, Chen Z. Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H2 receptor/cyclic AMP/protein kinase A and H3 receptor/GABA release pathways. J Neurochem 2006;96:1390-400. (IF:4.260)
(16) Shen Y, Hu WW, Fan YY, Dai HB, Fu QL, Wei EQ, Luo JH, Chen Z. Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors. Biochem Pharmacol 2007;73:709-17. (IF:4.254)